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• W2135320413 startingPage "1071" @default.
• W2135320413 abstract "Equine recurrent airway obstruction (RAO) has been used as a naturally occurring model of human asthma. However, it is unknown whether there is an early-phase response in RAO. The aim of this study was to determine whether exposure to organic dust induces immediate changes in lung function in RAO-affected horses, which could be mediated by airway mast cells. Six RAO-affected horses in remission and six control horses were challenged with hay-straw dust suspension by nebulization. Total respiratory resistance at 1 Hz, measured by forced oscillation, was increased from 0.62 ± 0.09 cmH 2 O·l −1 ·s (mean ± SE) to 1.23 ± 0.20 cmH 2 O·l −1 ·s 15 min after nebulization in control horses ( P = 0.023) but did not change significantly in the RAO group. Total respiratory reactance at 1 Hz ( P = 0.005) was significantly lower in the control horses (−0.77 ± 0.07 cmH 2 O·l −1 ·s) than in the RAO group (−0.49 ± 0.04 cmH 2 O·l −1 ·s) 15 min after nebulization. Bronchoalveolar lavage fluid (BALF) histamine concentration was significantly elevated 10 and 20 min postnebulization in control horses but not in RAO horses. Minimum reactance at 1 Hz in the early postnebulization period significantly correlated with both prechallenge BALF mast cell numbers ( r = −0.65, P = 0.02) and peak BALF histamine concentration postnebulization ( r = −0.61, P = 0.04). In conclusion, RAO horses, unlike human asthmatic patients, do not exhibit an early-phase response. However, healthy control horses do demonstrate a mild but significant early (<20 min) phase response to inhaled organic dust. This response may serve to decrease the subsequent dose of dust inhaled and as such provide a protective mechanism, which may be compromised in RAO horses." @default.
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• W2135320413 date "2007-03-01" @default.
• W2135320413 modified "2023-10-16" @default.
• W2135320413 title "Early onset airway obstruction in response to organic dust in the horse" @default.
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• W2135320413 doi "https://doi.org/10.1152/japplphysiol.00264.2006" @default.
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