FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116797702> ?p ?o ?g. }

• W2116797702 endingPage "6" @default.
• W2116797702 startingPage "6" @default.
• W2116797702 abstract "Imputation of genotypes for ungenotyped individuals could enable the use of valuable phenotypes created before the genomic era in analyses that require genotypes. The objective of this study was to investigate the accuracy of imputation of non-genotyped individuals using genotype information from relatives. Genotypes were simulated for all individuals in the pedigree of a real (historical) dataset of phenotyped dairy cows and with part of the pedigree genotyped. The software AlphaImpute was used for imputation in its standard settings but also without phasing, i.e. using basic inheritance rules and segregation analysis only. Different scenarios were evaluated i.e.: (1) the real data scenario, (2) addition of genotypes of sires and maternal grandsires of the ungenotyped individuals, and (3) addition of one, two, or four genotyped offspring of the ungenotyped individuals to the reference population. The imputation accuracy using AlphaImpute in its standard settings was lower than without phasing. Including genotypes of sires and maternal grandsires in the reference population improved imputation accuracy, i.e. the correlation of the true genotypes with the imputed genotype dosages, corrected for mean gene content, across all animals increased from 0.47 (real situation) to 0.60. Including one, two and four genotyped offspring increased the accuracy of imputation across all animals from 0.57 (no offspring) to 0.73, 0.82, and 0.92, respectively. At present, the use of basic inheritance rules and segregation analysis appears to be the best imputation method for ungenotyped individuals. Comparison of our empirical animal-specific imputation accuracies to predictions based on selection index theory suggested that not correcting for mean gene content considerably overestimates the true accuracy. Imputation of ungenotyped individuals can help to include valuable phenotypes for genome-wide association studies or for genomic prediction, especially when the ungenotyped individuals have genotyped offspring." @default.
• W2116797702 created "2016-06-24" @default.
• W2116797702 creator A5019401584 @default.
• W2116797702 creator A5027741500 @default.
• W2116797702 creator A5036106191 @default.
• W2116797702 creator A5052146202 @default.
• W2116797702 date "2014-01-01" @default.
• W2116797702 modified "2023-10-16" @default.
• W2116797702 title "Imputation of non-genotyped individuals based on genotyped relatives: assessing the imputation accuracy of a real case scenario in dairy cattle" @default.
• W2116797702 cites W1963543400 @default.
• W2116797702 cites W1992436001 @default.
• W2116797702 cites W2029098072 @default.
• W2116797702 cites W2036326740 @default.
• W2116797702 cites W2039627167 @default.
• W2116797702 cites W2042047883 @default.
• W2116797702 cites W2047977934 @default.
• W2116797702 cites W2054149390 @default.
• W2116797702 cites W2081221567 @default.
• W2116797702 cites W2087036932 @default.
• W2116797702 cites W2090447057 @default.
• W2116797702 cites W2101924605 @default.
• W2116797702 cites W2103589178 @default.
• W2116797702 cites W2104742476 @default.
• W2116797702 cites W2114044285 @default.
• W2116797702 cites W2120216880 @default.
• W2116797702 cites W2122746377 @default.
• W2116797702 cites W2129758928 @default.
• W2116797702 cites W2133289541 @default.
• W2116797702 cites W2139284959 @default.
• W2116797702 cites W2142220815 @default.
• W2116797702 cites W2143768623 @default.
• W2116797702 cites W2149378411 @default.
• W2116797702 cites W2149594592 @default.
• W2116797702 cites W2157211770 @default.
• W2116797702 cites W2160819071 @default.
• W2116797702 cites W2161461762 @default.
• W2116797702 cites W2163566091 @default.
• W2116797702 cites W2164050502 @default.
• W2116797702 cites W2166178841 @default.
• W2116797702 cites W2171937119 @default.
• W2116797702 cites W4240204556 @default.
• W2116797702 doi "https://doi.org/10.1186/1297-9686-46-6" @default.
• W2116797702 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3929150" @default.
• W2116797702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24490796" @default.
• W2116797702 hasPublicationYear "2014" @default.
• W2116797702 type Work @default.
• W2116797702 sameAs 2116797702 @default.
• W2116797702 citedByCount "25" @default.
• W2116797702 countsByYear W21167977022014 @default.
• W2116797702 countsByYear W21167977022015 @default.
• W2116797702 countsByYear W21167977022016 @default.
• W2116797702 countsByYear W21167977022017 @default.
• W2116797702 countsByYear W21167977022018 @default.
• W2116797702 countsByYear W21167977022019 @default.
• W2116797702 countsByYear W21167977022020 @default.
• W2116797702 countsByYear W21167977022021 @default.
• W2116797702 countsByYear W21167977022022 @default.
• W2116797702 countsByYear W21167977022023 @default.
• W2116797702 crossrefType "journal-article" @default.
• W2116797702 hasAuthorship W2116797702A5019401584 @default.
• W2116797702 hasAuthorship W2116797702A5027741500 @default.
• W2116797702 hasAuthorship W2116797702A5036106191 @default.
• W2116797702 hasAuthorship W2116797702A5052146202 @default.
• W2116797702 hasBestOaLocation W21167977021 @default.
• W2116797702 hasConcept C104317684 @default.
• W2116797702 hasConcept C105795698 @default.
• W2116797702 hasConcept C135763542 @default.
• W2116797702 hasConcept C144024400 @default.
• W2116797702 hasConcept C149923435 @default.
• W2116797702 hasConcept C153209595 @default.
• W2116797702 hasConcept C2908647359 @default.
• W2116797702 hasConcept C2992444039 @default.
• W2116797702 hasConcept C33923547 @default.
• W2116797702 hasConcept C54355233 @default.
• W2116797702 hasConcept C58041806 @default.
• W2116797702 hasConcept C86803240 @default.
• W2116797702 hasConcept C9357733 @default.
• W2116797702 hasConceptScore W2116797702C104317684 @default.
• W2116797702 hasConceptScore W2116797702C105795698 @default.
• W2116797702 hasConceptScore W2116797702C135763542 @default.
• W2116797702 hasConceptScore W2116797702C144024400 @default.
• W2116797702 hasConceptScore W2116797702C149923435 @default.
• W2116797702 hasConceptScore W2116797702C153209595 @default.
• W2116797702 hasConceptScore W2116797702C2908647359 @default.
• W2116797702 hasConceptScore W2116797702C2992444039 @default.
• W2116797702 hasConceptScore W2116797702C33923547 @default.
• W2116797702 hasConceptScore W2116797702C54355233 @default.
• W2116797702 hasConceptScore W2116797702C58041806 @default.
• W2116797702 hasConceptScore W2116797702C86803240 @default.
• W2116797702 hasConceptScore W2116797702C9357733 @default.
• W2116797702 hasIssue "1" @default.
• W2116797702 hasLocation W21167977021 @default.
• W2116797702 hasLocation W211679770210 @default.
• W2116797702 hasLocation W21167977022 @default.
• W2116797702 hasLocation W21167977023 @default.
• W2116797702 hasLocation W21167977024 @default.
• W2116797702 hasLocation W21167977025 @default.
• W2116797702 hasLocation W21167977026 @default.

• next