FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143663670> ?p ?o ?g. }

• W2143663670 endingPage "1777" @default.
• W2143663670 startingPage "1772" @default.
• W2143663670 abstract "The rate of clinical progression is variable among individuals infected with human immunodeficiency virus type 1 (HIV-1). Changes in viral burden which correlate with disease status have been demonstrated in cross-sectional studies; however, a detailed longitudinal study of the temporal relationship between viral burden, CD4+ T-cell numbers, and clinical status throughout the course of infection has not been reported. Multiple longitudinal blood samples were obtained from four HIV-1-infected individuals with clinically divergent profiles. Levels of HIV-1 were measured in sequential samples of peripheral blood mononuclear cells, using both end-point dilution cultures and quantitative polymerase chain reaction methods. Serial HIV-1 isolates from each case were also evaluated to determine their biological properties in vitro. For the three patients with clinical progression, a dramatic increase in the level of HIV-1 was observed concurrent with or prior to a marked drop in CD4+ T lymphocytes. This increase in viral burden was temporally associated with the emergence of a more cytopathic viral phenotype. In contrast, consistently low levels of HIV-1 were observed in the one patient who was clinically and immunologically stable for more than a decade. Moreover, viral isolates from this patient were less cytopathic in vitro compared with HIV-1 isolates from those patients with disease progression. The temporal association between increased viral burden and CD4+ T-cell decline suggests a direct role for HIV-1 in the cytopathology of CD4+ T cells in vivo. Our results indicate that the pathogenic mechanisms responsible for CD4+ T-cell depletion may be related to both quantitative and qualitative changes in HIV-1." @default.
• W2143663670 created "2016-06-24" @default.
• W2143663670 creator A5005110163 @default.
• W2143663670 creator A5020311779 @default.
• W2143663670 creator A5028738742 @default.
• W2143663670 creator A5081732015 @default.
• W2143663670 date "1993-04-01" @default.
• W2143663670 modified "2023-10-12" @default.
• W2143663670 title "Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals" @default.
• W2143663670 cites W1487932987 @default.
• W2143663670 cites W1593510994 @default.
• W2143663670 cites W1723922714 @default.
• W2143663670 cites W1739595091 @default.
• W2143663670 cites W1972872628 @default.
• W2143663670 cites W1980259340 @default.
• W2143663670 cites W1990273009 @default.
• W2143663670 cites W1991670386 @default.
• W2143663670 cites W1993591984 @default.
• W2143663670 cites W2010546503 @default.
• W2143663670 cites W2015326137 @default.
• W2143663670 cites W2032118018 @default.
• W2143663670 cites W2046965609 @default.
• W2143663670 cites W2048499136 @default.
• W2143663670 cites W2065114401 @default.
• W2143663670 cites W2085721436 @default.
• W2143663670 cites W2086369756 @default.
• W2143663670 cites W2093122125 @default.
• W2143663670 cites W2114279162 @default.
• W2143663670 cites W2142809896 @default.
• W2143663670 cites W2142997299 @default.
• W2143663670 cites W2155365882 @default.
• W2143663670 cites W2157644226 @default.
• W2143663670 cites W2162772698 @default.
• W2143663670 cites W2318770038 @default.
• W2143663670 cites W2323021547 @default.
• W2143663670 cites W3144051925 @default.
• W2143663670 doi "https://doi.org/10.1128/jvi.67.4.1772-1777.1993" @default.
• W2143663670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/240220" @default.
• W2143663670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8095306" @default.
• W2143663670 hasPublicationYear "1993" @default.
• W2143663670 type Work @default.
• W2143663670 sameAs 2143663670 @default.
• W2143663670 citedByCount "446" @default.
• W2143663670 countsByYear W21436636702012 @default.
• W2143663670 countsByYear W21436636702013 @default.
• W2143663670 countsByYear W21436636702014 @default.
• W2143663670 countsByYear W21436636702016 @default.
• W2143663670 countsByYear W21436636702017 @default.
• W2143663670 countsByYear W21436636702018 @default.
• W2143663670 countsByYear W21436636702019 @default.
• W2143663670 countsByYear W21436636702020 @default.
• W2143663670 countsByYear W21436636702021 @default.
• W2143663670 countsByYear W21436636702022 @default.
• W2143663670 countsByYear W21436636702023 @default.
• W2143663670 crossrefType "journal-article" @default.
• W2143663670 hasAuthorship W2143663670A5005110163 @default.
• W2143663670 hasAuthorship W2143663670A5020311779 @default.
• W2143663670 hasAuthorship W2143663670A5028738742 @default.
• W2143663670 hasAuthorship W2143663670A5081732015 @default.
• W2143663670 hasBestOaLocation W21436636701 @default.
• W2143663670 hasConcept C137061746 @default.
• W2143663670 hasConcept C142462285 @default.
• W2143663670 hasConcept C159047783 @default.
• W2143663670 hasConcept C202751555 @default.
• W2143663670 hasConcept C203014093 @default.
• W2143663670 hasConcept C2522874641 @default.
• W2143663670 hasConcept C2777761686 @default.
• W2143663670 hasConcept C2779690655 @default.
• W2143663670 hasConcept C2780727368 @default.
• W2143663670 hasConcept C54355233 @default.
• W2143663670 hasConcept C86803240 @default.
• W2143663670 hasConceptScore W2143663670C137061746 @default.
• W2143663670 hasConceptScore W2143663670C142462285 @default.
• W2143663670 hasConceptScore W2143663670C159047783 @default.
• W2143663670 hasConceptScore W2143663670C202751555 @default.
• W2143663670 hasConceptScore W2143663670C203014093 @default.
• W2143663670 hasConceptScore W2143663670C2522874641 @default.
• W2143663670 hasConceptScore W2143663670C2777761686 @default.
• W2143663670 hasConceptScore W2143663670C2779690655 @default.
• W2143663670 hasConceptScore W2143663670C2780727368 @default.
• W2143663670 hasConceptScore W2143663670C54355233 @default.
• W2143663670 hasConceptScore W2143663670C86803240 @default.
• W2143663670 hasIssue "4" @default.
• W2143663670 hasLocation W21436636701 @default.
• W2143663670 hasLocation W21436636702 @default.
• W2143663670 hasLocation W21436636703 @default.
• W2143663670 hasLocation W21436636704 @default.
• W2143663670 hasOpenAccess W2143663670 @default.
• W2143663670 hasPrimaryLocation W21436636701 @default.
• W2143663670 hasRelatedWork W1660207082 @default.
• W2143663670 hasRelatedWork W1976124441 @default.
• W2143663670 hasRelatedWork W2009558996 @default.
• W2143663670 hasRelatedWork W2016082374 @default.
• W2143663670 hasRelatedWork W2056473717 @default.
• W2143663670 hasRelatedWork W2057744966 @default.
• W2143663670 hasRelatedWork W2077563405 @default.
• W2143663670 hasRelatedWork W2103264367 @default.
• W2143663670 hasRelatedWork W2155048514 @default.

• next