FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119543398> ?p ?o ?g. }

• W2119543398 endingPage "199" @default.
• W2119543398 startingPage "187" @default.
• W2119543398 abstract "AGN 201904-Z is a new, slowly absorbed, acid-stable pro-proton pump inhibitor (pro-PPI) rapidly converted to omeprazole in the systemic circulation giving a prolonged residence time.To investigate pharmacodynamics and pharmacokinetics of AGN 201904-Z compared to esomeprazole.A randomized, open-label, parallel group, investigator-blinded intragastric pH study was conducted in 24 healthy Helicobacter pylori negative male volunteers. AGN 201904-Z enteric-coated capsules (600 mg/day) or esomeprazole delayed-release tablets (40 mg/day) were administered for 5 days. Twenty-four-hour intragastric pH recordings were acquired at baseline, days 1, 3 and 5 with blood levels of omeprazole, AGN 201904-Z and gastrin.On day 1, median nocturnal pH and proportion of nocturnal time with pH >or=4 and 24-h and nocturnal time pH >or=5 were significantly higher with AGN 201904-Z than esomeprazole. At day 5, 24-h and median nocturnal pH were significantly higher for AGN 201904-Z than esomeprazole (P < 0.0001). There was also a marked reduction in periods of nocturnal pH <4.0. Area under curve of the AGN 201904-Z active metabolite (omeprazole) in the blood was twice that of esomeprazole at day 5.AGN 201904-Z produced a significantly greater and more prolonged acid suppression than esomeprazole, and nocturnal acid suppression was more prolonged over all 5 days. AGN 201904-Z should provide true once-a-day treatment and better clinical efficacy than current PPIs." @default.
• W2119543398 created "2016-06-24" @default.
• W2119543398 creator A5000433929 @default.
• W2119543398 creator A5008732364 @default.
• W2119543398 creator A5009108071 @default.
• W2119543398 creator A5014881341 @default.
• W2119543398 creator A5023190421 @default.
• W2119543398 creator A5028863923 @default.
• W2119543398 creator A5038491035 @default.
• W2119543398 creator A5057185561 @default.
• W2119543398 creator A5059184078 @default.
• W2119543398 creator A5085871367 @default.
• W2119543398 date "2008-06-28" @default.
• W2119543398 modified "2023-10-15" @default.
• W2119543398 title "Predictable prolonged suppression of gastric acidity with a novel proton pump inhibitor, AGN 201904-Z" @default.
• W2119543398 cites W1949812259 @default.
• W2119543398 cites W1971705529 @default.
• W2119543398 cites W1990846755 @default.
• W2119543398 cites W1992734182 @default.
• W2119543398 cites W2015075258 @default.
• W2119543398 cites W2016542167 @default.
• W2119543398 cites W2033624426 @default.
• W2119543398 cites W2040063587 @default.
• W2119543398 cites W2061056188 @default.
• W2119543398 cites W2069326833 @default.
• W2119543398 cites W2085023173 @default.
• W2119543398 cites W2086150474 @default.
• W2119543398 cites W2112774005 @default.
• W2119543398 cites W2137245024 @default.
• W2119543398 cites W2147199669 @default.
• W2119543398 cites W2151869041 @default.
• W2119543398 cites W23158707 @default.
• W2119543398 cites W25460674 @default.
• W2119543398 cites W4238774668 @default.
• W2119543398 cites W4249481007 @default.
• W2119543398 doi "https://doi.org/10.1111/j.1365-2036.2008.03725.x" @default.
• W2119543398 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4505925" @default.
• W2119543398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18445141" @default.
• W2119543398 hasPublicationYear "2008" @default.
• W2119543398 type Work @default.
• W2119543398 sameAs 2119543398 @default.
• W2119543398 citedByCount "42" @default.
• W2119543398 countsByYear W21195433982012 @default.
• W2119543398 countsByYear W21195433982013 @default.
• W2119543398 countsByYear W21195433982014 @default.
• W2119543398 countsByYear W21195433982015 @default.
• W2119543398 countsByYear W21195433982016 @default.
• W2119543398 countsByYear W21195433982019 @default.
• W2119543398 countsByYear W21195433982022 @default.
• W2119543398 crossrefType "journal-article" @default.
• W2119543398 hasAuthorship W2119543398A5000433929 @default.
• W2119543398 hasAuthorship W2119543398A5008732364 @default.
• W2119543398 hasAuthorship W2119543398A5009108071 @default.
• W2119543398 hasAuthorship W2119543398A5014881341 @default.
• W2119543398 hasAuthorship W2119543398A5023190421 @default.
• W2119543398 hasAuthorship W2119543398A5028863923 @default.
• W2119543398 hasAuthorship W2119543398A5038491035 @default.
• W2119543398 hasAuthorship W2119543398A5057185561 @default.
• W2119543398 hasAuthorship W2119543398A5059184078 @default.
• W2119543398 hasAuthorship W2119543398A5085871367 @default.
• W2119543398 hasBestOaLocation W21195433981 @default.
• W2119543398 hasConcept C111113717 @default.
• W2119543398 hasConcept C112705442 @default.
• W2119543398 hasConcept C126322002 @default.
• W2119543398 hasConcept C2777334680 @default.
• W2119543398 hasConcept C2777498785 @default.
• W2119543398 hasConcept C2777504413 @default.
• W2119543398 hasConcept C2778204628 @default.
• W2119543398 hasConcept C2779422922 @default.
• W2119543398 hasConcept C2781025758 @default.
• W2119543398 hasConcept C71924100 @default.
• W2119543398 hasConcept C90924648 @default.
• W2119543398 hasConcept C98274493 @default.
• W2119543398 hasConceptScore W2119543398C111113717 @default.
• W2119543398 hasConceptScore W2119543398C112705442 @default.
• W2119543398 hasConceptScore W2119543398C126322002 @default.
• W2119543398 hasConceptScore W2119543398C2777334680 @default.
• W2119543398 hasConceptScore W2119543398C2777498785 @default.
• W2119543398 hasConceptScore W2119543398C2777504413 @default.
• W2119543398 hasConceptScore W2119543398C2778204628 @default.
• W2119543398 hasConceptScore W2119543398C2779422922 @default.
• W2119543398 hasConceptScore W2119543398C2781025758 @default.
• W2119543398 hasConceptScore W2119543398C71924100 @default.
• W2119543398 hasConceptScore W2119543398C90924648 @default.
• W2119543398 hasConceptScore W2119543398C98274493 @default.
• W2119543398 hasIssue "2" @default.
• W2119543398 hasLocation W21195433981 @default.
• W2119543398 hasLocation W21195433982 @default.
• W2119543398 hasLocation W21195433983 @default.
• W2119543398 hasLocation W21195433984 @default.
• W2119543398 hasOpenAccess W2119543398 @default.
• W2119543398 hasPrimaryLocation W21195433981 @default.
• W2119543398 hasRelatedWork W1547176249 @default.
• W2119543398 hasRelatedWork W175488739 @default.
• W2119543398 hasRelatedWork W1976781864 @default.
• W2119543398 hasRelatedWork W2004737166 @default.
• W2119543398 hasRelatedWork W2004748608 @default.
• W2119543398 hasRelatedWork W2092641257 @default.

• next