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• W2170250614 abstract "Wurst is a protein threading program with an emphasis on high quality sequence to structure alignments (http://www.zbh.uni-hamburg.de/wurst). Submitted sequences are aligned to each of about 3000 templates with a conventional dynamic programming algorithm, but using a score function with sophisticated structure and sequence terms. The structure terms are a log-odds probability of sequence to structure fragment compatibility, obtained from a Bayesian classification procedure. A simplex optimization was used to optimize the sequence-based terms for the goal of alignment and model quality and to balance the sequence and structural contributions against each other. Both sequence and structural terms operate with sequence profiles." @default.
• W2170250614 created "2016-06-24" @default.
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• W2170250614 date "2004-07-01" @default.
• W2170250614 modified "2023-09-25" @default.
• W2170250614 title "Wurst: a protein threading server with a structural scoring function, sequence profiles and optimized substitution matrices" @default.
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• W2170250614 doi "https://doi.org/10.1093/nar/gkh357" @default.
• W2170250614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/441495" @default.
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