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• W2141565645 abstract "Naturally occurring regulatory T cells (T reg cells) are a thymus-derived subset of T cells, which are crucial for the maintenance of peripheral tolerance by controlling potentially autoreactive T cells. However, the underlying molecular mechanisms of this strictly cell contact–dependent process are still elusive. Here we show that naturally occurring T reg cells harbor high levels of cyclic adenosine monophosphate (cAMP). This second messenger is known to be a potent inhibitor of proliferation and interleukin 2 synthesis in T cells. Upon coactivation with naturally occurring T reg cells the cAMP content of responder T cells is also strongly increased. Furthermore, we demonstrate that naturally occurring T reg cells and conventional T cells communicate via cell contact–dependent gap junction formation. The suppressive activity of naturally occurring T reg cells is abolished by a cAMP antagonist as well as by a gap junction inhibitor, which blocks the cell contact–dependent transfer of cAMP to responder T cells. Accordingly, our results suggest that cAMP is crucial for naturally occurring T reg cell–mediated suppression and traverses membranes via gap junctions. Hence, naturally occurring T reg cells unexpectedly may control the immune regulatory network by a well-known mechanism based on the intercellular transport of cAMP via gap junctions." @default.
• W2141565645 created "2016-06-24" @default.
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• W2141565645 date "2007-05-14" @default.
• W2141565645 modified "2023-09-30" @default.
• W2141565645 title "Cyclic adenosine monophosphate is a key component of regulatory T cell–mediated suppression" @default.
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• W2141565645 doi "https://doi.org/10.1084/jem.20062129" @default.
• W2141565645 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2118605" @default.
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• W2141565645 hasPublicationYear "2007" @default.
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