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• W2121036185 abstract "Immune parameters were analyzed in peripheral blood mononuclear cells (PBMC) and cervical mucosa biopsy specimens of human immunodeficiency virus (HIV)-seronegative women sexually exposed to HIV (exposed seronegative [ESN]), HIV-infected women, and healthy women without HIV exposure. HIV was not detected in PBMC or cervical mucosa biopsy specimens of ESN women. However, interleukin (IL)-6, IL-10, IL-12, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha and -beta mRNA were elevated in PBMC and cervical mucosa biopsy specimens of ESN and HIV-infected women; CCR5 and CXCR4 mRNA were augmented in cervical mucosa biopsy specimens, but not in PBMC, of ESN and HIV-infected women; HIV-specific IFN-gamma-secreting cells were detected in vaginal washes of ESN and HIV-infected women; and phenotypic alterations were present in PBMC of ESN women. These results suggest that active HIV infection is not required for T cell activation; immune alterations occur in women in whom HIV infection cannot be detected virologically or clinically." @default.
• W2121036185 created "2016-06-24" @default.
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• W2121036185 date "2000-11-01" @default.
• W2121036185 modified "2023-10-17" @default.
• W2121036185 title "Mucosal and Systemic Immune Activation Is Present in Human Immunodeficiency Virus–Exposed Seronegative Women" @default.
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• W2121036185 doi "https://doi.org/10.1086/315873" @default.
• W2121036185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11023460" @default.
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