FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125103653> ?p ?o ?g. }

• W2125103653 endingPage "371" @default.
• W2125103653 startingPage "361" @default.
• W2125103653 abstract "The loss of tuberin, the tuberous sclerosis-2 (Tsc-2) gene product, is associated with cytoplasmic mislocalization of p27 in uterine leiomyomas derived from Eker rats (Tsc-2(EK/+)) and in human metastatic renal cell carcinoma tissue. Signaling associated with cytoplasmic mislocalization of p27 in renal cancer is relatively unknown. Renal tumors derived from 2,3,5-tris-(glutathion-S-yl)hydroquinone (TGHQ)-treated Tsc-2(EK/+) rats, and null for tuberin, display elevated nuclear and cytosolic p27, with parallel increases in cytosolic cyclin D1 levels. Similar changes are observed in TGHQ-transformed renal epithelial cells derived from Tsc-2(EK/+) rats (QTRRE cells), which, in addition to the cytoplasmic mislocalization of p27 and cyclin D1, exhibit high ERK, B-Raf, and Raf-1 kinase activity. Renal tumor xenografts, derived from subcutaneous injection of QTRRE cells into nude mice, also display increases in cytosolic mislocalization of p27 and cyclin D1. Dibutyryl cAMP and/or phosphodiesterase inhibitors (PIs; pentoxifylline or theophylline) increase Rap1B activation, B-Raf kinase activity, and cytosolic p27/cyclin D1 protein levels in QTRRE cells. Inhibition of Raf kinases with either sorafenib or B-Raf small interfering RNA (siRNA) caused a mitogen-activated protein kinase-mediated downregulation of p27. Moreover, decreases in cyclin D1 were also associated with p27 siRNA knockdown in QTRRE cells. Finally, theophylline-mediated increases in p27 and cyclin D1 were attenuated by sorafenib, which modulated Raf/MEK/ERK signaling. Collectively, these data suggest that the cAMP/Rap1B/B-Raf pathway modulates the expression of p27 and the cytoplasmic mislocalization of p27-cyclin D1 in tuberous sclerosis gene-regulated-renal cancer. Therefore, the loss of tuberin and engagement of the cAMP pathway may independently direct p27-cyclin D1 cytosolic stabilization during renal tumor formation." @default.
• W2125103653 created "2016-06-24" @default.
• W2125103653 creator A5037659718 @default.
• W2125103653 creator A5040933810 @default.
• W2125103653 creator A5059967974 @default.
• W2125103653 creator A5060909286 @default.
• W2125103653 creator A5077421484 @default.
• W2125103653 creator A5086522629 @default.
• W2125103653 date "2011-06-20" @default.
• W2125103653 modified "2023-09-28" @default.
• W2125103653 title "cAMP-Dependent Cytosolic Mislocalization of p27kip-Cyclin D1 During Quinol-Thioether–Induced Tuberous Sclerosis Renal Cell Carcinoma" @default.
• W2125103653 cites W1541757144 @default.
• W2125103653 cites W1558846872 @default.
• W2125103653 cites W1967200244 @default.
• W2125103653 cites W1968793235 @default.
• W2125103653 cites W1969249989 @default.
• W2125103653 cites W1973167868 @default.
• W2125103653 cites W1975131304 @default.
• W2125103653 cites W1976184018 @default.
• W2125103653 cites W1976849281 @default.
• W2125103653 cites W1977532087 @default.
• W2125103653 cites W1979013732 @default.
• W2125103653 cites W1980754624 @default.
• W2125103653 cites W1981517713 @default.
• W2125103653 cites W1991930853 @default.
• W2125103653 cites W2004068588 @default.
• W2125103653 cites W2005254421 @default.
• W2125103653 cites W2005942192 @default.
• W2125103653 cites W2009713859 @default.
• W2125103653 cites W2010160635 @default.
• W2125103653 cites W2013929500 @default.
• W2125103653 cites W2020820568 @default.
• W2125103653 cites W2028509054 @default.
• W2125103653 cites W2029810183 @default.
• W2125103653 cites W2031671719 @default.
• W2125103653 cites W2032546548 @default.
• W2125103653 cites W2032945178 @default.
• W2125103653 cites W2036307706 @default.
• W2125103653 cites W2038662992 @default.
• W2125103653 cites W2041405504 @default.
• W2125103653 cites W2044312503 @default.
• W2125103653 cites W2045102427 @default.
• W2125103653 cites W2046024621 @default.
• W2125103653 cites W2060141022 @default.
• W2125103653 cites W2070349030 @default.
• W2125103653 cites W2071870936 @default.
• W2125103653 cites W2072619403 @default.
• W2125103653 cites W2073482997 @default.
• W2125103653 cites W2082131764 @default.
• W2125103653 cites W2084488354 @default.
• W2125103653 cites W2093315880 @default.
• W2125103653 cites W2095934203 @default.
• W2125103653 cites W2098817749 @default.
• W2125103653 cites W2100772783 @default.
• W2125103653 cites W2100790734 @default.
• W2125103653 cites W2101076673 @default.
• W2125103653 cites W2106337632 @default.
• W2125103653 cites W2106410563 @default.
• W2125103653 cites W2107630487 @default.
• W2125103653 cites W2111613650 @default.
• W2125103653 cites W2115692032 @default.
• W2125103653 cites W2121619780 @default.
• W2125103653 cites W2128732250 @default.
• W2125103653 cites W2128879599 @default.
• W2125103653 cites W2139550352 @default.
• W2125103653 cites W2146451974 @default.
• W2125103653 cites W2146946054 @default.
• W2125103653 cites W2147392364 @default.
• W2125103653 cites W2152398347 @default.
• W2125103653 cites W2158104172 @default.
• W2125103653 cites W2163004699 @default.
• W2125103653 cites W2170024216 @default.
• W2125103653 cites W2319829135 @default.
• W2125103653 doi "https://doi.org/10.1093/toxsci/kfr118" @default.
• W2125103653 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3155088" @default.
• W2125103653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21693435" @default.
• W2125103653 hasPublicationYear "2011" @default.
• W2125103653 type Work @default.
• W2125103653 sameAs 2125103653 @default.
• W2125103653 citedByCount "10" @default.
• W2125103653 countsByYear W21251036532013 @default.
• W2125103653 countsByYear W21251036532015 @default.
• W2125103653 countsByYear W21251036532018 @default.
• W2125103653 countsByYear W21251036532019 @default.
• W2125103653 countsByYear W21251036532020 @default.
• W2125103653 countsByYear W21251036532021 @default.
• W2125103653 countsByYear W21251036532022 @default.
• W2125103653 crossrefType "journal-article" @default.
• W2125103653 hasAuthorship W2125103653A5037659718 @default.
• W2125103653 hasAuthorship W2125103653A5040933810 @default.
• W2125103653 hasAuthorship W2125103653A5059967974 @default.
• W2125103653 hasAuthorship W2125103653A5060909286 @default.
• W2125103653 hasAuthorship W2125103653A5077421484 @default.
• W2125103653 hasAuthorship W2125103653A5086522629 @default.
• W2125103653 hasBestOaLocation W21251036531 @default.
• W2125103653 hasConcept C184235292 @default.
• W2125103653 hasConcept C185592680 @default.
• W2125103653 hasConcept C190283241 @default.

• next