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- W2149133071 abstract "Abstract 5β, 7α-Dihydroxy-11-ketotetranor-prostanoic acid was the major metabolite excreted in the urine of guinea pigs injected with tritium-labeled prostaglandin E1, prostaglandin E2, 11α,15l-dihydroxy-9-ketoprost-5-enoic acid, 11α-hydroxy-9,15-diketoprostanoic acid, and 11α-hydroxy-9,15-diketoprost-5-enoic acid. A method was developed for quantitative determination of 5β,7α-dihydroxy-11-ketotetranor-prostanoic acid in 24-hour samples of guinea pig urine. The basal excretion of the metabolite in 10 male guinea pigs was 1.34 to 2.74 µg per kg of body weight x 24 hours. Administration of 50 mg of indomethacin per day inhibited the excretion of the urinary metabolite by about 98%." @default.
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- W2149133071 date "1972-06-01" @default.
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- W2149133071 title "On the Metabolism of Prostaglandins E1 and E2 in the Guinea Pig" @default.
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- W2149133071 doi "https://doi.org/10.1016/s0021-9258(19)45168-5" @default.
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