Matches in SemOpenAlex for { <https://semopenalex.org/work/W2170203080> ?p ?o ?g. }
- W2170203080 endingPage "73" @default.
- W2170203080 startingPage "464" @default.
- W2170203080 abstract "Some dihydropyridines (DHPs), such as amlodipine and cilnidipine, have been shown to block not only L-type but also N-type Ca(2+) channels; therefore, DHPs are no longer considered as L-type-specific Ca(2+) channel blockers. However, selectivity of DHPs for Ca(2+) channel subtypes including N-, P/Q-, and R-types are poorly understood. To address this issue at the molecular level, blocking effects of 10 DHPs (nifedipine, nilvadipine, barnidipine, nimodipine, nitrendipine, amlodipine, nicardipine, benidipine, felodipine, and cilnidipine) on four subtypes of Ca(2+) channels (L-, N-, P/Q-, and R-types) were investigated in the Xenopus oocyte expression system with the use of the two-microelectrode voltage-clamp technique. L-type Ca(2+) channels expressed as alpha(1C)alpha(2)beta(1a) combination were profoundly blocked by all DHPs examined, whereas blocking actions of these DHPs on R-type (alpha(1E)alpha(2)beta(1a)) channels were equally weak. In contrast, 5 of the 10 DHPs (amlodipine, benidipine, cilnidipine, nicardipine, and barnidipine) significantly blocked N-type (alpha(1B)alpha(2)beta(1a)) and P/Q-type (alpha(1A)alpha(2)beta(1a)) Ca(2+) channels. These selectivities of DHPs in blocking Ca(2+) channel subtypes would provide useful pharmacological and clinical information on the mode of action of the drugs including side effects and adverse effects." @default.
- W2170203080 created "2016-06-24" @default.
- W2170203080 creator A5000922366 @default.
- W2170203080 creator A5004337159 @default.
- W2170203080 creator A5033911854 @default.
- W2170203080 creator A5063951125 @default.
- W2170203080 creator A5073328436 @default.
- W2170203080 creator A5078967543 @default.
- W2170203080 date "1999-11-01" @default.
- W2170203080 modified "2023-09-29" @default.
- W2170203080 title "Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes." @default.
- W2170203080 cites W135220819 @default.
- W2170203080 cites W1496951250 @default.
- W2170203080 cites W1777610481 @default.
- W2170203080 cites W1963848815 @default.
- W2170203080 cites W1976581530 @default.
- W2170203080 cites W1977136952 @default.
- W2170203080 cites W1977742032 @default.
- W2170203080 cites W1985957556 @default.
- W2170203080 cites W1986765615 @default.
- W2170203080 cites W1987037902 @default.
- W2170203080 cites W1987875250 @default.
- W2170203080 cites W1992609614 @default.
- W2170203080 cites W1993769979 @default.
- W2170203080 cites W2003271176 @default.
- W2170203080 cites W2008709484 @default.
- W2170203080 cites W2011765859 @default.
- W2170203080 cites W2016115668 @default.
- W2170203080 cites W2017326295 @default.
- W2170203080 cites W2023331462 @default.
- W2170203080 cites W2026183815 @default.
- W2170203080 cites W2036937904 @default.
- W2170203080 cites W2043759997 @default.
- W2170203080 cites W2052044716 @default.
- W2170203080 cites W2054984084 @default.
- W2170203080 cites W2081491508 @default.
- W2170203080 cites W2081841708 @default.
- W2170203080 cites W2082120373 @default.
- W2170203080 cites W2082592627 @default.
- W2170203080 cites W2084446244 @default.
- W2170203080 cites W2090157435 @default.
- W2170203080 cites W2101072772 @default.
- W2170203080 cites W2106138867 @default.
- W2170203080 cites W2108356735 @default.
- W2170203080 cites W2108604849 @default.
- W2170203080 cites W2121792002 @default.
- W2170203080 cites W2136065229 @default.
- W2170203080 cites W2145565753 @default.
- W2170203080 cites W2149361059 @default.
- W2170203080 cites W2157283223 @default.
- W2170203080 cites W2157731351 @default.
- W2170203080 cites W2171682691 @default.
- W2170203080 cites W2226325292 @default.
- W2170203080 cites W2247893933 @default.
- W2170203080 cites W2495249009 @default.
- W2170203080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10525060" @default.
- W2170203080 hasPublicationYear "1999" @default.
- W2170203080 type Work @default.
- W2170203080 sameAs 2170203080 @default.
- W2170203080 citedByCount "35" @default.
- W2170203080 countsByYear W21702030802012 @default.
- W2170203080 countsByYear W21702030802013 @default.
- W2170203080 countsByYear W21702030802015 @default.
- W2170203080 countsByYear W21702030802016 @default.
- W2170203080 countsByYear W21702030802017 @default.
- W2170203080 countsByYear W21702030802018 @default.
- W2170203080 crossrefType "journal-article" @default.
- W2170203080 hasAuthorship W2170203080A5000922366 @default.
- W2170203080 hasAuthorship W2170203080A5004337159 @default.
- W2170203080 hasAuthorship W2170203080A5033911854 @default.
- W2170203080 hasAuthorship W2170203080A5063951125 @default.
- W2170203080 hasAuthorship W2170203080A5073328436 @default.
- W2170203080 hasAuthorship W2170203080A5078967543 @default.
- W2170203080 hasConcept C134018914 @default.
- W2170203080 hasConcept C178790620 @default.
- W2170203080 hasConcept C185592680 @default.
- W2170203080 hasConcept C18699975 @default.
- W2170203080 hasConcept C203014093 @default.
- W2170203080 hasConcept C2778043224 @default.
- W2170203080 hasConcept C2778048844 @default.
- W2170203080 hasConcept C2778371730 @default.
- W2170203080 hasConcept C2779066535 @default.
- W2170203080 hasConcept C2779646130 @default.
- W2170203080 hasConcept C2780548744 @default.
- W2170203080 hasConcept C2780866276 @default.
- W2170203080 hasConcept C2781212610 @default.
- W2170203080 hasConcept C519063684 @default.
- W2170203080 hasConcept C71924100 @default.
- W2170203080 hasConcept C84393581 @default.
- W2170203080 hasConcept C85520022 @default.
- W2170203080 hasConcept C98274493 @default.
- W2170203080 hasConceptScore W2170203080C134018914 @default.
- W2170203080 hasConceptScore W2170203080C178790620 @default.
- W2170203080 hasConceptScore W2170203080C185592680 @default.
- W2170203080 hasConceptScore W2170203080C18699975 @default.
- W2170203080 hasConceptScore W2170203080C203014093 @default.
- W2170203080 hasConceptScore W2170203080C2778043224 @default.
- W2170203080 hasConceptScore W2170203080C2778048844 @default.