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• W2158384534 abstract "<h3>Background:</h3> Predicting aphasia recovery after stroke has been difficult due to substantial variability in outcomes. Few studies have characterised the nature and extent of recovery, beginning with baselines at 24–72 hours after stroke onset. <h3>Aim:</h3> To characterise the course of language recovery after first-time stroke. <h3>Methods:</h3> Using our Performance and Recovery in Stroke Study (PARIS) database, we evaluated consecutive first-time stroke patients with aphasia and diffusion-weighted-image-positive lesions on admission and at 90 days. <h3>Results:</h3> Twenty-two of 91 patients had language disorders. Initial syndrome scores were positively correlated with 90-day scores (r = 0.60) and negatively correlated with the change in score from baseline to follow-up (r = −0.66). Neither lesion size, age nor education correlated with initial syndrome severity or with performance at 90 days. Level of education was not associated with degree of recovery. A multiple regression model that combined lesion size, age and initial syndrome was significant (p = 0.03) but only explained 29% of the variance. Patients with severe deficits at baseline in individual language domains could recover, improve to a less severe deficit or not improve at all. <h3>Conclusion:</h3> There was significant variability in language recovery after first-time stroke, even in more severe, initial syndromes. Traditional predictors of post-stroke language outcomes did not reliably predict function at 90 days. These data suggest that other factors that account for functional stroke recovery have not yet been identified." @default.
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• W2158384534 date "2008-05-01" @default.
• W2158384534 modified "2023-10-16" @default.
• W2158384534 title "Variability in language recovery after first-time stroke" @default.
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• W2158384534 doi "https://doi.org/10.1136/jnnp.2007.122457" @default.
• W2158384534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17846113" @default.
• W2158384534 hasPublicationYear "2008" @default.
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