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• W2121422182 abstract "Withangulatin A (WA), an active component isolated from Physalis angulata L., has been reported to possess anti-tumor and trypanocidal activities in model systems via multiple biochemical mechanisms. The aim of this study is to investigate its anti-inflammatory potential and the possible underlying mechanisms. In the current study, WA significantly suppressed mice T lymphocytes proliferation stimulated with LPS in a dose- and time-dependent manner and inhibited pro-inflammation cytokines (IL-2, IFN-γ, and IL-6) dramatically. Moreover, WA targeted inhibited COX-2 expression mediated by MAPKs and NF-κB nuclear translocation pathways in mice T lymphocytes, and this result was further confirmed by the COX-1/2 luciferase reporter assay. Intriguingly, administration of WA inhibited the extent of mice ear swelling and decreased pro-inflammatory cytokines production in mice blood serum. Based on these evidences, WA influences the mice T lymphocytes function through targeted inhibiting COX-2 expression via MAPKs and NF-κB nuclear translocation signaling pathways, and this would make WA a strong candidate for further study as an anti-inflammatory agent. J. Cell. Biochem. 109: 532–541, 2010. © 2009 Wiley-Liss, Inc." @default.
• W2121422182 created "2016-06-24" @default.
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• W2121422182 date "2009-01-01" @default.
• W2121422182 modified "2023-10-11" @default.
• W2121422182 title "Anti-inflammatory function of Withangulatin A by targeted inhibiting COX-2 expression via MAPK and NF-κB pathways" @default.
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• W2121422182 doi "https://doi.org/10.1002/jcb.22430" @default.
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