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- W2116882960 endingPage "393" @default.
- W2116882960 startingPage "385" @default.
- W2116882960 abstract "Diabetes and heart failure are very prevalent, and affect each other's incidence and severity. Novel therapies to reduce post-myocardial infarction (MI) remodeling that progresses into heart failure are urgently needed, especially in diabetic patients. Clinical studies have suggested that some oral anti-diabetic agents like metformin exert cardiovascular protective effects in heart failure patients with diabetes, whereas other agents may be deleterious. In the current review, we provide an overview of the cardio-specific effects of oral anti-diabetic drugs in animal models of acute MI, post-MI remodeling, and heart failure. Metformin has consistently been shown to ameliorate cardiac remodeling after ischemia/reperfusion (I/R) injury, as well as in several models of heart failure. Sulfonylurea derivatives are controversial with respect to their direct effects on the cardiovascular system. Thiazolidinediones protect against myocardial I/R injury, but their effects on post-MI remodeling are less clear and clinical studies raised concerns about their cardiovascular safety. Glucagon-like peptide-1 analogs have potential beneficial effects on the cardiovascular system that require further confirmation, whereas the results with dipeptidyl peptidase-4 inhibitors are equivocal. Current clinical guidelines, in the absence of prospective clinical trials that evaluated if certain oral anti-diabetic agents are superior over others, only provide generic recommendations, and do not take into account interesting experimental and mechanistic data. The available experimental evidence indicates that some anti-diabetic agents should be preferred over others if cardioprotective effects are warranted. These experimental clues need to be confirmed by clinical trials." @default.
- W2116882960 created "2016-06-24" @default.
- W2116882960 creator A5003503629 @default.
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- W2116882960 creator A5050307995 @default.
- W2116882960 creator A5059047444 @default.
- W2116882960 creator A5081046720 @default.
- W2116882960 date "2013-11-01" @default.
- W2116882960 modified "2023-10-01" @default.
- W2116882960 title "Variable effects of anti-diabetic drugs in animal models of myocardial ischemia and remodeling: A translational perspective for the cardiologist" @default.
- W2116882960 cites W1889956147 @default.
- W2116882960 cites W1968315455 @default.
- W2116882960 cites W1968785372 @default.
- W2116882960 cites W1972136146 @default.
- W2116882960 cites W1973432709 @default.
- W2116882960 cites W1975057002 @default.
- W2116882960 cites W1980196407 @default.
- W2116882960 cites W1980196565 @default.
- W2116882960 cites W1983128420 @default.
- W2116882960 cites W1983329590 @default.
- W2116882960 cites W1987417961 @default.
- W2116882960 cites W1987941106 @default.
- W2116882960 cites W1988824209 @default.
- W2116882960 cites W1989395929 @default.
- W2116882960 cites W1991096049 @default.
- W2116882960 cites W1994860175 @default.
- W2116882960 cites W1994871458 @default.
- W2116882960 cites W1997416444 @default.
- W2116882960 cites W1997759488 @default.
- W2116882960 cites W1998877815 @default.
- W2116882960 cites W2000976083 @default.
- W2116882960 cites W2003380560 @default.
- W2116882960 cites W2009388700 @default.
- W2116882960 cites W2010927697 @default.
- W2116882960 cites W2014356435 @default.
- W2116882960 cites W2015582203 @default.
- W2116882960 cites W2017505271 @default.
- W2116882960 cites W2019235722 @default.
- W2116882960 cites W2022066415 @default.
- W2116882960 cites W2023097850 @default.
- W2116882960 cites W2029071587 @default.
- W2116882960 cites W2029222229 @default.
- W2116882960 cites W2032509725 @default.
- W2116882960 cites W2034321283 @default.
- W2116882960 cites W2043604223 @default.
- W2116882960 cites W2043619482 @default.
- W2116882960 cites W2046490985 @default.
- W2116882960 cites W2047982128 @default.
- W2116882960 cites W2049355183 @default.
- W2116882960 cites W2049679309 @default.
- W2116882960 cites W2052845991 @default.
- W2116882960 cites W2055100590 @default.
- W2116882960 cites W2055824736 @default.
- W2116882960 cites W2057397568 @default.
- W2116882960 cites W2063400466 @default.
- W2116882960 cites W2065836621 @default.
- W2116882960 cites W2069751465 @default.
- W2116882960 cites W2070647639 @default.
- W2116882960 cites W2072140142 @default.
- W2116882960 cites W2072935519 @default.
- W2116882960 cites W2076439128 @default.
- W2116882960 cites W2077312217 @default.
- W2116882960 cites W2077631321 @default.
- W2116882960 cites W2080121848 @default.
- W2116882960 cites W2085276866 @default.
- W2116882960 cites W2093552577 @default.
- W2116882960 cites W2097668381 @default.
- W2116882960 cites W2102772338 @default.
- W2116882960 cites W2105665055 @default.
- W2116882960 cites W2110103927 @default.
- W2116882960 cites W2110725041 @default.
- W2116882960 cites W2110953198 @default.
- W2116882960 cites W2116407279 @default.
- W2116882960 cites W2126528640 @default.
- W2116882960 cites W2127125241 @default.
- W2116882960 cites W2129601242 @default.
- W2116882960 cites W2131490500 @default.
- W2116882960 cites W2131520853 @default.
- W2116882960 cites W2133752719 @default.
- W2116882960 cites W2134141467 @default.
- W2116882960 cites W2135355659 @default.
- W2116882960 cites W2135378280 @default.
- W2116882960 cites W2135729475 @default.
- W2116882960 cites W2142019270 @default.
- W2116882960 cites W2142039951 @default.
- W2116882960 cites W2144661518 @default.
- W2116882960 cites W2147855451 @default.
- W2116882960 cites W2150180487 @default.
- W2116882960 cites W2150913805 @default.
- W2116882960 cites W2154595662 @default.
- W2116882960 cites W2156029342 @default.
- W2116882960 cites W2156133857 @default.
- W2116882960 cites W2157008873 @default.
- W2116882960 cites W2167522349 @default.
- W2116882960 cites W2169911463 @default.
- W2116882960 cites W2170378756 @default.
- W2116882960 cites W2172279132 @default.
- W2116882960 cites W2188846692 @default.