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- W2159474178 abstract "Two β-cyclodextrin derivatives with chiral chromophoric substituents, that is, l- (1) and d-tyrosine-modified β-cyclodextrin (2), were synthesized and fully characterized. Their inclusion modes, binding abilities, and molecular selectivities with four steroid guests, that is, cholic acid sodium salt (CA), deoxycholic acid sodium salt (DCA), glycochoic acid sodium salt (GCA), and taurocholic acid sodium salt (TCA), were investigated by the circular dichroism, 2D NMR, and isothermal titration microcalorimetry (ITC). The results obtained from the circular dichroism and 2D NMR showed that two hosts adopted the different binding geometry, and these differences subsequently resulted in the significant differences of molecular binding abilities and selectivities. As compared with native β-cyclodextrin and tryptophan-modified β-cyclodextrin, host 2 showed the enhanced binding abilities for CA and DCA but the decreased binding abilities for GCA and TCA; however, host 1 showed the decreased binding abilities for all four bile salts. The best guest selectivity and the best host selectivity were KS2-DCA/KS2-TCA = 12.6 and KS2-CA/KS1-CA = 10, respectively, both exhibiting great enhancement as compared with the corresponding values of the previously reported l- and d-tryptophan-modified β-cyclodextrins. Thermodynamically, it was the favorable enthalpic gain that led to the high guest selectivity and host selectivity." @default.
- W2159474178 created "2016-06-24" @default.
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- W2159474178 date "2010-08-09" @default.
- W2159474178 modified "2023-09-24" @default.
- W2159474178 title "Thermodynamic Origin of Selective Binding of β-Cyclodextrin Derivatives with Chiral Chromophoric Substituents toward Steroids" @default.
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- W2159474178 doi "https://doi.org/10.1021/jp105821s" @default.
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