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• W2117333782 abstract "Aim B cells are likely to play critical roles in the pathogenesis of systemic lupus erythematosus (SLE). Our aim was to investigate the role of peripheral CD24hiCD27+CD19+B cells in Chinese patients with new-onset SLE. Method Peripheral CD24hiCD27+CD19+B cells were analyzed in 55 new-onset lupus and 36 healthy controls by flow cytometry. All SLE cases were treated with prednisolone and hydroxychloroquine during a 1-year follow-up. Thirteen cases were added with cyclophosphamide or mycophenolate mofetil. The CD24hiCD27+CD19+B cells were analyzed at days 0, 7, 14 and months 1, 3, 6, 9 and 12. Interleukin-10 (IL-10)-producing B cell was detected in eight naïve lupus and 10 healthy controls. Results Compared to healthy controls, the frequency and number of primary circulating CD24hiCD27+CD19+B cells was significantly reduced in SLE cases (8.22 ± 3.48% vs. 31.67 ± 5.53%, P < 0.0001; 4.04 ± 2.85 vs. 38.66 ± 10.22 103 cells/mL, P = 0.0001) before treatment; IL-10+CD19+B cells and IL-10+CD24hiCD27+CD19+B cells also decreased in SLE. Interestingly, primary CD24hiCD27+CD19+B cells inversely correlated with SLE disease activity index (SLEDAI) score. Patients with arthritis and hematologic disorders had a lower primary CD24hiCD27+CD19+B cells. In 48 SLE cases who finished the 1-year follow-up, the frequency and number of CD24hiCD27+CD19+B cells increased from 8.26 ± 3.61% to 25.51 ± 4.56%; 3.99 ± 2.86 to 28.64 ± 11.81 103cells/mm3 (P < 0.0001), accompanied by a significantly decreased SLEDAI score. Of note, CD24hiCD27+CD19+B cells decreased in some flare cases with an elevated SLEDAI score. Conclusion These results demonstrate that a lower primary CD24hiCD27+CD19+B cells may be an immunologic aspect of new-onset SLE. CD24hiCD27+CD19+B cells may be a useful tool to evaluate lupus activity and monitor the response to therapy." @default.
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• W2117333782 date "2013-11-28" @default.
• W2117333782 modified "2023-10-03" @default.
• W2117333782 title "Peripheral CD24^hiCD27⁺CD19⁺B cells subset as a potential biomarker in naïve systemic lupus erythematosus" @default.
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• W2117333782 doi "https://doi.org/10.1111/1756-185x.12229" @default.
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