Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130294237> ?p ?o ?g. }
- W2130294237 endingPage "434" @default.
- W2130294237 startingPage "423" @default.
- W2130294237 abstract "In the USA, fetal alcohol syndrome (FAS) is the leading known cause of mental retardation. FAS is estimated to affect 4000 infants yearly in the USA with an additional 7000 children suffering various forms of fetal alcohol effects in the absence of the full syndrome. A comparable incidence would be expected in other industrialized countries, but essentially no data are available from either developing or third world countries. An understanding of the biochemical causes of FAS has been slow to develop, but progress has been made toward a molecular causation theory of FAS. This paper summarizes much of the current work as to the effects of fetal ethanol exposure on mitotic and metabolic parameters as well as ethanol's effect on the cellular signalling pathways thought to regulate these processes. Based upon these studies, it is apparent that exposure of embryonic tissue to ethanol results in decreased growth and that alcohol adversely affects a multitude of cellular functions critical for the growth of the developing organism, including inhibition of protein and DNA synthesis. In addition, ethanol alters the uptake of critical nutrients such as glucose and amino acids and causes changes in several kinase-mediated signal transduction pathways that regulate these biochemical processes." @default.
- W2130294237 created "2016-06-24" @default.
- W2130294237 creator A5005842531 @default.
- W2130294237 creator A5015401905 @default.
- W2130294237 date "1997-07-01" @default.
- W2130294237 modified "2023-09-27" @default.
- W2130294237 title "METABOLIC AND MITOTIC CHANGES ASSOCIATED WITH THE FETAL ALCOHOL SYNDROME" @default.
- W2130294237 cites W1191882190 @default.
- W2130294237 cites W1257903918 @default.
- W2130294237 cites W148785554 @default.
- W2130294237 cites W1491958169 @default.
- W2130294237 cites W1522904635 @default.
- W2130294237 cites W1525229364 @default.
- W2130294237 cites W1531933505 @default.
- W2130294237 cites W1532143214 @default.
- W2130294237 cites W1552207560 @default.
- W2130294237 cites W1690102379 @default.
- W2130294237 cites W1765368939 @default.
- W2130294237 cites W1838741822 @default.
- W2130294237 cites W1853740807 @default.
- W2130294237 cites W1898250799 @default.
- W2130294237 cites W1903394488 @default.
- W2130294237 cites W192756239 @default.
- W2130294237 cites W1955609438 @default.
- W2130294237 cites W1966055833 @default.
- W2130294237 cites W1967285990 @default.
- W2130294237 cites W1968690350 @default.
- W2130294237 cites W1970880349 @default.
- W2130294237 cites W1971095258 @default.
- W2130294237 cites W1973003994 @default.
- W2130294237 cites W1976720824 @default.
- W2130294237 cites W1979436361 @default.
- W2130294237 cites W1981209561 @default.
- W2130294237 cites W1982648767 @default.
- W2130294237 cites W1983802476 @default.
- W2130294237 cites W1984614010 @default.
- W2130294237 cites W1986475011 @default.
- W2130294237 cites W1991630897 @default.
- W2130294237 cites W1991972636 @default.
- W2130294237 cites W1992472345 @default.
- W2130294237 cites W1993354400 @default.
- W2130294237 cites W1993639141 @default.
- W2130294237 cites W2001585719 @default.
- W2130294237 cites W2001692359 @default.
- W2130294237 cites W2001852168 @default.
- W2130294237 cites W2001961640 @default.
- W2130294237 cites W2002134543 @default.
- W2130294237 cites W2008898641 @default.
- W2130294237 cites W2010891643 @default.
- W2130294237 cites W2012184766 @default.
- W2130294237 cites W2015760542 @default.
- W2130294237 cites W2019090383 @default.
- W2130294237 cites W2022387050 @default.
- W2130294237 cites W2022953270 @default.
- W2130294237 cites W2024794228 @default.
- W2130294237 cites W2028382039 @default.
- W2130294237 cites W2031588343 @default.
- W2130294237 cites W2032044962 @default.
- W2130294237 cites W2033082718 @default.
- W2130294237 cites W2036457593 @default.
- W2130294237 cites W2036704058 @default.
- W2130294237 cites W2037913619 @default.
- W2130294237 cites W2038858164 @default.
- W2130294237 cites W2041090971 @default.
- W2130294237 cites W2043498565 @default.
- W2130294237 cites W2046325853 @default.
- W2130294237 cites W2046446647 @default.
- W2130294237 cites W2048382344 @default.
- W2130294237 cites W2051770482 @default.
- W2130294237 cites W2053038903 @default.
- W2130294237 cites W2055622775 @default.
- W2130294237 cites W2055830509 @default.
- W2130294237 cites W2056706044 @default.
- W2130294237 cites W2058851412 @default.
- W2130294237 cites W2059201517 @default.
- W2130294237 cites W2062415677 @default.
- W2130294237 cites W2063145932 @default.
- W2130294237 cites W2065004148 @default.
- W2130294237 cites W2067776958 @default.
- W2130294237 cites W2068049822 @default.
- W2130294237 cites W2069416081 @default.
- W2130294237 cites W2069459842 @default.
- W2130294237 cites W2070289377 @default.
- W2130294237 cites W2071117135 @default.
- W2130294237 cites W2073255901 @default.
- W2130294237 cites W2074247654 @default.
- W2130294237 cites W2075069609 @default.
- W2130294237 cites W2076101518 @default.
- W2130294237 cites W2076962597 @default.
- W2130294237 cites W2077940526 @default.
- W2130294237 cites W2078190970 @default.
- W2130294237 cites W2078258767 @default.
- W2130294237 cites W2082521269 @default.
- W2130294237 cites W2083420861 @default.
- W2130294237 cites W2083729530 @default.
- W2130294237 cites W2084995030 @default.
- W2130294237 cites W2086313404 @default.
- W2130294237 cites W2087078668 @default.