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• W2146379271 startingPage "1041" @default.
• W2146379271 abstract "Abstract Fasting stimulates corticosterone (B) secretion and the expression and secretion of hypothalamic neuropeptide Y in rats. These studies tested the hypothesis that the rapid and marked fasting-induced increases in plasma B are responsible for stimulation of neuropeptide Y (NPY) gene expression. Plasma leptin and insulin were measured because they are also signals known to affect NPY messenger RNA (mRNA). Intact or adrenalectomized rats given a low fixed level of corticosterone (B replaced) were fasted for 48 h. NPY mRNA in the mediobasal hypothalamus, measured by nuclease protection assay, was elevated similarly above ad lib-fed controls in both intact and B replaced groups at 15 and 48 h after the onset of fasting. NPY immunoreactivity in the mediobasal hypothalamus increased between 3 and 48 h after onset of the fast in intact but not in B replaced groups. The fasting-induced decreases in leptin observed in intact rats at 48 h did not occur in B replaced rats. Fasting-induced decreases in insulin occurred in B replaced rats but not in intact rats. We conclude that: 1) elevated B is not required for fasting-induced increases in hypothalamic NPY gene expression; and 2) decreases in neither leptin nor insulin alone signal the changes that occur in NPY mRNA in fasted rats." @default.
• W2146379271 created "2016-06-24" @default.
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• W2146379271 date "1997-03-01" @default.
• W2146379271 modified "2023-10-03" @default.
• W2146379271 title "Elevated Corticosterone Is Not Required for the Rapid Induction of Neuropeptide Y Gene Expression by an Overnight Fast*" @default.
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• W2146379271 doi "https://doi.org/10.1210/endo.138.3.4995" @default.
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