FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116799923> ?p ?o ?g. }

• W2116799923 endingPage "e3391" @default.
• W2116799923 startingPage "e3391" @default.
• W2116799923 abstract "The genetic risk factors predisposing individuals to the development of inflammatory bowel disease are beginning to be deciphered by genome-wide association studies. Surprisingly, these new data point towards a critical role of autophagy in the pathogenesis of Crohn's disease. A single common coding variant in the autophagy protein ATG16L1 predisposes individuals to the development of Crohn's disease: while ATG16L1 encoding threonine at amino acid position 300 (ATG16L1*300T) confers protection, ATG16L1 encoding for alanine instead of threonine (ATG16L1*300A, also known as T300A) mediates risk towards the development of Crohn's disease. Here we report that, in human epithelial cells, the Crohn's disease-associated ATG16L1 coding variant shows impairment in the capture of internalized Salmonella within autophagosomes. Thus, we propose that the association of ATG16L1*300A with increased risk of Crohn's disease is due to impaired bacterial handling and lowered rates of bacterial capture by autophagy." @default.
• W2116799923 created "2016-06-24" @default.
• W2116799923 creator A5019646038 @default.
• W2116799923 creator A5020144264 @default.
• W2116799923 creator A5051945237 @default.
• W2116799923 creator A5056408708 @default.
• W2116799923 creator A5060728613 @default.
• W2116799923 date "2008-10-13" @default.
• W2116799923 modified "2023-10-16" @default.
• W2116799923 title "Impaired Autophagy of an Intracellular Pathogen Induced by a Crohn's Disease Associated ATG16L1 Variant" @default.
• W2116799923 cites W1977767269 @default.
• W2116799923 cites W1988044873 @default.
• W2116799923 cites W1994823455 @default.
• W2116799923 cites W1996068251 @default.
• W2116799923 cites W2001591494 @default.
• W2116799923 cites W2011197968 @default.
• W2116799923 cites W2028057262 @default.
• W2116799923 cites W2039579794 @default.
• W2116799923 cites W2042260827 @default.
• W2116799923 cites W2048705639 @default.
• W2116799923 cites W2074857405 @default.
• W2116799923 cites W2077353205 @default.
• W2116799923 cites W2078621117 @default.
• W2116799923 cites W2084708009 @default.
• W2116799923 cites W2095347614 @default.
• W2116799923 cites W2122031852 @default.
• W2116799923 cites W2149771125 @default.
• W2116799923 cites W2158820172 @default.
• W2116799923 cites W2159792696 @default.
• W2116799923 cites W2165872127 @default.
• W2116799923 doi "https://doi.org/10.1371/journal.pone.0003391" @default.
• W2116799923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2566595" @default.
• W2116799923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18852889" @default.
• W2116799923 hasPublicationYear "2008" @default.
• W2116799923 type Work @default.
• W2116799923 sameAs 2116799923 @default.
• W2116799923 citedByCount "310" @default.
• W2116799923 countsByYear W21167999232012 @default.
• W2116799923 countsByYear W21167999232013 @default.
• W2116799923 countsByYear W21167999232014 @default.
• W2116799923 countsByYear W21167999232015 @default.
• W2116799923 countsByYear W21167999232016 @default.
• W2116799923 countsByYear W21167999232017 @default.
• W2116799923 countsByYear W21167999232018 @default.
• W2116799923 countsByYear W21167999232019 @default.
• W2116799923 countsByYear W21167999232020 @default.
• W2116799923 countsByYear W21167999232021 @default.
• W2116799923 countsByYear W21167999232022 @default.
• W2116799923 countsByYear W21167999232023 @default.
• W2116799923 crossrefType "journal-article" @default.
• W2116799923 hasAuthorship W2116799923A5019646038 @default.
• W2116799923 hasAuthorship W2116799923A5020144264 @default.
• W2116799923 hasAuthorship W2116799923A5051945237 @default.
• W2116799923 hasAuthorship W2116799923A5056408708 @default.
• W2116799923 hasAuthorship W2116799923A5060728613 @default.
• W2116799923 hasBestOaLocation W21167999231 @default.
• W2116799923 hasConcept C126322002 @default.
• W2116799923 hasConcept C187092789 @default.
• W2116799923 hasConcept C190283241 @default.
• W2116799923 hasConcept C203014093 @default.
• W2116799923 hasConcept C203522944 @default.
• W2116799923 hasConcept C2778260677 @default.
• W2116799923 hasConcept C2779134260 @default.
• W2116799923 hasConcept C2779280984 @default.
• W2116799923 hasConcept C54355233 @default.
• W2116799923 hasConcept C71924100 @default.
• W2116799923 hasConcept C7573103 @default.
• W2116799923 hasConcept C86803240 @default.
• W2116799923 hasConceptScore W2116799923C126322002 @default.
• W2116799923 hasConceptScore W2116799923C187092789 @default.
• W2116799923 hasConceptScore W2116799923C190283241 @default.
• W2116799923 hasConceptScore W2116799923C203014093 @default.
• W2116799923 hasConceptScore W2116799923C203522944 @default.
• W2116799923 hasConceptScore W2116799923C2778260677 @default.
• W2116799923 hasConceptScore W2116799923C2779134260 @default.
• W2116799923 hasConceptScore W2116799923C2779280984 @default.
• W2116799923 hasConceptScore W2116799923C54355233 @default.
• W2116799923 hasConceptScore W2116799923C71924100 @default.
• W2116799923 hasConceptScore W2116799923C7573103 @default.
• W2116799923 hasConceptScore W2116799923C86803240 @default.
• W2116799923 hasIssue "10" @default.
• W2116799923 hasLocation W21167999231 @default.
• W2116799923 hasLocation W21167999232 @default.
• W2116799923 hasLocation W21167999233 @default.
• W2116799923 hasLocation W21167999234 @default.
• W2116799923 hasLocation W21167999235 @default.
• W2116799923 hasLocation W21167999236 @default.
• W2116799923 hasLocation W21167999237 @default.
• W2116799923 hasOpenAccess W2116799923 @default.
• W2116799923 hasPrimaryLocation W21167999231 @default.
• W2116799923 hasRelatedWork W1966182769 @default.
• W2116799923 hasRelatedWork W2071025253 @default.
• W2116799923 hasRelatedWork W2071052330 @default.
• W2116799923 hasRelatedWork W2105409495 @default.
• W2116799923 hasRelatedWork W2420744682 @default.
• W2116799923 hasRelatedWork W3030959818 @default.
• W2116799923 hasRelatedWork W3151004848 @default.
• W2116799923 hasRelatedWork W4231022815 @default.

• next