Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162242806> ?p ?o ?g. }
- W2162242806 endingPage "685" @default.
- W2162242806 startingPage "669" @default.
- W2162242806 abstract "The chemical basis for the alternating antigenic change called form variation noted for the Escherichia coli K1-capsular polysaccharide has been shown by 13C nuclear magnetic resonance to be a result of random O-acetylation of C7 and C9 carbons of the alpha-2-8-linked sialic acid homopolymer. A serologic method (antiserum agar) was developed to identify and isolate the form variants. The O-acetyl positive and O-acetyl negative K1 polysaccharides had unique biochemical and immunologic properties. The O-acetyl-positive variants resisted neuraminidase hydrolysis in contrast to the susceptibility of the O-acetyl negative variant to this enzyme. In addition, O-acetylation altered the antigenicity of the O-acetyl polysaccharides. When injected as whole organisms, O-acetyl positive organisms produced anti-K1 -antibodies in rabbits specific for this polysaccharide variant. O-acetyl negative organisms were comparatively less immunogenic; however, antibodies induced by these organisms reacted with both K1 polysaccharide variants. Burros, injected with either variant, produced antibodies reactive with both K1 polysaccharides." @default.
- W2162242806 created "2016-06-24" @default.
- W2162242806 creator A5010131922 @default.
- W2162242806 creator A5018191939 @default.
- W2162242806 creator A5032026651 @default.
- W2162242806 creator A5062122676 @default.
- W2162242806 creator A5070191522 @default.
- W2162242806 creator A5078302103 @default.
- W2162242806 creator A5084181720 @default.
- W2162242806 creator A5088122020 @default.
- W2162242806 date "1979-03-01" @default.
- W2162242806 modified "2023-10-14" @default.
- W2162242806 title "Form variation in Escherichia coli K1: determined by O-acetylation of the capsular polysaccharide." @default.
- W2162242806 cites W104305327 @default.
- W2162242806 cites W1515195345 @default.
- W2162242806 cites W1536299500 @default.
- W2162242806 cites W1543028214 @default.
- W2162242806 cites W1558677968 @default.
- W2162242806 cites W1568082126 @default.
- W2162242806 cites W1580023435 @default.
- W2162242806 cites W1586175429 @default.
- W2162242806 cites W1594474422 @default.
- W2162242806 cites W1597014450 @default.
- W2162242806 cites W1766328979 @default.
- W2162242806 cites W1775749144 @default.
- W2162242806 cites W1778109206 @default.
- W2162242806 cites W1779971137 @default.
- W2162242806 cites W1847909978 @default.
- W2162242806 cites W1892638700 @default.
- W2162242806 cites W1904058845 @default.
- W2162242806 cites W1931248347 @default.
- W2162242806 cites W1944959511 @default.
- W2162242806 cites W1965634723 @default.
- W2162242806 cites W1970297725 @default.
- W2162242806 cites W1982282046 @default.
- W2162242806 cites W1986147894 @default.
- W2162242806 cites W1986537688 @default.
- W2162242806 cites W1995229546 @default.
- W2162242806 cites W2010840339 @default.
- W2162242806 cites W2045240085 @default.
- W2162242806 cites W2046015569 @default.
- W2162242806 cites W2054495382 @default.
- W2162242806 cites W2060099924 @default.
- W2162242806 cites W2070060959 @default.
- W2162242806 cites W2075777104 @default.
- W2162242806 cites W2076746885 @default.
- W2162242806 cites W2078508999 @default.
- W2162242806 cites W2084449696 @default.
- W2162242806 cites W2094437035 @default.
- W2162242806 cites W2149165097 @default.
- W2162242806 cites W2152535479 @default.
- W2162242806 cites W2157343747 @default.
- W2162242806 cites W2167896930 @default.
- W2162242806 cites W2169823848 @default.
- W2162242806 cites W2402030148 @default.
- W2162242806 cites W2411972553 @default.
- W2162242806 cites W2413919979 @default.
- W2162242806 cites W4231386602 @default.
- W2162242806 doi "https://doi.org/10.1084/jem.149.3.669" @default.
- W2162242806 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2184817" @default.
- W2162242806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/372481" @default.
- W2162242806 hasPublicationYear "1979" @default.
- W2162242806 type Work @default.
- W2162242806 sameAs 2162242806 @default.
- W2162242806 citedByCount "199" @default.
- W2162242806 countsByYear W21622428062012 @default.
- W2162242806 countsByYear W21622428062013 @default.
- W2162242806 countsByYear W21622428062014 @default.
- W2162242806 countsByYear W21622428062015 @default.
- W2162242806 countsByYear W21622428062016 @default.
- W2162242806 countsByYear W21622428062017 @default.
- W2162242806 countsByYear W21622428062018 @default.
- W2162242806 countsByYear W21622428062019 @default.
- W2162242806 countsByYear W21622428062021 @default.
- W2162242806 countsByYear W21622428062022 @default.
- W2162242806 crossrefType "journal-article" @default.
- W2162242806 hasAuthorship W2162242806A5010131922 @default.
- W2162242806 hasAuthorship W2162242806A5018191939 @default.
- W2162242806 hasAuthorship W2162242806A5032026651 @default.
- W2162242806 hasAuthorship W2162242806A5062122676 @default.
- W2162242806 hasAuthorship W2162242806A5070191522 @default.
- W2162242806 hasAuthorship W2162242806A5078302103 @default.
- W2162242806 hasAuthorship W2162242806A5084181720 @default.
- W2162242806 hasAuthorship W2162242806A5088122020 @default.
- W2162242806 hasBestOaLocation W21622428061 @default.
- W2162242806 hasConcept C100817775 @default.
- W2162242806 hasConcept C104317684 @default.
- W2162242806 hasConcept C119157956 @default.
- W2162242806 hasConcept C134164806 @default.
- W2162242806 hasConcept C147483822 @default.
- W2162242806 hasConcept C159654299 @default.
- W2162242806 hasConcept C181199279 @default.
- W2162242806 hasConcept C185592680 @default.
- W2162242806 hasConcept C203014093 @default.
- W2162242806 hasConcept C2779026604 @default.
- W2162242806 hasConcept C2780115458 @default.
- W2162242806 hasConcept C54355233 @default.
- W2162242806 hasConcept C547475151 @default.