FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141263669> ?p ?o ?g. }

• W2141263669 endingPage "2680" @default.
• W2141263669 startingPage "2673" @default.
• W2141263669 abstract "Styrene-specific N-7- and O6guanine DNA adducts and N-terminal valine adducts were determined in mice tissues after the intraperitoneal administration of styrene. Blood, liver, lungs and spleen were collected 3 h after administration of various doses (from 0 to 435 mmol/kg b.w.) of styrene. DNA adducts were analysed by the modified 32P-postlabelling assay and N-terminal valine adducts were detected by GC-MS according to the modified Edman degradation technique. In the dose-range studied, for all adducts a clear dose-response relationship was observed. 7-Alkylguanines and O6-styrene guanine adducts were most abundant in lungs, ∼30% more than in liver and spleen. In all analysed tissues 7-alkylguanines were more abundant than O6-styrene guanine adducts. We found a considerably lower rate of N-terminal valine adduct formation as compared with both DNA adducts. The ratio between 7-alkylguanines and O6-guanine adducts was 1.9, 1.6 and 7.8 in liver, lung and spleen, respectively. In vitro determination of both DNA adducts by 32P-postlabelling resulted also in a lower ratio than that reported earlier using an HPLC analysis. All correlation's between dose, haemoglobin and DNA adducts were very high and significant. However, at the highest injected doses the adduct formation showed a levelling off. To explain this phenomenon a model simulation was performed revealing that 3 h after the injection of the higher doses styrene was not completely converted into styrene-7, 8-oxide." @default.
• W2141263669 created "2016-06-24" @default.
• W2141263669 creator A5005497955 @default.
• W2141263669 creator A5042637685 @default.
• W2141263669 creator A5061569349 @default.
• W2141263669 creator A5066454098 @default.
• W2141263669 creator A5067501798 @default.
• W2141263669 creator A5090212645 @default.
• W2141263669 date "1996-01-01" @default.
• W2141263669 modified "2023-10-01" @default.
• W2141263669 title "Adduct formation on DNA and haemoglobin in mice intraperitoneally administered with styrene" @default.
• W2141263669 cites W1892194801 @default.
• W2141263669 cites W1966670484 @default.
• W2141263669 cites W1967912888 @default.
• W2141263669 cites W1967949073 @default.
• W2141263669 cites W1984340200 @default.
• W2141263669 cites W1988141759 @default.
• W2141263669 cites W1989991377 @default.
• W2141263669 cites W2001284911 @default.
• W2141263669 cites W2002976054 @default.
• W2141263669 cites W2009341396 @default.
• W2141263669 cites W2012499156 @default.
• W2141263669 cites W2023927250 @default.
• W2141263669 cites W2024160652 @default.
• W2141263669 cites W2032646339 @default.
• W2141263669 cites W2032724989 @default.
• W2141263669 cites W2035600130 @default.
• W2141263669 cites W2038591611 @default.
• W2141263669 cites W2055261699 @default.
• W2141263669 cites W2063134544 @default.
• W2141263669 cites W2105015778 @default.
• W2141263669 cites W2127886412 @default.
• W2141263669 cites W2137615900 @default.
• W2141263669 cites W2149213081 @default.
• W2141263669 cites W2157037235 @default.
• W2141263669 cites W2164993234 @default.
• W2141263669 doi "https://doi.org/10.1093/carcin/17.12.2673" @default.
• W2141263669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9006105" @default.
• W2141263669 hasPublicationYear "1996" @default.
• W2141263669 type Work @default.
• W2141263669 sameAs 2141263669 @default.
• W2141263669 citedByCount "56" @default.
• W2141263669 countsByYear W21412636692012 @default.
• W2141263669 countsByYear W21412636692013 @default.
• W2141263669 countsByYear W21412636692014 @default.
• W2141263669 countsByYear W21412636692016 @default.
• W2141263669 countsByYear W21412636692019 @default.
• W2141263669 countsByYear W21412636692023 @default.
• W2141263669 crossrefType "journal-article" @default.
• W2141263669 hasAuthorship W2141263669A5005497955 @default.
• W2141263669 hasAuthorship W2141263669A5042637685 @default.
• W2141263669 hasAuthorship W2141263669A5061569349 @default.
• W2141263669 hasAuthorship W2141263669A5066454098 @default.
• W2141263669 hasAuthorship W2141263669A5067501798 @default.
• W2141263669 hasAuthorship W2141263669A5090212645 @default.
• W2141263669 hasBestOaLocation W21412636691 @default.
• W2141263669 hasConcept C104317684 @default.
• W2141263669 hasConcept C108204754 @default.
• W2141263669 hasConcept C153911025 @default.
• W2141263669 hasConcept C15920480 @default.
• W2141263669 hasConcept C178790620 @default.
• W2141263669 hasConcept C185592680 @default.
• W2141263669 hasConcept C203014093 @default.
• W2141263669 hasConcept C2776186722 @default.
• W2141263669 hasConcept C2777566558 @default.
• W2141263669 hasConcept C2777573094 @default.
• W2141263669 hasConcept C2778301229 @default.
• W2141263669 hasConcept C2780931953 @default.
• W2141263669 hasConcept C512185932 @default.
• W2141263669 hasConcept C515207424 @default.
• W2141263669 hasConcept C521977710 @default.
• W2141263669 hasConcept C552990157 @default.
• W2141263669 hasConcept C55493867 @default.
• W2141263669 hasConcept C86803240 @default.
• W2141263669 hasConceptScore W2141263669C104317684 @default.
• W2141263669 hasConceptScore W2141263669C108204754 @default.
• W2141263669 hasConceptScore W2141263669C153911025 @default.
• W2141263669 hasConceptScore W2141263669C15920480 @default.
• W2141263669 hasConceptScore W2141263669C178790620 @default.
• W2141263669 hasConceptScore W2141263669C185592680 @default.
• W2141263669 hasConceptScore W2141263669C203014093 @default.
• W2141263669 hasConceptScore W2141263669C2776186722 @default.
• W2141263669 hasConceptScore W2141263669C2777566558 @default.
• W2141263669 hasConceptScore W2141263669C2777573094 @default.
• W2141263669 hasConceptScore W2141263669C2778301229 @default.
• W2141263669 hasConceptScore W2141263669C2780931953 @default.
• W2141263669 hasConceptScore W2141263669C512185932 @default.
• W2141263669 hasConceptScore W2141263669C515207424 @default.
• W2141263669 hasConceptScore W2141263669C521977710 @default.
• W2141263669 hasConceptScore W2141263669C552990157 @default.
• W2141263669 hasConceptScore W2141263669C55493867 @default.
• W2141263669 hasConceptScore W2141263669C86803240 @default.
• W2141263669 hasIssue "12" @default.
• W2141263669 hasLocation W21412636691 @default.
• W2141263669 hasLocation W21412636692 @default.
• W2141263669 hasOpenAccess W2141263669 @default.
• W2141263669 hasPrimaryLocation W21412636691 @default.
• W2141263669 hasRelatedWork W1988141759 @default.

• next