FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127377844> ?p ?o ?g. }

• W2127377844 endingPage "4120" @default.
• W2127377844 startingPage "4112" @default.
• W2127377844 abstract "2,3-Seco-dioic acids derived from four different triterpene skeletons were prepared and evaluated for their anti-HIV-1 protease activity. Two A-seco derivatives showed potent inhibitory activity against HIV-1 protease (3c and 3e, IC50 5.7 and 3.9 μM, respectively), while four other derivatives showed moderate to weak inhibition (3a, 3b, 3d and 3f, IC50 15.7–88.1 μM). The combination of a 2,3-seco-2,3-dioic acid functional group in ring A and a free acid group at C-28 or C-30 significantly enhanced HIV-1 protease inhibitory activity (3a, 3c–3e, IC50 3.9–17.6 μM). On the other hand, all A-seco derivatives were found to be very weak inhibitors of HCV, renin and trypsin proteases (IC50 > 80 μM). These findings indicate that A-seco triterpenes with a carboxyl group at C-28 or C-30 are novel and highly selective HIV-1 protease inhibitors." @default.
• W2127377844 created "2016-06-24" @default.
• W2127377844 creator A5002986160 @default.
• W2127377844 creator A5028862319 @default.
• W2127377844 creator A5038871110 @default.
• W2127377844 date "2009-10-01" @default.
• W2127377844 modified "2023-10-14" @default.
• W2127377844 title "Synthesis and evaluation of A-seco type triterpenoids for anti-HIV-1protease activity" @default.
• W2127377844 cites W12588242 @default.
• W2127377844 cites W1963633468 @default.
• W2127377844 cites W1968351476 @default.
• W2127377844 cites W1970809758 @default.
• W2127377844 cites W1976601149 @default.
• W2127377844 cites W1977791059 @default.
• W2127377844 cites W1979377741 @default.
• W2127377844 cites W1995260211 @default.
• W2127377844 cites W2006665313 @default.
• W2127377844 cites W2009992010 @default.
• W2127377844 cites W2010111657 @default.
• W2127377844 cites W2013816495 @default.
• W2127377844 cites W2017225588 @default.
• W2127377844 cites W2017462823 @default.
• W2127377844 cites W2019035381 @default.
• W2127377844 cites W2020540736 @default.
• W2127377844 cites W2023574313 @default.
• W2127377844 cites W2039991473 @default.
• W2127377844 cites W2045440270 @default.
• W2127377844 cites W2049853842 @default.
• W2127377844 cites W2050891654 @default.
• W2127377844 cites W2054206985 @default.
• W2127377844 cites W2056814754 @default.
• W2127377844 cites W2057901597 @default.
• W2127377844 cites W2086233644 @default.
• W2127377844 cites W2091937293 @default.
• W2127377844 cites W2121844775 @default.
• W2127377844 cites W2145461177 @default.
• W2127377844 cites W2161855026 @default.
• W2127377844 cites W2172007839 @default.
• W2127377844 cites W2261556321 @default.
• W2127377844 cites W2949175151 @default.
• W2127377844 doi "https://doi.org/10.1016/j.ejmech.2009.05.002" @default.
• W2127377844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19493591" @default.
• W2127377844 hasPublicationYear "2009" @default.
• W2127377844 type Work @default.
• W2127377844 sameAs 2127377844 @default.
• W2127377844 citedByCount "43" @default.
• W2127377844 countsByYear W21273778442012 @default.
• W2127377844 countsByYear W21273778442013 @default.
• W2127377844 countsByYear W21273778442014 @default.
• W2127377844 countsByYear W21273778442015 @default.
• W2127377844 countsByYear W21273778442016 @default.
• W2127377844 countsByYear W21273778442017 @default.
• W2127377844 countsByYear W21273778442018 @default.
• W2127377844 countsByYear W21273778442019 @default.
• W2127377844 countsByYear W21273778442020 @default.
• W2127377844 countsByYear W21273778442022 @default.
• W2127377844 crossrefType "journal-article" @default.
• W2127377844 hasAuthorship W2127377844A5002986160 @default.
• W2127377844 hasAuthorship W2127377844A5028862319 @default.
• W2127377844 hasAuthorship W2127377844A5038871110 @default.
• W2127377844 hasConcept C107585567 @default.
• W2127377844 hasConcept C142462285 @default.
• W2127377844 hasConcept C142724271 @default.
• W2127377844 hasConcept C159047783 @default.
• W2127377844 hasConcept C181199279 @default.
• W2127377844 hasConcept C182220744 @default.
• W2127377844 hasConcept C185592680 @default.
• W2127377844 hasConcept C202751555 @default.
• W2127377844 hasConcept C204787440 @default.
• W2127377844 hasConcept C2776714187 @default.
• W2127377844 hasConcept C2776980637 @default.
• W2127377844 hasConcept C2777583353 @default.
• W2127377844 hasConcept C2777752497 @default.
• W2127377844 hasConcept C2780527577 @default.
• W2127377844 hasConcept C2781143361 @default.
• W2127377844 hasConcept C2993143319 @default.
• W2127377844 hasConcept C3013748606 @default.
• W2127377844 hasConcept C55493867 @default.
• W2127377844 hasConcept C71240020 @default.
• W2127377844 hasConcept C71924100 @default.
• W2127377844 hasConcept C86803240 @default.
• W2127377844 hasConceptScore W2127377844C107585567 @default.
• W2127377844 hasConceptScore W2127377844C142462285 @default.
• W2127377844 hasConceptScore W2127377844C142724271 @default.
• W2127377844 hasConceptScore W2127377844C159047783 @default.
• W2127377844 hasConceptScore W2127377844C181199279 @default.
• W2127377844 hasConceptScore W2127377844C182220744 @default.
• W2127377844 hasConceptScore W2127377844C185592680 @default.
• W2127377844 hasConceptScore W2127377844C202751555 @default.
• W2127377844 hasConceptScore W2127377844C204787440 @default.
• W2127377844 hasConceptScore W2127377844C2776714187 @default.
• W2127377844 hasConceptScore W2127377844C2776980637 @default.
• W2127377844 hasConceptScore W2127377844C2777583353 @default.
• W2127377844 hasConceptScore W2127377844C2777752497 @default.
• W2127377844 hasConceptScore W2127377844C2780527577 @default.
• W2127377844 hasConceptScore W2127377844C2781143361 @default.
• W2127377844 hasConceptScore W2127377844C2993143319 @default.
• W2127377844 hasConceptScore W2127377844C3013748606 @default.

• next