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• W2116748469 abstract "No AccessJournal of UrologyInvestigative Urology1 Mar 2015Galectin-1 Dysregulation Independently Predicts Disease Specific Survival in Bladder Urothelial Carcinoma Ting-Feng Wu, Chien-Feng Li, Lan-Hsiang Chien, Kun-Hung Shen, Hsuan-Ying Huang, Chia-Cheng Su, and Alex C. Liao Ting-Feng WuTing-Feng Wu Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan, Republic of China More articles by this author , Chien-Feng LiChien-Feng Li Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan, Republic of China Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan, Republic of China National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan, Republic of China More articles by this author , Lan-Hsiang ChienLan-Hsiang Chien Department of Urology, Chi-Mei Medical Center, Tainan, Taiwan, Republic of China Current address: Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan, Republic of China. More articles by this author , Kun-Hung ShenKun-Hung Shen Department of Urology, Chi-Mei Medical Center, Tainan, Taiwan, Republic of China Department of Optometry, Chung Hwa University of Medical Technology, Tainan, Taiwan, Republic of China Department of Urology, Taipei Medical University, Taipei, Taiwan, Republic of China More articles by this author , Hsuan-Ying HuangHsuan-Ying Huang Department of Pathology, Chang Gung Memorial Hospital-Kaohsiung Medical Center Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China More articles by this author , Chia-Cheng SuChia-Cheng Su Department of Urology, Chi-Mei Medical Center, Tainan, Taiwan, Republic of China More articles by this author , and Alex C. LiaoAlex C. Liao Department of Urology, Chi-Mei Medical Center, Tainan, Taiwan, Republic of China Department of Senior Citizen Service Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, Republic of China More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.09.107AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Galectin-1 is highly expressed in various tumors and participates in various oncogenic processes. Our previous proteomics investigation demonstrated that galectin-1 is up-regulated in high compared to nonhigh grade lesions. Thus, in the current cohort study we clarified the correlation of galectin-1 over expression with various clinicopathological features and prognosis. Materials and Methods: We selected 185 cases of consecutively treated primary localized bladder urothelial carcinoma for study. Transurethral resection of bladder tumor was performed in all patients followed by radical cystectomy in those with T2 to T4 tumors. Pathological slides were examined to determine cytoplasmic galectin-1 immuno-expression and correlate galectin-1 dysregulation with various clinicopathological factors and disease specific survival. Results: Positive galectin-1 immuno-expression in tumors was significantly linked to pT status (p = 0.0295), histological grade (p = 0.037), vascular invasion (p = 0.0287) and nodal status (p = 0.0012). Galectin-1 over expression in tumors significantly predicted disease specific survival at the univariate (p = 0.0002) and multivariate levels (p = 0.03, HR 2.438, 95% CI 1.090–5.451). In situ hybridization indicated that the LGALS1 gene was amplified in 43 specimens in an independent cohort of 56 snap frozen tumor specimens. Association analysis showed that an increased LGALS1 mRNA level was linked to bladder urothelial carcinoma invasiveness (p = 0.016) and LGALS1 gene amplification was significantly associated the amount of GAL-1 protein in tumors (p <0.0001). On the univariate level gene amplification was also closely linked to disease specific survival (p = 0.0006). Conclusions: These results reveal that galectin-1 over expression is a possible independent factor for bladder cancer prognosis. References 1 : Prognostic markers in bladder cancer: a contemporary review of the literature. J Urol1998; 160: 645. Link, Google Scholar 2 : Urinary markers of bladder carcinoma. Clin Chim Acta2004; 340: 57. Google Scholar 3 : Thermodynamic binding studies of bivalent oligosaccharides to galectin-1, galectin-3 and the carbohydrate recognition domain of galectin-3. Glycobiology2004; 14: 817. Google Scholar 4 : Galectins and cancer. Biochim Biophys Acta2002; 1572: 285. 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Google Scholar 25 : Targeting galectin-1 in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis by downregulating MCP-1/CCL2 expression. Clin Cancer Res2011; 17: 1306. Google Scholar 26 : Galectin-1 and its involvement in hepatocellular carcinoma aggressiveness. Mol Med2010; 16: 102. Google Scholar © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byAndersson K (2018) This Month in Investigative UrologyJournal of Urology, VOL. 193, NO. 3, (751-752), Online publication date: 1-Mar-2015. Volume 193Issue 3March 2015Page: 1002-1008Supplementary Materials Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.Keywordsgalectin 1carcinomaurinary bladderprognosisgene amplificationAcknowledgmentsLaser scanning microdissection was done at the Center for Bioscience and Biotechnology, National Cheng-Kung University, Tainan, Taiwan, Republic of China.MetricsAuthor Information Ting-Feng Wu Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan, Republic of China More articles by this author Chien-Feng Li Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan, Republic of China Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan, Republic of China National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan, Republic of China More articles by this author Lan-Hsiang Chien Department of Urology, Chi-Mei Medical Center, Tainan, Taiwan, Republic of China Current address: Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan, Republic of China. More articles by this author Kun-Hung Shen Department of Urology, Chi-Mei Medical Center, Tainan, Taiwan, Republic of China Department of Optometry, Chung Hwa University of Medical Technology, Tainan, Taiwan, Republic of China Department of Urology, Taipei Medical University, Taipei, Taiwan, Republic of China More articles by this author Hsuan-Ying Huang Department of Pathology, Chang Gung Memorial Hospital-Kaohsiung Medical Center Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China More articles by this author Chia-Cheng Su Department of Urology, Chi-Mei Medical Center, Tainan, Taiwan, Republic of China More articles by this author Alex C. Liao Department of Urology, Chi-Mei Medical Center, Tainan, Taiwan, Republic of China Department of Senior Citizen Service Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, Republic of China More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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