FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135280909> ?p ?o ?g. }

• W2135280909 endingPage "508" @default.
• W2135280909 startingPage "505" @default.
• W2135280909 abstract "The majority of high-dose chemotherapy (HDC)-related complications results from bone marrow aplasia, but the graft infusion per se may cause adverse reactions due to the injection of both dimethyl sulfoxide (DMSO) and cell lysis products. We evaluated the feasibility of a two-step chemotherapy regimen with peripheral blood progenitor cell (PBPC) support in association with a novel procedure to remove DMSO and products of cell lysis from the cryopreserved cells.Stage III and IV breast cancer patients received induction chemotherapy with three cycles of CEF (cyclophosphamide 600 mg/m2, epirubicin 100 mg/m2, 5-fluorouracil 600 mg/m2) followed by three cycles of HDC consisting of escalating doses of cyclophosphamide (dose range 1200 3000 mg/m2) and carboplatin (dose range 600-1000 mg/m2), supported by DMSO-free PBPC reinfusion. DMSO was removed by a washing/enzymatic digestion procedure.Twenty patients received induction chemotherapy and eighteen completed the entire chemotherapy program; a total of fifty-four cycles of HDC were administered. Dose limiting toxicity of HDC was long-lasting grade 4 neutropenia associated with documented infection. The maximum tolerated dose (MTD) was cyclophosphamide 3000 mg/m2 and carboplatin 600 mg/m2. No side effects related to PBPC reinfusion were observed.The proposed two-step chemotherapy regimen, associated with a novel washing/enzymatic digestion procedure, is feasible in advanced breast cancer patients in the absence of complications related to the specific toxicity of PBPC reinfusion." @default.
• W2135280909 created "2016-06-24" @default.
• W2135280909 creator A5003223781 @default.
• W2135280909 creator A5020297889 @default.
• W2135280909 creator A5030852422 @default.
• W2135280909 creator A5038388365 @default.
• W2135280909 creator A5038939797 @default.
• W2135280909 creator A5041125823 @default.
• W2135280909 creator A5049770999 @default.
• W2135280909 creator A5058024552 @default.
• W2135280909 creator A5062442517 @default.
• W2135280909 creator A5068622460 @default.
• W2135280909 creator A5068715327 @default.
• W2135280909 creator A5073875192 @default.
• W2135280909 creator A5074479074 @default.
• W2135280909 creator A5090080460 @default.
• W2135280909 date "2001-04-01" @default.
• W2135280909 modified "2023-10-16" @default.
• W2135280909 title "Intensified chemotherapy supported by DMSO-free peripheral blood progenitor cells in breast cancer patients" @default.
• W2135280909 cites W1842797325 @default.
• W2135280909 cites W1973222517 @default.
• W2135280909 cites W1978978643 @default.
• W2135280909 cites W1979212149 @default.
• W2135280909 cites W2067262398 @default.
• W2135280909 cites W2075770009 @default.
• W2135280909 cites W2094454423 @default.
• W2135280909 cites W2095275141 @default.
• W2135280909 cites W2095592066 @default.
• W2135280909 cites W37658540 @default.
• W2135280909 doi "https://doi.org/10.1023/a:1011123218220" @default.
• W2135280909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11398884" @default.
• W2135280909 hasPublicationYear "2001" @default.
• W2135280909 type Work @default.
• W2135280909 sameAs 2135280909 @default.
• W2135280909 citedByCount "14" @default.
• W2135280909 countsByYear W21352809092012 @default.
• W2135280909 countsByYear W21352809092013 @default.
• W2135280909 countsByYear W21352809092014 @default.
• W2135280909 crossrefType "journal-article" @default.
• W2135280909 hasAuthorship W2135280909A5003223781 @default.
• W2135280909 hasAuthorship W2135280909A5020297889 @default.
• W2135280909 hasAuthorship W2135280909A5030852422 @default.
• W2135280909 hasAuthorship W2135280909A5038388365 @default.
• W2135280909 hasAuthorship W2135280909A5038939797 @default.
• W2135280909 hasAuthorship W2135280909A5041125823 @default.
• W2135280909 hasAuthorship W2135280909A5049770999 @default.
• W2135280909 hasAuthorship W2135280909A5058024552 @default.
• W2135280909 hasAuthorship W2135280909A5062442517 @default.
• W2135280909 hasAuthorship W2135280909A5068622460 @default.
• W2135280909 hasAuthorship W2135280909A5068715327 @default.
• W2135280909 hasAuthorship W2135280909A5073875192 @default.
• W2135280909 hasAuthorship W2135280909A5074479074 @default.
• W2135280909 hasAuthorship W2135280909A5090080460 @default.
• W2135280909 hasBestOaLocation W21352809091 @default.
• W2135280909 hasConcept C121608353 @default.
• W2135280909 hasConcept C126322002 @default.
• W2135280909 hasConcept C126894567 @default.
• W2135280909 hasConcept C141071460 @default.
• W2135280909 hasConcept C2776694085 @default.
• W2135280909 hasConcept C2776755627 @default.
• W2135280909 hasConcept C2777063308 @default.
• W2135280909 hasConcept C2778239845 @default.
• W2135280909 hasConcept C2779968505 @default.
• W2135280909 hasConcept C2780835546 @default.
• W2135280909 hasConcept C2781413609 @default.
• W2135280909 hasConcept C2781451048 @default.
• W2135280909 hasConcept C29730261 @default.
• W2135280909 hasConcept C530470458 @default.
• W2135280909 hasConcept C71924100 @default.
• W2135280909 hasConcept C90924648 @default.
• W2135280909 hasConceptScore W2135280909C121608353 @default.
• W2135280909 hasConceptScore W2135280909C126322002 @default.
• W2135280909 hasConceptScore W2135280909C126894567 @default.
• W2135280909 hasConceptScore W2135280909C141071460 @default.
• W2135280909 hasConceptScore W2135280909C2776694085 @default.
• W2135280909 hasConceptScore W2135280909C2776755627 @default.
• W2135280909 hasConceptScore W2135280909C2777063308 @default.
• W2135280909 hasConceptScore W2135280909C2778239845 @default.
• W2135280909 hasConceptScore W2135280909C2779968505 @default.
• W2135280909 hasConceptScore W2135280909C2780835546 @default.
• W2135280909 hasConceptScore W2135280909C2781413609 @default.
• W2135280909 hasConceptScore W2135280909C2781451048 @default.
• W2135280909 hasConceptScore W2135280909C29730261 @default.
• W2135280909 hasConceptScore W2135280909C530470458 @default.
• W2135280909 hasConceptScore W2135280909C71924100 @default.
• W2135280909 hasConceptScore W2135280909C90924648 @default.
• W2135280909 hasIssue "4" @default.
• W2135280909 hasLocation W21352809091 @default.
• W2135280909 hasLocation W21352809092 @default.
• W2135280909 hasOpenAccess W2135280909 @default.
• W2135280909 hasPrimaryLocation W21352809091 @default.
• W2135280909 hasRelatedWork W2000611656 @default.
• W2135280909 hasRelatedWork W2046154062 @default.
• W2135280909 hasRelatedWork W2108334876 @default.
• W2135280909 hasRelatedWork W2189079197 @default.
• W2135280909 hasRelatedWork W2320162970 @default.
• W2135280909 hasRelatedWork W2327014840 @default.
• W2135280909 hasRelatedWork W2358269044 @default.

• next