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• W2130239194 abstract "Proper functioning of the ovary is critical to maintain fertility and overall health, and ovarian function depends on the maintenance and normal development of ovarian follicles. This review presents evidence about the potential impact of oxidative stress on the well-being of primordial, growing and preovulatory follicles, as well as oocytes and early embryos, examining cell types and molecular targets. Limited data from genetically modified mouse models suggest that several antioxidant enzymes that protect cells from reactive oxygen species (ROS) may play important roles in follicular development and/or survival. Exposures to agents known to cause oxidative stress, such as gamma irradiation, chemotherapeutic drugs, or polycyclic aromatic hydrocarbons, induce rapid primordial follicle loss; however, the mechanistic role of ROS has received limited attention. In contrast, ROS may play an important role in the initiation of apoptosis in antral follicles. Depletion of glutathione leads to atresia of antral follicles in vivo and apoptosis of granulosa cells in cultured antral follicles. Chemicals, such as cyclophosphamide, dimethylbenzanthracene, and methoxychlor, increase proapoptotic signals, preceded by increased ROS and signs of oxidative stress, and cotreatment with antioxidants is protective. In oocytes, glutathione levels change rapidly during progression of meiosis and early embryonic development, and high oocyte glutathione at the time of fertilization is required for male pronucleus formation and for embryonic development to the blastocyst stage. Because current evidence suggests that oxidative stress can have significant negative impacts on female fertility and gamete health, dietary or pharmacological intervention may prove to be effective strategies to protect female fertility." @default.
• W2130239194 created "2016-06-24" @default.
• W2130239194 creator A5011484074 @default.
• W2130239194 creator A5039209354 @default.
• W2130239194 creator A5043257601 @default.
• W2130239194 date "2012-02-01" @default.
• W2130239194 modified "2023-10-16" @default.
• W2130239194 title "Roles of Reactive Oxygen Species and Antioxidants in Ovarian Toxicity1" @default.
• W2130239194 cites W1969665448 @default.
• W2130239194 cites W1970240791 @default.
• W2130239194 cites W1970448558 @default.
• W2130239194 cites W1973211941 @default.
• W2130239194 cites W1973801976 @default.
• W2130239194 cites W1976477577 @default.
• W2130239194 cites W1976842211 @default.
• W2130239194 cites W1977221535 @default.
• W2130239194 cites W1979840983 @default.
• W2130239194 cites W1982487922 @default.
• W2130239194 cites W1995565650 @default.
• W2130239194 cites W1996833241 @default.
• W2130239194 cites W2001860274 @default.
• W2130239194 cites W2002304438 @default.
• W2130239194 cites W2003337850 @default.
• W2130239194 cites W2003706186 @default.
• W2130239194 cites W2006313098 @default.
• W2130239194 cites W2008531519 @default.
• W2130239194 cites W2011582935 @default.
• W2130239194 cites W2011887762 @default.
• W2130239194 cites W2011901078 @default.
• W2130239194 cites W2014262114 @default.
• W2130239194 cites W2017973159 @default.
• W2130239194 cites W2018374650 @default.
• W2130239194 cites W2023627397 @default.
• W2130239194 cites W2024814453 @default.
• W2130239194 cites W2024869728 @default.
• W2130239194 cites W2025879742 @default.
• W2130239194 cites W2026105521 @default.
• W2130239194 cites W2026459212 @default.
• W2130239194 cites W2028484565 @default.
• W2130239194 cites W2028921122 @default.
• W2130239194 cites W2029367870 @default.
• W2130239194 cites W2029490482 @default.
• W2130239194 cites W2029863590 @default.
• W2130239194 cites W2029928280 @default.
• W2130239194 cites W2031544682 @default.
• W2130239194 cites W2034005931 @default.
• W2130239194 cites W2034600844 @default.
• W2130239194 cites W2038758189 @default.
• W2130239194 cites W2041879182 @default.
• W2130239194 cites W2044353940 @default.
• W2130239194 cites W2045082915 @default.
• W2130239194 cites W2047078852 @default.
• W2130239194 cites W2048168782 @default.
• W2130239194 cites W2050406486 @default.
• W2130239194 cites W2055419513 @default.
• W2130239194 cites W2059219100 @default.
• W2130239194 cites W2061741820 @default.
• W2130239194 cites W2064600250 @default.
• W2130239194 cites W2069895572 @default.
• W2130239194 cites W2070466664 @default.
• W2130239194 cites W2071299867 @default.
• W2130239194 cites W2071662762 @default.
• W2130239194 cites W2073472170 @default.
• W2130239194 cites W2074002921 @default.
• W2130239194 cites W2078136787 @default.
• W2130239194 cites W2080997681 @default.
• W2130239194 cites W2082000694 @default.
• W2130239194 cites W2083733953 @default.
• W2130239194 cites W2085707821 @default.
• W2130239194 cites W2091470678 @default.
• W2130239194 cites W2092195942 @default.
• W2130239194 cites W2093194030 @default.
• W2130239194 cites W2094931304 @default.
• W2130239194 cites W2096599835 @default.
• W2130239194 cites W2097206260 @default.
• W2130239194 cites W2100468765 @default.
• W2130239194 cites W2100817870 @default.
• W2130239194 cites W2101228550 @default.
• W2130239194 cites W2104136026 @default.
• W2130239194 cites W2105162966 @default.
• W2130239194 cites W2105171996 @default.
• W2130239194 cites W2106236974 @default.
• W2130239194 cites W2109012795 @default.
• W2130239194 cites W2112276431 @default.
• W2130239194 cites W2123840670 @default.
• W2130239194 cites W2125409388 @default.
• W2130239194 cites W2127620446 @default.
• W2130239194 cites W2128975535 @default.
• W2130239194 cites W2130631511 @default.
• W2130239194 cites W2131280745 @default.
• W2130239194 cites W2135350756 @default.
• W2130239194 cites W2135935753 @default.
• W2130239194 cites W2138165502 @default.
• W2130239194 cites W2138368231 @default.
• W2130239194 cites W2139588608 @default.
• W2130239194 cites W2139784811 @default.
• W2130239194 cites W2140355945 @default.
• W2130239194 cites W2142033690 @default.
• W2130239194 cites W2142401933 @default.
• W2130239194 cites W2143556838 @default.

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