FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131036658> ?p ?o ?g. }

• W2131036658 endingPage "813" @default.
• W2131036658 startingPage "804" @default.
• W2131036658 abstract "HE2, a gene expressed specifically in human epididymis, gives rise to multiple mRNAs that encode a group of small cationic secretory peptides. Localization of HE2 within the defensin gene cluster and prediction that beta-defensin-like modules exist suggest that these peptides have antimicrobial activity and represent components of the innate epithelial defense system of the epididymal duct. Reverse transcription-polymerase chain reaction analysis confirmed the occurrence of eight human HE2-derived transcripts, including minor mRNA variants, that had previously been shown only in animal species. Employing isoform-specific antibodies against the predicted HE2 products, multiple 4- to 8-kDa peptides were detected in human epididymal epithelium, epididymal fluid, and ejaculate. N-terminal microsequencing has suggested a proteolytic processing of these peptides by a furin-like proprotein convertase, which cleaves a propiece from the longer precursor peptides. HE2alpha and HE2beta1, representing major peptide isoforms in the human epididymis, were recombinantly expressed, and their susceptibility to furin cleavage was demonstrated in vitro and in vivo. Processed recombinant peptides and chemosynthetic fragments were included in antimicrobial tests. In addition to the beta-defensin-like HE2beta1 with its expected antibacterial function, HE2alpha C-terminal fragments showed antibacterial activity against Escherichia coli, although it showed no significant similarity to beta-defensins nor to any other known protein family." @default.
• W2131036658 created "2016-06-24" @default.
• W2131036658 creator A5002101731 @default.
• W2131036658 creator A5035066418 @default.
• W2131036658 creator A5090719337 @default.
• W2131036658 date "2002-09-01" @default.
• W2131036658 modified "2023-09-27" @default.
• W2131036658 title "Novel Antimicrobial Peptide of Human Epididymal Duct Origin1" @default.
• W2131036658 cites W1662185404 @default.
• W2131036658 cites W1828566769 @default.
• W2131036658 cites W1969133119 @default.
• W2131036658 cites W1975085160 @default.
• W2131036658 cites W1991625690 @default.
• W2131036658 cites W1991725063 @default.
• W2131036658 cites W1999598955 @default.
• W2131036658 cites W2004805398 @default.
• W2131036658 cites W2007807255 @default.
• W2131036658 cites W2011654657 @default.
• W2131036658 cites W2022527113 @default.
• W2131036658 cites W2023604719 @default.
• W2131036658 cites W2028501275 @default.
• W2131036658 cites W2030642888 @default.
• W2131036658 cites W2038308404 @default.
• W2131036658 cites W2045777881 @default.
• W2131036658 cites W2063951978 @default.
• W2131036658 cites W2066456239 @default.
• W2131036658 cites W2081219821 @default.
• W2131036658 cites W2090042814 @default.
• W2131036658 cites W2091604858 @default.
• W2131036658 cites W2095138871 @default.
• W2131036658 cites W2102382533 @default.
• W2131036658 cites W2104159258 @default.
• W2131036658 cites W2106452753 @default.
• W2131036658 cites W2107803079 @default.
• W2131036658 cites W2117006560 @default.
• W2131036658 cites W2148067829 @default.
• W2131036658 cites W2158740347 @default.
• W2131036658 cites W2169810408 @default.
• W2131036658 cites W2394601544 @default.
• W2131036658 doi "https://doi.org/10.1095/biolreprod.102.004564" @default.
• W2131036658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12193388" @default.
• W2131036658 hasPublicationYear "2002" @default.
• W2131036658 type Work @default.
• W2131036658 sameAs 2131036658 @default.
• W2131036658 citedByCount "66" @default.
• W2131036658 countsByYear W21310366582012 @default.
• W2131036658 countsByYear W21310366582013 @default.
• W2131036658 countsByYear W21310366582014 @default.
• W2131036658 countsByYear W21310366582015 @default.
• W2131036658 countsByYear W21310366582016 @default.
• W2131036658 countsByYear W21310366582017 @default.
• W2131036658 crossrefType "journal-article" @default.
• W2131036658 hasAuthorship W2131036658A5002101731 @default.
• W2131036658 hasAuthorship W2131036658A5035066418 @default.
• W2131036658 hasAuthorship W2131036658A5090719337 @default.
• W2131036658 hasBestOaLocation W21310366581 @default.
• W2131036658 hasConcept C104317684 @default.
• W2131036658 hasConcept C129437159 @default.
• W2131036658 hasConcept C153911025 @default.
• W2131036658 hasConcept C167625842 @default.
• W2131036658 hasConcept C181199279 @default.
• W2131036658 hasConcept C2776498113 @default.
• W2131036658 hasConcept C2777265534 @default.
• W2131036658 hasConcept C2778163477 @default.
• W2131036658 hasConcept C2778824825 @default.
• W2131036658 hasConcept C2779281246 @default.
• W2131036658 hasConcept C2780072125 @default.
• W2131036658 hasConcept C2781087480 @default.
• W2131036658 hasConcept C2781254305 @default.
• W2131036658 hasConcept C40767141 @default.
• W2131036658 hasConcept C43554185 @default.
• W2131036658 hasConcept C53345823 @default.
• W2131036658 hasConcept C540938839 @default.
• W2131036658 hasConcept C54355233 @default.
• W2131036658 hasConcept C55493867 @default.
• W2131036658 hasConcept C86803240 @default.
• W2131036658 hasConceptScore W2131036658C104317684 @default.
• W2131036658 hasConceptScore W2131036658C129437159 @default.
• W2131036658 hasConceptScore W2131036658C153911025 @default.
• W2131036658 hasConceptScore W2131036658C167625842 @default.
• W2131036658 hasConceptScore W2131036658C181199279 @default.
• W2131036658 hasConceptScore W2131036658C2776498113 @default.
• W2131036658 hasConceptScore W2131036658C2777265534 @default.
• W2131036658 hasConceptScore W2131036658C2778163477 @default.
• W2131036658 hasConceptScore W2131036658C2778824825 @default.
• W2131036658 hasConceptScore W2131036658C2779281246 @default.
• W2131036658 hasConceptScore W2131036658C2780072125 @default.
• W2131036658 hasConceptScore W2131036658C2781087480 @default.
• W2131036658 hasConceptScore W2131036658C2781254305 @default.
• W2131036658 hasConceptScore W2131036658C40767141 @default.
• W2131036658 hasConceptScore W2131036658C43554185 @default.
• W2131036658 hasConceptScore W2131036658C53345823 @default.
• W2131036658 hasConceptScore W2131036658C540938839 @default.
• W2131036658 hasConceptScore W2131036658C54355233 @default.
• W2131036658 hasConceptScore W2131036658C55493867 @default.
• W2131036658 hasConceptScore W2131036658C86803240 @default.
• W2131036658 hasIssue "3" @default.
• W2131036658 hasLocation W21310366581 @default.

• next