FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117681036> ?p ?o ?g. }

• W2117681036 endingPage "2484" @default.
• W2117681036 startingPage "2475" @default.
• W2117681036 abstract "Efavirenz is a potent and selective nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Nucleotide sequence analyses of the protease and RT genes (coding region for amino acids 1 to 229) of multiple cloned HIV-1 genomes from virus found in the plasma of patients in phase II clinical studies of efavirenz combination therapy were undertaken in order to identify the spectrum of mutations in plasma-borne HIV-1 associated with virological treatment failure. A K103N substitution was the HIV-1 RT gene mutation most frequently observed among plasma samples from patients for whom combination therapy including efavirenz failed, occurring in at least 90% of cases of efavirenz-indinavir or efavirenz-zidovudine (ZDV)-lamivudine (3TC) treatment failure. V108I and P225H mutations were observed frequently, predominantly in viral genomes that also contained other nonnucleoside RT inhibitor (NNRTI) resistance mutations. L100I, K101E, K101Q, Y188H, Y188L, G190S, G190A, and G190E mutations were also observed. V106A, Y181C, and Y188C mutations, which have been associated with high levels of resistance to other NNRTIs, were rare in the patient samples in this study, both before and after exposure to efavirenz. The spectrum of mutations observed in cases of virological treatment failure was similar for patients initially dosed with efavirenz at 200, 400, or 600 mg once a day and for patients treated with efavirenz in combination with indinavir, stavudine, or ZDV-3TC. The proportion of patients carrying NNRTI resistance mutations, usually K103N, increased dramatically at the time of initial viral load rebound in cases of treatment failure after exposure to efavirenz. Viruses with multiple, linked NNRTI mutations, especially K103N-V108I and K103N-P225H double mutants, accumulated more slowly following the emergence of K103N mutant viruses." @default.
• W2117681036 created "2016-06-24" @default.
• W2117681036 creator A5003876104 @default.
• W2117681036 creator A5005852106 @default.
• W2117681036 creator A5015708802 @default.
• W2117681036 creator A5033716785 @default.
• W2117681036 creator A5033772097 @default.
• W2117681036 creator A5040842397 @default.
• W2117681036 creator A5043803149 @default.
• W2117681036 creator A5051935108 @default.
• W2117681036 creator A5064778713 @default.
• W2117681036 creator A5076639320 @default.
• W2117681036 creator A5076683227 @default.
• W2117681036 creator A5078612967 @default.
• W2117681036 creator A5078740089 @default.
• W2117681036 creator A5085875099 @default.
• W2117681036 creator A5086208718 @default.
• W2117681036 creator A5088470341 @default.
• W2117681036 date "2000-09-01" @default.
• W2117681036 modified "2023-10-01" @default.
• W2117681036 title "Human Immunodeficiency Virus Type 1 Mutations Selected in Patients Failing Efavirenz Combination Therapy" @default.
• W2117681036 cites W1871915575 @default.
• W2117681036 cites W1964638418 @default.
• W2117681036 cites W1970347994 @default.
• W2117681036 cites W1982575478 @default.
• W2117681036 cites W1989519940 @default.
• W2117681036 cites W1989692384 @default.
• W2117681036 cites W1997844736 @default.
• W2117681036 cites W2024672691 @default.
• W2117681036 cites W2034280823 @default.
• W2117681036 cites W2038636949 @default.
• W2117681036 cites W2045444507 @default.
• W2117681036 cites W2055043387 @default.
• W2117681036 cites W2055705838 @default.
• W2117681036 cites W2067987028 @default.
• W2117681036 cites W2110534111 @default.
• W2117681036 cites W2114671452 @default.
• W2117681036 cites W2118732329 @default.
• W2117681036 cites W2123101436 @default.
• W2117681036 cites W2126644478 @default.
• W2117681036 cites W2130850997 @default.
• W2117681036 cites W2132417094 @default.
• W2117681036 cites W2137262613 @default.
• W2117681036 cites W2139266935 @default.
• W2117681036 cites W2149335010 @default.
• W2117681036 cites W2161558889 @default.
• W2117681036 cites W2163828009 @default.
• W2117681036 cites W2166079348 @default.
• W2117681036 cites W2317442966 @default.
• W2117681036 cites W2318180004 @default.
• W2117681036 cites W2321852728 @default.
• W2117681036 cites W2336149973 @default.
• W2117681036 doi "https://doi.org/10.1128/aac.44.9.2475-2484.2000" @default.
• W2117681036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/90088" @default.
• W2117681036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10952598" @default.
• W2117681036 hasPublicationYear "2000" @default.
• W2117681036 type Work @default.
• W2117681036 sameAs 2117681036 @default.
• W2117681036 citedByCount "258" @default.
• W2117681036 countsByYear W21176810362012 @default.
• W2117681036 countsByYear W21176810362013 @default.
• W2117681036 countsByYear W21176810362014 @default.
• W2117681036 countsByYear W21176810362015 @default.
• W2117681036 countsByYear W21176810362016 @default.
• W2117681036 countsByYear W21176810362017 @default.
• W2117681036 countsByYear W21176810362018 @default.
• W2117681036 countsByYear W21176810362019 @default.
• W2117681036 countsByYear W21176810362020 @default.
• W2117681036 countsByYear W21176810362021 @default.
• W2117681036 countsByYear W21176810362022 @default.
• W2117681036 countsByYear W21176810362023 @default.
• W2117681036 crossrefType "journal-article" @default.
• W2117681036 hasAuthorship W2117681036A5003876104 @default.
• W2117681036 hasAuthorship W2117681036A5005852106 @default.
• W2117681036 hasAuthorship W2117681036A5015708802 @default.
• W2117681036 hasAuthorship W2117681036A5033716785 @default.
• W2117681036 hasAuthorship W2117681036A5033772097 @default.
• W2117681036 hasAuthorship W2117681036A5040842397 @default.
• W2117681036 hasAuthorship W2117681036A5043803149 @default.
• W2117681036 hasAuthorship W2117681036A5051935108 @default.
• W2117681036 hasAuthorship W2117681036A5064778713 @default.
• W2117681036 hasAuthorship W2117681036A5076639320 @default.
• W2117681036 hasAuthorship W2117681036A5076683227 @default.
• W2117681036 hasAuthorship W2117681036A5078612967 @default.
• W2117681036 hasAuthorship W2117681036A5078740089 @default.
• W2117681036 hasAuthorship W2117681036A5085875099 @default.
• W2117681036 hasAuthorship W2117681036A5086208718 @default.
• W2117681036 hasAuthorship W2117681036A5088470341 @default.
• W2117681036 hasBestOaLocation W21176810361 @default.
• W2117681036 hasConcept C104317684 @default.
• W2117681036 hasConcept C142462285 @default.
• W2117681036 hasConcept C156719811 @default.
• W2117681036 hasConcept C159047783 @default.
• W2117681036 hasConcept C2522874641 @default.
• W2117681036 hasConcept C2777210460 @default.
• W2117681036 hasConcept C2777351918 @default.
• W2117681036 hasConcept C2777869810 @default.
• W2117681036 hasConcept C2779889181 @default.

• next