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- W2165655376 abstract "This review focuses on recent progress in the in vitro lipid digestion models and how these models can underpin in vitro-in vivo correlations which are a key element for drug development. A plethora of articles are dealing with development of lipid-based formulations of poorly soluble compounds for oral administration; however, most studies base formulation development and proof of concept on bioavailability studies and do not consider the use of in vitro studies. A major challenge is the development of in vitro models simulating the gastric or intestinal fluids to assess their in vivo performance. The use of in vitro lipolysis models has been proposed as an approach to probe solubilisation in the aqueous phase during the progress of enzymatic degradation of lipid based-formulations. Moreover, the in vitro digestion models, coupled with biophysical methods, offer insights into the mechanisms underlying lipid digestion, by characterising the generated intermediate colloidal phases, and thereby can serve as a screening tool for designing and optimising lipid-based formulations." @default.
- W2165655376 created "2016-06-24" @default.
- W2165655376 creator A5064072022 @default.
- W2165655376 creator A5091628026 @default.
- W2165655376 date "2007-12-21" @default.
- W2165655376 modified "2023-10-12" @default.
- W2165655376 title "<i>In vitro</i>lipid digestion models in design of drug delivery systems for enhancing oral bioavailability" @default.
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- W2165655376 doi "https://doi.org/10.1517/17425255.4.1.65" @default.
- W2165655376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18370859" @default.
- W2165655376 hasPublicationYear "2007" @default.
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