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• W2138429544 endingPage "045003" @default.
• W2138429544 startingPage "045003" @default.
• W2138429544 abstract "In order to improve the mechanical properties of poly(L-lactide) (PLLA) based implants, a study was made of how far well dispersed multi-walled carbon nanotubes (MWCNTs) within a PLLA matrix were able to positively affect these properties. To this end, pyrene-end-functionalized poly(L-lactide) (py-end-PLLA) was evaluated as a dispersing agent. Transmission electron microscopy (TEM) analyses and mechanical tests of MWCNTs-based materials demonstrated an enhancement of MWCNT dispersion in the PLLA matrix and improved Young's modulus (E) when 4 wt% of py-end-PLLA was used as the dispersing agent. Subsequently, the bioacceptance of PLLA/py-end-PLLA/MWCNTs nanocomposites was evaluated using human bone marrow stromal cells (HBMC) in vitro. The inclusion of py-end-PLLA and MWCNTs supported HBMC adhesion and proliferation. The expression levels of the bone-specific markers indicated that the cells kept their potential to undergo osteogenic differentiation. The results of this study indicate that the addition of MWCNT combined with py-end-PLLA in PLLA/py-end-PLLA/MWCNTs nanocomposites may widen the range of applications of PLLA within the field of bone tissue engineering thanks to their mechanical strength and cytocompatibility." @default.
• W2138429544 created "2016-06-24" @default.
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• W2138429544 date "2015-07-08" @default.
• W2138429544 modified "2023-09-23" @default.
• W2138429544 title "Pyrene-end-functionalized poly(L-lactide) as an efficient carbon nanotube dispersing agent in poly(L-lactide): mechanical performance and biocompatibility study" @default.
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• W2138429544 doi "https://doi.org/10.1088/1748-6041/10/4/045003" @default.
• W2138429544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26154591" @default.
• W2138429544 hasPublicationYear "2015" @default.
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