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• W2135656329 endingPage "374" @default.
• W2135656329 startingPage "368" @default.
• W2135656329 abstract "Abstract Viral infections are important causes of morbidity and mortality for patients with a hematological malignancy. However, the true incidence and consequences of viral infections for these patients who undergo conventional nontransplant therapy are poorly defined. The difference in incidence and outcome of viral infections among patient groups is wide, but dependent upon the intensity and duration of T-cell–mediated immune suppression. Infections caused by cytomegalovirus (CMV), herpes simplex virus (HSV), varicella-zoster virus (VZV), respiratory syncytial virus (RSV), parainfluenza viruses and influenza viruses have been intensely studied, yet newly recognized aspects of these viral infections including late CMV infection; the emergence of new viral pathogens (human herpesvirus-6, BK virus, adenovirus, and human metapneumovirus); the development of molecular diagnostic techniques, and the potential of new agents for viral prophylaxis (maribavir), or preemptive therapy (valganciclovir) form the basis of this review. Well-designed prospective studies are needed to better clarify the spectrum of these viral infections and develop effective prevention and treatment strategies. Yet the increased use of agents like alemtuzumab that induce profound T-cell depletion demands that we develop a better understanding of viral infections that occur in patients with hematological malignancy who receive nontransplant therapy." @default.
• W2135656329 created "2016-06-24" @default.
• W2135656329 creator A5002060200 @default.
• W2135656329 date "2006-01-01" @default.
• W2135656329 modified "2023-10-02" @default.
• W2135656329 title "Viral Infections in Patients with Hematological Malignancies" @default.
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• W2135656329 doi "https://doi.org/10.1182/asheducation-2006.1.368" @default.
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