FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142823193> ?p ?o ?g. }

• W2142823193 endingPage "488.e2" @default.
• W2142823193 startingPage "483" @default.
• W2142823193 abstract "ObjectiveApproximately 10% of patients undergoing cardiac surgery have perioperative myocardial injury. A recent genome-wide association study identified an association between myocardial infarction in nonsurgical populations and common genetic variants on chromosome 9p21. We hypothesized that these variants are also associated with perioperative myocardial injury after isolated primary coronary artery bypass graft surgery.MethodsIn a prospective observational study of 846 Caucasian patients undergoing primary coronary bypass surgery at 2 US centers, we genotyped 61 linkage-disequilibrium tagging single nucleotide polymorphisms, encompassing 436 kbp of the 9p21 region. A multivariable logistic model was used to adjust for previously identified clinical covariates of perioperative myocardial injury. Perioperative myocardial injury was defined as a postoperative day 1 cardiac troponin I in the top 10th percentile (>9.13 μg/L) of the cohort. Multiple testing of single nucleotide polymorphisms was corrected for with family-wise errors.ResultsPrior myocardial infarction and longer cardiopulmonary bypass time were significant independent predictors of perioperative myocardial injury. Levels of postoperative cardiac troponin I were incrementally increased for each additional copy of the risk alleles of 3 single nucleotide polymorphisms: rs10116277, rs6475606, and rs2383207. Adjusted additive odds ratios ranged between 1.64 and 1.79 (asymptotic P value between 3.7 × 10−3 and 6 × 10−4) and remained significantly associated with perioperative myocardial injury even after accounting for clinical covariates including severity of coronary disease, and multiple comparisons.ConclusionsWe have now demonstrated that common genetic variants in the same 9p21 locus, previously known to be associated with myocardial infarction in nonsurgical populations, are also associated with perioperative myocardial injury after coronary artery bypass grafting. Further investigation is warranted to elucidate functional mechanisms. Approximately 10% of patients undergoing cardiac surgery have perioperative myocardial injury. A recent genome-wide association study identified an association between myocardial infarction in nonsurgical populations and common genetic variants on chromosome 9p21. We hypothesized that these variants are also associated with perioperative myocardial injury after isolated primary coronary artery bypass graft surgery. In a prospective observational study of 846 Caucasian patients undergoing primary coronary bypass surgery at 2 US centers, we genotyped 61 linkage-disequilibrium tagging single nucleotide polymorphisms, encompassing 436 kbp of the 9p21 region. A multivariable logistic model was used to adjust for previously identified clinical covariates of perioperative myocardial injury. Perioperative myocardial injury was defined as a postoperative day 1 cardiac troponin I in the top 10th percentile (>9.13 μg/L) of the cohort. Multiple testing of single nucleotide polymorphisms was corrected for with family-wise errors. Prior myocardial infarction and longer cardiopulmonary bypass time were significant independent predictors of perioperative myocardial injury. Levels of postoperative cardiac troponin I were incrementally increased for each additional copy of the risk alleles of 3 single nucleotide polymorphisms: rs10116277, rs6475606, and rs2383207. Adjusted additive odds ratios ranged between 1.64 and 1.79 (asymptotic P value between 3.7 × 10−3 and 6 × 10−4) and remained significantly associated with perioperative myocardial injury even after accounting for clinical covariates including severity of coronary disease, and multiple comparisons. We have now demonstrated that common genetic variants in the same 9p21 locus, previously known to be associated with myocardial infarction in nonsurgical populations, are also associated with perioperative myocardial injury after coronary artery bypass grafting. Further investigation is warranted to elucidate functional mechanisms." @default.
• W2142823193 created "2016-06-24" @default.
• W2142823193 creator A5003221869 @default.
• W2142823193 creator A5011778868 @default.
• W2142823193 creator A5021979803 @default.
• W2142823193 creator A5045246740 @default.
• W2142823193 creator A5046535273 @default.
• W2142823193 creator A5063843642 @default.
• W2142823193 creator A5088899338 @default.
• W2142823193 date "2010-02-01" @default.
• W2142823193 modified "2023-09-26" @default.
• W2142823193 title "Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery" @default.
• W2142823193 cites W1499959019 @default.
• W2142823193 cites W1966968530 @default.
• W2142823193 cites W1981168111 @default.
• W2142823193 cites W2019621794 @default.
• W2142823193 cites W2021458704 @default.
• W2142823193 cites W2036198235 @default.
• W2142823193 cites W2042207708 @default.
• W2142823193 cites W2042581571 @default.
• W2142823193 cites W2048755332 @default.
• W2142823193 cites W2065010189 @default.
• W2142823193 cites W2065891752 @default.
• W2142823193 cites W2100812189 @default.
• W2142823193 cites W2120451046 @default.
• W2142823193 cites W2124191974 @default.
• W2142823193 cites W2134368004 @default.
• W2142823193 cites W2134783591 @default.
• W2142823193 cites W2144062486 @default.
• W2142823193 cites W2155121555 @default.
• W2142823193 cites W2162530578 @default.
• W2142823193 cites W2162669740 @default.
• W2142823193 cites W2166512409 @default.
• W2142823193 cites W2167521765 @default.
• W2142823193 cites W2171205956 @default.
• W2142823193 cites W2973596107 @default.
• W2142823193 cites W36880162 @default.
• W2142823193 doi "https://doi.org/10.1016/j.jtcvs.2009.06.032" @default.
• W2142823193 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2813396" @default.
• W2142823193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19819472" @default.
• W2142823193 hasPublicationYear "2010" @default.
• W2142823193 type Work @default.
• W2142823193 sameAs 2142823193 @default.
• W2142823193 citedByCount "20" @default.
• W2142823193 countsByYear W21428231932012 @default.
• W2142823193 countsByYear W21428231932013 @default.
• W2142823193 countsByYear W21428231932014 @default.
• W2142823193 countsByYear W21428231932015 @default.
• W2142823193 countsByYear W21428231932016 @default.
• W2142823193 countsByYear W21428231932017 @default.
• W2142823193 countsByYear W21428231932018 @default.
• W2142823193 countsByYear W21428231932019 @default.
• W2142823193 countsByYear W21428231932021 @default.
• W2142823193 crossrefType "journal-article" @default.
• W2142823193 hasAuthorship W2142823193A5003221869 @default.
• W2142823193 hasAuthorship W2142823193A5011778868 @default.
• W2142823193 hasAuthorship W2142823193A5021979803 @default.
• W2142823193 hasAuthorship W2142823193A5045246740 @default.
• W2142823193 hasAuthorship W2142823193A5046535273 @default.
• W2142823193 hasAuthorship W2142823193A5063843642 @default.
• W2142823193 hasAuthorship W2142823193A5088899338 @default.
• W2142823193 hasBestOaLocation W21428231931 @default.
• W2142823193 hasConcept C104317684 @default.
• W2142823193 hasConcept C115725540 @default.
• W2142823193 hasConcept C126322002 @default.
• W2142823193 hasConcept C135763542 @default.
• W2142823193 hasConcept C141071460 @default.
• W2142823193 hasConcept C153209595 @default.
• W2142823193 hasConcept C156957248 @default.
• W2142823193 hasConcept C164705383 @default.
• W2142823193 hasConcept C2775901492 @default.
• W2142823193 hasConcept C2776820930 @default.
• W2142823193 hasConcept C2778213512 @default.
• W2142823193 hasConcept C2778789114 @default.
• W2142823193 hasConcept C2779433084 @default.
• W2142823193 hasConcept C31174226 @default.
• W2142823193 hasConcept C36036425 @default.
• W2142823193 hasConcept C500558357 @default.
• W2142823193 hasConcept C54355233 @default.
• W2142823193 hasConcept C71924100 @default.
• W2142823193 hasConcept C86803240 @default.
• W2142823193 hasConceptScore W2142823193C104317684 @default.
• W2142823193 hasConceptScore W2142823193C115725540 @default.
• W2142823193 hasConceptScore W2142823193C126322002 @default.
• W2142823193 hasConceptScore W2142823193C135763542 @default.
• W2142823193 hasConceptScore W2142823193C141071460 @default.
• W2142823193 hasConceptScore W2142823193C153209595 @default.
• W2142823193 hasConceptScore W2142823193C156957248 @default.
• W2142823193 hasConceptScore W2142823193C164705383 @default.
• W2142823193 hasConceptScore W2142823193C2775901492 @default.
• W2142823193 hasConceptScore W2142823193C2776820930 @default.
• W2142823193 hasConceptScore W2142823193C2778213512 @default.
• W2142823193 hasConceptScore W2142823193C2778789114 @default.
• W2142823193 hasConceptScore W2142823193C2779433084 @default.
• W2142823193 hasConceptScore W2142823193C31174226 @default.
• W2142823193 hasConceptScore W2142823193C36036425 @default.
• W2142823193 hasConceptScore W2142823193C500558357 @default.
• W2142823193 hasConceptScore W2142823193C54355233 @default.

• next