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• W2117277810 startingPage "1541" @default.
• W2117277810 abstract "Phagocytosis of Clostridium difficile by human polymorphonuclear leukocytes (PMNs) and the possible role of the clostridial toxins in this process were investigated. Phagocytosis of C. difficile was independent of aerobiosis and clearly depended on opsonization. Either complement or antibodies to C. difficile could serve as opsonins. Toxigenic strains of C. difficile were more resistant to phagocytosis than were nontoxigenic strains. Pretreatment of PMNs with as much as 10,000 units of toxins from culture filtrates of C. difficile for 2 h had no effect on either the phagocytic activity of PMNs or their viability as determined by trypan blue exclusion. In contrast, treatment of human embryonic intestinal cells with the same amount of toxin under identical conditions resulted in cell death." @default.
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• W2117277810 date "1987-07-01" @default.
• W2117277810 modified "2023-09-27" @default.
• W2117277810 title "Factors influencing the phagocytosis of Clostridium difficile by human polymorphonuclear leukocytes" @default.
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• W2117277810 doi "https://doi.org/10.1128/iai.55.7.1541-1546.1987" @default.
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