FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167673124> ?p ?o ?g. }

• W2167673124 endingPage "311" @default.
• W2167673124 startingPage "301" @default.
• W2167673124 abstract "1. Cacospongionolide B is a novel marine metabolite isolated from the sponge Fasciospongia cavernosa. In in vitro studies, this compound inhibited phospholipase A2 (PLA2), showing selectivity for secretory PLA2 (sPLA2) versus cytosolic PLA2 (cPLA2), and its potency on the human synovial enzyme (group II) was similar to that of manoalide. 2. This activity was confirmed in vivo in the 8 h zymosan-injected rat air pouch, on the secretory enzyme accumulating in the pouch exudate. Cacospongionolide B, that is bioavailable when is given orally, reduced the elevated levels of sPLA2 present in paw homogenates of rats with adjuvant arthritis. 3. This marine metabolite showed topical anti-inflammatory activity on the mouse ear oedema induced by 12-O-tetradecanoylphorbol acetate (TPA) and decreased carrageenin paw oedema in mice after oral administration of 5, 10 or 20 mg kg(-1). 4. In the mouse air pouch injected with zymosan, cacospongionolide B administered into the pouch, induced a dose-dependent reduction in the levels of eicosanoids and tumour necrosis factor alpha (TNFalpha) in the exudates 4 h after the stimulus. It also had a weak effect on cell migration. 5. The inflammatory response of adjuvant arthritis was reduced by cacospongionolide B, which did not significantly affect eicosanoid levels in serum, paw or stomach homogenates and did not induce toxic effects. 6 Cacospongionolide B is a new inhibitor of sPLA2 in vitro and in vivo, with anti-inflammatory properties in acute and chronic inflammation. This marine metabolite was active after oral administration and able to modify TNFalpha levels, and may offer an interesting approach in the search for new anti-inflammatory agents." @default.
• W2167673124 created "2016-06-24" @default.
• W2167673124 creator A5000688083 @default.
• W2167673124 creator A5022180329 @default.
• W2167673124 creator A5039638412 @default.
• W2167673124 creator A5045289907 @default.
• W2167673124 creator A5091215334 @default.
• W2167673124 date "1999-01-01" @default.
• W2167673124 modified "2023-10-14" @default.
• W2167673124 title "Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A₂" @default.
• W2167673124 cites W1480708545 @default.
• W2167673124 cites W1500692723 @default.
• W2167673124 cites W1503779966 @default.
• W2167673124 cites W1516262714 @default.
• W2167673124 cites W1527859504 @default.
• W2167673124 cites W1552523643 @default.
• W2167673124 cites W1587885075 @default.
• W2167673124 cites W162206855 @default.
• W2167673124 cites W1639924204 @default.
• W2167673124 cites W1641540149 @default.
• W2167673124 cites W1664326306 @default.
• W2167673124 cites W1675755394 @default.
• W2167673124 cites W1773327886 @default.
• W2167673124 cites W1790333260 @default.
• W2167673124 cites W1793993480 @default.
• W2167673124 cites W1826923758 @default.
• W2167673124 cites W1832048578 @default.
• W2167673124 cites W1909364359 @default.
• W2167673124 cites W1957842281 @default.
• W2167673124 cites W1966450126 @default.
• W2167673124 cites W1968427039 @default.
• W2167673124 cites W1978139515 @default.
• W2167673124 cites W1978791534 @default.
• W2167673124 cites W1979279094 @default.
• W2167673124 cites W1981592867 @default.
• W2167673124 cites W1986462191 @default.
• W2167673124 cites W1986872682 @default.
• W2167673124 cites W1987056475 @default.
• W2167673124 cites W1988806198 @default.
• W2167673124 cites W1992641427 @default.
• W2167673124 cites W1992809091 @default.
• W2167673124 cites W1993267975 @default.
• W2167673124 cites W199761710 @default.
• W2167673124 cites W2005787424 @default.
• W2167673124 cites W2009676510 @default.
• W2167673124 cites W2019270299 @default.
• W2167673124 cites W2024191096 @default.
• W2167673124 cites W2026457555 @default.
• W2167673124 cites W2027009883 @default.
• W2167673124 cites W2028294428 @default.
• W2167673124 cites W2030285475 @default.
• W2167673124 cites W2031661090 @default.
• W2167673124 cites W2032523595 @default.
• W2167673124 cites W2032596085 @default.
• W2167673124 cites W2036074288 @default.
• W2167673124 cites W2039919573 @default.
• W2167673124 cites W2040220172 @default.
• W2167673124 cites W2040827725 @default.
• W2167673124 cites W2041299660 @default.
• W2167673124 cites W2041710280 @default.
• W2167673124 cites W2043248226 @default.
• W2167673124 cites W2055058809 @default.
• W2167673124 cites W2057345518 @default.
• W2167673124 cites W2060241486 @default.
• W2167673124 cites W2062152487 @default.
• W2167673124 cites W2062848455 @default.
• W2167673124 cites W2064655962 @default.
• W2167673124 cites W2068539359 @default.
• W2167673124 cites W2073281731 @default.
• W2167673124 cites W2079846327 @default.
• W2167673124 cites W2084139809 @default.
• W2167673124 cites W2105274078 @default.
• W2167673124 cites W2128454894 @default.
• W2167673124 cites W2128635872 @default.
• W2167673124 cites W2184428827 @default.
• W2167673124 cites W2198929140 @default.
• W2167673124 cites W2338274265 @default.
• W2167673124 cites W2401209172 @default.
• W2167673124 cites W2403526408 @default.
• W2167673124 cites W2415016710 @default.
• W2167673124 cites W2951822190 @default.
• W2167673124 cites W4293247451 @default.
• W2167673124 doi "https://doi.org/10.1038/sj.bjp.0702302" @default.
• W2167673124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1565805" @default.
• W2167673124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10051149" @default.
• W2167673124 hasPublicationYear "1999" @default.
• W2167673124 type Work @default.
• W2167673124 sameAs 2167673124 @default.
• W2167673124 citedByCount "42" @default.
• W2167673124 countsByYear W21676731242012 @default.
• W2167673124 countsByYear W21676731242013 @default.
• W2167673124 countsByYear W21676731242015 @default.
• W2167673124 countsByYear W21676731242016 @default.
• W2167673124 countsByYear W21676731242018 @default.
• W2167673124 countsByYear W21676731242020 @default.
• W2167673124 crossrefType "journal-article" @default.
• W2167673124 hasAuthorship W2167673124A5000688083 @default.
• W2167673124 hasAuthorship W2167673124A5022180329 @default.

• next