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- W2149804554 endingPage "1814" @default.
- W2149804554 startingPage "1807" @default.
- W2149804554 abstract "Previous experiments have indicated that 5' flanking DNA sequences (nucleotides-366 to +46) are capable of regulating the lens-specific transcription of the murine alpha A-crystallin gene. Here we have analyzed these 5' regulatory sequences by transfecting explanted embryonic chicken lens epithelia with different alpha A-crystallin-CAT (chloramphenicol acetyltransferase) hybrid genes (alpha A-crystallin promoter sequences fused to the bacterial CAT gene in the pSVO-CAT expression vector). The results indicated the presence of a proximal (-88 to +46) and a distal (-111 to -88) domain which must interact for promoter function. Deletion experiments showed that the sequence between -88 and -60 was essential for function of the proximal domain in the explanted epithelia. A synthetic oligonucleotide containing the sequence between -111 and -84 activated the proximal domain when placed in either orientation 57 base pairs upstream from position -88 of the alpha A-crystallin-CAT hybrid gene." @default.
- W2149804554 created "2016-06-24" @default.
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- W2149804554 date "1987-05-01" @default.
- W2149804554 modified "2023-10-18" @default.
- W2149804554 title "Interaction between two different regulatory elements activates the murine alpha A-crystallin gene promoter in explanted lens epithelia." @default.
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- W2149804554 doi "https://doi.org/10.1128/mcb.7.5.1807" @default.
- W2149804554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/365283" @default.
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