FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155115840> ?p ?o ?g. }

• W2155115840 endingPage "7351" @default.
• W2155115840 startingPage "7346" @default.
• W2155115840 abstract "Elevated levels of pro-inflammatory biomarkers have been reported in major depressive disorder (MDD). The aim of this study is to investigate the plasma levels of interleukin-18 (IL-18), macrophageinflammatory protein-1α (MIP-1α), monocyte chemoattractant protein 1 (MCP-1), stromal cell derived factor-1 (SDF-1), and regulated upon activation, normal T cell  expressed and secreted (RANTES) in patients with MDD before and after  eight week treatment of fluoxetine hydrochloride in comparison with normal controls. All subjects were assessed before and after treatment with the Hamilton Depression Rating Scale (HDRS). Our results showed that the symptoms of forty healthy controls and thirty-four patients with MDD were correlated with their plasma levels of IL-18, MIP-1α, MCP-1, SDF-1α, and RANTES. The levels of all five cytokine of patients with MDD were significantly decreased after treatment.  However, the levels remained significantly higher than those of the healthy controls (p<0.001). In the seven depressed subjects whose HDRS score fell to below seven after antidepressant therapy comparing with those subjects whose HDRS score larger than seven, the mean levels of IL-18 (p=0.01) and SDF-1α(p<0.05) were significantly lower. Conversely, higher levels of cytokines correlated with a persistently increased severity of symptoms, as measured by the HDRS scores. In conclusion, these findings suggest that MDD is associated with activation of the immune system, and the antidepressant effect of fluoxetine may be mediated in part through its anti-inflammatory effects. Key words : Fluoxetine hydrochloride, major depression, cytokine, chemokine, inflammation." @default.
• W2155115840 created "2016-06-24" @default.
• W2155115840 creator A5015734390 @default.
• W2155115840 creator A5015900881 @default.
• W2155115840 creator A5018978264 @default.
• W2155115840 creator A5060738858 @default.
• W2155115840 creator A5078511712 @default.
• W2155115840 creator A5079388444 @default.
• W2155115840 date "2010-10-25" @default.
• W2155115840 modified "2023-09-26" @default.
• W2155115840 title "Fluoxetine treatment for major depression decreases the plasma levels of cytokines" @default.
• W2155115840 cites W1978718459 @default.
• W2155115840 cites W1984202178 @default.
• W2155115840 cites W1991636237 @default.
• W2155115840 cites W1991862424 @default.
• W2155115840 cites W1993856151 @default.
• W2155115840 cites W1998520631 @default.
• W2155115840 cites W2022445286 @default.
• W2155115840 cites W2024969297 @default.
• W2155115840 cites W2041298018 @default.
• W2155115840 cites W2045680929 @default.
• W2155115840 cites W2048431959 @default.
• W2155115840 cites W2058243654 @default.
• W2155115840 cites W2078281620 @default.
• W2155115840 cites W2083405172 @default.
• W2155115840 cites W2089285664 @default.
• W2155115840 cites W2095156987 @default.
• W2155115840 cites W2109668208 @default.
• W2155115840 cites W2113354422 @default.
• W2155115840 cites W2115830594 @default.
• W2155115840 cites W2129388599 @default.
• W2155115840 cites W2130685710 @default.
• W2155115840 cites W2140007440 @default.
• W2155115840 cites W91500925 @default.
• W2155115840 doi "https://doi.org/10.5897/ajb10.1097" @default.
• W2155115840 hasPublicationYear "2010" @default.
• W2155115840 type Work @default.
• W2155115840 sameAs 2155115840 @default.
• W2155115840 citedByCount "1" @default.
• W2155115840 countsByYear W21551158402017 @default.
• W2155115840 crossrefType "journal-article" @default.
• W2155115840 hasAuthorship W2155115840A5015734390 @default.
• W2155115840 hasAuthorship W2155115840A5015900881 @default.
• W2155115840 hasAuthorship W2155115840A5018978264 @default.
• W2155115840 hasAuthorship W2155115840A5060738858 @default.
• W2155115840 hasAuthorship W2155115840A5078511712 @default.
• W2155115840 hasAuthorship W2155115840A5079388444 @default.
• W2155115840 hasConcept C126322002 @default.
• W2155115840 hasConcept C13373296 @default.
• W2155115840 hasConcept C134018914 @default.
• W2155115840 hasConcept C138496976 @default.
• W2155115840 hasConcept C139719470 @default.
• W2155115840 hasConcept C15744967 @default.
• W2155115840 hasConcept C162324750 @default.
• W2155115840 hasConcept C170493617 @default.
• W2155115840 hasConcept C2775864247 @default.
• W2155115840 hasConcept C2776134451 @default.
• W2155115840 hasConcept C2776867660 @default.
• W2155115840 hasConcept C2776914184 @default.
• W2155115840 hasConcept C2778690821 @default.
• W2155115840 hasConcept C2779144063 @default.
• W2155115840 hasConcept C2779177272 @default.
• W2155115840 hasConcept C2780051608 @default.
• W2155115840 hasConcept C2781161787 @default.
• W2155115840 hasConcept C2781184567 @default.
• W2155115840 hasConcept C71924100 @default.
• W2155115840 hasConcept C83849319 @default.
• W2155115840 hasConceptScore W2155115840C126322002 @default.
• W2155115840 hasConceptScore W2155115840C13373296 @default.
• W2155115840 hasConceptScore W2155115840C134018914 @default.
• W2155115840 hasConceptScore W2155115840C138496976 @default.
• W2155115840 hasConceptScore W2155115840C139719470 @default.
• W2155115840 hasConceptScore W2155115840C15744967 @default.
• W2155115840 hasConceptScore W2155115840C162324750 @default.
• W2155115840 hasConceptScore W2155115840C170493617 @default.
• W2155115840 hasConceptScore W2155115840C2775864247 @default.
• W2155115840 hasConceptScore W2155115840C2776134451 @default.
• W2155115840 hasConceptScore W2155115840C2776867660 @default.
• W2155115840 hasConceptScore W2155115840C2776914184 @default.
• W2155115840 hasConceptScore W2155115840C2778690821 @default.
• W2155115840 hasConceptScore W2155115840C2779144063 @default.
• W2155115840 hasConceptScore W2155115840C2779177272 @default.
• W2155115840 hasConceptScore W2155115840C2780051608 @default.
• W2155115840 hasConceptScore W2155115840C2781161787 @default.
• W2155115840 hasConceptScore W2155115840C2781184567 @default.
• W2155115840 hasConceptScore W2155115840C71924100 @default.
• W2155115840 hasConceptScore W2155115840C83849319 @default.
• W2155115840 hasIssue "43" @default.
• W2155115840 hasLocation W21551158401 @default.
• W2155115840 hasOpenAccess W2155115840 @default.
• W2155115840 hasPrimaryLocation W21551158401 @default.
• W2155115840 hasRelatedWork W1966523374 @default.
• W2155115840 hasRelatedWork W1985438873 @default.
• W2155115840 hasRelatedWork W2014593621 @default.
• W2155115840 hasRelatedWork W2093749524 @default.
• W2155115840 hasRelatedWork W2094591316 @default.
• W2155115840 hasRelatedWork W2274431116 @default.
• W2155115840 hasRelatedWork W2356301519 @default.

• next