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• W2142371158 endingPage "3034" @default.
• W2142371158 startingPage "3030" @default.
• W2142371158 abstract "Abstract Protein tyrosine phosphatase (PTP) ε (PTPε) exists as 2 forms generated by alternative promoter usage. It has recently been reported that a cytosolic isoform of PTPε (PTPεC) when over-expressed in murine M1 myeloid cells inhibits interleukin-6 (IL-6)– and leukemia inhibitory factor–induced activation of Janus kinsases (JAKs), thereby suppressing STAT3 tyrosine phosphorylation and STAT3 signaling. This study characterizes an inhibitory action of PTPεC on IL-6 signaling and also reveals that PTPεC inhibitory activity is independent of other potential negative regulators, such as SHP-2 and SOCS family proteins. Furthermore, it analyzes the selectivity of PTPεC action toward several cytokines. On IL-6 stimulation, expression of PTPεC-DA, a catalytically inactive mutant of PTPεC, results in an earlier onset of STAT3 tyrosine phosphorylation, suggesting different modes of action between PTPεC and other negative regulators. In addition, the study shows PTPεC-DA enhances activation of STAT1 by IL-6 as well. In terms of specificity to cytokines, over-expressed PTPεC also inhibits IL-10–induced tyrosine phosphorylation of STAT3 in M1 cells, whereas PTPεC does not affect either interferon-β– and interferon-γ–induced tyrosine phosphorylation of STATs or expression of STAT transcriptional targets. Among cytokines tested, the inhibitory effect of PTPεC is selective to IL-6– and IL-10–induced JAK-STAT signaling." @default.
• W2142371158 created "2016-06-24" @default.
• W2142371158 creator A5013218910 @default.
• W2142371158 creator A5058407542 @default.
• W2142371158 creator A5076119421 @default.
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• W2142371158 date "2001-11-15" @default.
• W2142371158 modified "2023-10-03" @default.
• W2142371158 title "Protein tyrosine phosphatase εC selectively inhibits interleukin-6– and interleukin- 10–induced JAK-STAT signaling" @default.
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• W2142371158 doi "https://doi.org/10.1182/blood.v98.10.3030" @default.
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