Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154632002> ?p ?o ?g. }
- W2154632002 endingPage "286" @default.
- W2154632002 startingPage "274" @default.
- W2154632002 abstract "Death receptor-mediated apoptosis has been implicated in target organ destruction in chronic autoimmune thyroiditis. Depending on the circumstances, inflammatory cytokines such as IL-1, TNF and IFNγ have been shown to contribute to either the induction, progression or inhibition of this disease. Here we demonstrate that the death ligand TRAIL can induce apoptosis in primary, normal, thyroid epithelial cells under physiologically relevant conditions, specifically, treatment with the combination of inflammatory cytokines IL-1β and TNFα. In contrast, IFNγ is capable of blocking TRAIL-induced apoptosis in these cells. This regulation of TRAIL-mediated apoptosis by inflammatory cytokines appears to be due to alterations of cell surface expression of TRAIL receptor DR5 and not DR4. We also show the in vivo presence of TRAIL and TRAIL receptors DR5 and DcR1 in both normal and inflamed thyroids. Our data suggests TRAIL-mediated apoptosis may contribute to target organ destruction in chronic autoimmune thyroiditis." @default.
- W2154632002 created "2016-06-24" @default.
- W2154632002 creator A5003171945 @default.
- W2154632002 creator A5009728054 @default.
- W2154632002 creator A5023483009 @default.
- W2154632002 creator A5034045203 @default.
- W2154632002 creator A5054364530 @default.
- W2154632002 creator A5077701232 @default.
- W2154632002 date "2002-02-25" @default.
- W2154632002 modified "2023-10-08" @default.
- W2154632002 title "Inflammatory cytokine regulation of TRAIL-mediated apoptosis in thyroid epithelial cells" @default.
- W2154632002 cites W142053782 @default.
- W2154632002 cites W1514099677 @default.
- W2154632002 cites W1534302749 @default.
- W2154632002 cites W1538959208 @default.
- W2154632002 cites W1597460936 @default.
- W2154632002 cites W1599806854 @default.
- W2154632002 cites W1614587852 @default.
- W2154632002 cites W1869623099 @default.
- W2154632002 cites W1968189869 @default.
- W2154632002 cites W1970490562 @default.
- W2154632002 cites W1971387794 @default.
- W2154632002 cites W1972599408 @default.
- W2154632002 cites W1973792489 @default.
- W2154632002 cites W1978480779 @default.
- W2154632002 cites W1979385116 @default.
- W2154632002 cites W1982836364 @default.
- W2154632002 cites W1995605852 @default.
- W2154632002 cites W1995746773 @default.
- W2154632002 cites W2002937734 @default.
- W2154632002 cites W2008356119 @default.
- W2154632002 cites W2019288826 @default.
- W2154632002 cites W2025044046 @default.
- W2154632002 cites W2029359060 @default.
- W2154632002 cites W2030221255 @default.
- W2154632002 cites W2032396159 @default.
- W2154632002 cites W2032850745 @default.
- W2154632002 cites W2033935793 @default.
- W2154632002 cites W2035877221 @default.
- W2154632002 cites W2037804577 @default.
- W2154632002 cites W2042066081 @default.
- W2154632002 cites W2047278218 @default.
- W2154632002 cites W2049312704 @default.
- W2154632002 cites W2057059673 @default.
- W2154632002 cites W2064127449 @default.
- W2154632002 cites W2069242926 @default.
- W2154632002 cites W2069642280 @default.
- W2154632002 cites W2072014675 @default.
- W2154632002 cites W2076371701 @default.
- W2154632002 cites W2089476060 @default.
- W2154632002 cites W2092196409 @default.
- W2154632002 cites W2092378641 @default.
- W2154632002 cites W2098439946 @default.
- W2154632002 cites W2104985866 @default.
- W2154632002 cites W2108510669 @default.
- W2154632002 cites W2119326933 @default.
- W2154632002 cites W2142790993 @default.
- W2154632002 cites W2159039081 @default.
- W2154632002 cites W2320120629 @default.
- W2154632002 doi "https://doi.org/10.1038/sj.cdd.4400965" @default.
- W2154632002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11859410" @default.
- W2154632002 hasPublicationYear "2002" @default.
- W2154632002 type Work @default.
- W2154632002 sameAs 2154632002 @default.
- W2154632002 citedByCount "35" @default.
- W2154632002 countsByYear W21546320022012 @default.
- W2154632002 countsByYear W21546320022013 @default.
- W2154632002 countsByYear W21546320022014 @default.
- W2154632002 countsByYear W21546320022015 @default.
- W2154632002 countsByYear W21546320022016 @default.
- W2154632002 countsByYear W21546320022017 @default.
- W2154632002 countsByYear W21546320022019 @default.
- W2154632002 countsByYear W21546320022020 @default.
- W2154632002 countsByYear W21546320022021 @default.
- W2154632002 countsByYear W21546320022023 @default.
- W2154632002 crossrefType "journal-article" @default.
- W2154632002 hasAuthorship W2154632002A5003171945 @default.
- W2154632002 hasAuthorship W2154632002A5009728054 @default.
- W2154632002 hasAuthorship W2154632002A5023483009 @default.
- W2154632002 hasAuthorship W2154632002A5034045203 @default.
- W2154632002 hasAuthorship W2154632002A5054364530 @default.
- W2154632002 hasAuthorship W2154632002A5077701232 @default.
- W2154632002 hasBestOaLocation W21546320021 @default.
- W2154632002 hasConcept C126322002 @default.
- W2154632002 hasConcept C134018914 @default.
- W2154632002 hasConcept C164027704 @default.
- W2154632002 hasConcept C170493617 @default.
- W2154632002 hasConcept C17991360 @default.
- W2154632002 hasConcept C190283241 @default.
- W2154632002 hasConcept C203014093 @default.
- W2154632002 hasConcept C2776362883 @default.
- W2154632002 hasConcept C2776914184 @default.
- W2154632002 hasConcept C2778690821 @default.
- W2154632002 hasConcept C2778696486 @default.
- W2154632002 hasConcept C31573885 @default.
- W2154632002 hasConcept C502942594 @default.
- W2154632002 hasConcept C526584372 @default.
- W2154632002 hasConcept C55493867 @default.