Matches in SemOpenAlex for { <https://semopenalex.org/work/W2171915544> ?p ?o ?g. }
- W2171915544 endingPage "418" @default.
- W2171915544 startingPage "405" @default.
- W2171915544 abstract "Objective. The aim of this study was to examine the association of apolipoprotein E (APOE) genotypes and oxidative stress with the risk of mild and severe preeclampsia. Methods. In a case–control study, 198 women with preeclampsia including 128 women with mild and 70 women with severe preeclampsia and 101 control pregnant women from Western Iran were studied. The APOE genotypes were identified using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) method. The serum level of malondialdehyde (MDA) and total antioxidant capacity (TAC) were determined using high-performance liquid chromatography and commercial kits, respectively. Results. The frequency of APOE ϵ2 allele in severe preeclamptic women (2.1%) was significantly (p = 0.008) lower than that in controls (9.4%). The presence of APOE ϵ2 allele was associated with around five times decreased risk of severe preeclampsia [OR = 0.21 (95% CI = 0.6–0.73, p = 0.014)]. A significantly higher serum level of MDA was observed in women with severe (10.87 ± 4.61 μM) and mild (9.81 ± 3.67 μM) preeclampsia compared with that in controls. A trend toward decrease serum level of MDA was observed according to the APOE alleles as ϵ2 < ϵ3 < ϵ4 (9.23, 10.22, and 10.43 μM, respectively). In preeclamptic women, an inverse correlation was detected between serum levels of MDA and HDL-C (r = −0.16, p = 0.029). However, there was a direct correlation between serum level of MDA with diastolic blood pressure (r = 0.15, p = 0.037). Conclusion. Our study in a population with Kurdish ethnic background indicates a protective role for APOE ϵ2 allele against severe preeclampsia that might be through high antioxidant capacity of this allele." @default.
- W2171915544 created "2016-06-24" @default.
- W2171915544 creator A5004145483 @default.
- W2171915544 creator A5027415970 @default.
- W2171915544 creator A5028853982 @default.
- W2171915544 creator A5033307009 @default.
- W2171915544 creator A5052029007 @default.
- W2171915544 date "2012-06-07" @default.
- W2171915544 modified "2023-09-25" @default.
- W2171915544 title "Apolipoprotein E Genotypes, Lipid Peroxidation, and Antioxidant Status among Mild and Severe Preeclamptic Women from Western Iran: Protective Role of Apolipoprotein ϵ2 Allele in Severe Preeclampsia" @default.
- W2171915544 cites W1978170233 @default.
- W2171915544 cites W1986956193 @default.
- W2171915544 cites W1992549036 @default.
- W2171915544 cites W1998903249 @default.
- W2171915544 cites W2000018508 @default.
- W2171915544 cites W2003553246 @default.
- W2171915544 cites W2009069392 @default.
- W2171915544 cites W2009780409 @default.
- W2171915544 cites W2011916431 @default.
- W2171915544 cites W2019779869 @default.
- W2171915544 cites W2020658848 @default.
- W2171915544 cites W2026720710 @default.
- W2171915544 cites W2027146753 @default.
- W2171915544 cites W2033041218 @default.
- W2171915544 cites W2049794503 @default.
- W2171915544 cites W2057398928 @default.
- W2171915544 cites W2057930809 @default.
- W2171915544 cites W2088260245 @default.
- W2171915544 cites W2117078571 @default.
- W2171915544 cites W2126962828 @default.
- W2171915544 cites W2132817649 @default.
- W2171915544 cites W2147155212 @default.
- W2171915544 cites W2147568679 @default.
- W2171915544 cites W2168243666 @default.
- W2171915544 cites W2170624859 @default.
- W2171915544 doi "https://doi.org/10.3109/10641955.2012.690055" @default.
- W2171915544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22676395" @default.
- W2171915544 hasPublicationYear "2012" @default.
- W2171915544 type Work @default.
- W2171915544 sameAs 2171915544 @default.
- W2171915544 citedByCount "16" @default.
- W2171915544 countsByYear W21719155442013 @default.
- W2171915544 countsByYear W21719155442014 @default.
- W2171915544 countsByYear W21719155442017 @default.
- W2171915544 countsByYear W21719155442019 @default.
- W2171915544 countsByYear W21719155442020 @default.
- W2171915544 countsByYear W21719155442021 @default.
- W2171915544 countsByYear W21719155442022 @default.
- W2171915544 countsByYear W21719155442023 @default.
- W2171915544 crossrefType "journal-article" @default.
- W2171915544 hasAuthorship W2171915544A5004145483 @default.
- W2171915544 hasAuthorship W2171915544A5027415970 @default.
- W2171915544 hasAuthorship W2171915544A5028853982 @default.
- W2171915544 hasAuthorship W2171915544A5033307009 @default.
- W2171915544 hasAuthorship W2171915544A5052029007 @default.
- W2171915544 hasConcept C104317684 @default.
- W2171915544 hasConcept C126322002 @default.
- W2171915544 hasConcept C134018914 @default.
- W2171915544 hasConcept C135763542 @default.
- W2171915544 hasConcept C180754005 @default.
- W2171915544 hasConcept C2776151105 @default.
- W2171915544 hasConcept C2777218350 @default.
- W2171915544 hasConcept C2778163477 @default.
- W2171915544 hasConcept C2778401633 @default.
- W2171915544 hasConcept C2779134260 @default.
- W2171915544 hasConcept C2779234561 @default.
- W2171915544 hasConcept C2780829032 @default.
- W2171915544 hasConcept C54355233 @default.
- W2171915544 hasConcept C57089818 @default.
- W2171915544 hasConcept C62746215 @default.
- W2171915544 hasConcept C71924100 @default.
- W2171915544 hasConcept C86803240 @default.
- W2171915544 hasConceptScore W2171915544C104317684 @default.
- W2171915544 hasConceptScore W2171915544C126322002 @default.
- W2171915544 hasConceptScore W2171915544C134018914 @default.
- W2171915544 hasConceptScore W2171915544C135763542 @default.
- W2171915544 hasConceptScore W2171915544C180754005 @default.
- W2171915544 hasConceptScore W2171915544C2776151105 @default.
- W2171915544 hasConceptScore W2171915544C2777218350 @default.
- W2171915544 hasConceptScore W2171915544C2778163477 @default.
- W2171915544 hasConceptScore W2171915544C2778401633 @default.
- W2171915544 hasConceptScore W2171915544C2779134260 @default.
- W2171915544 hasConceptScore W2171915544C2779234561 @default.
- W2171915544 hasConceptScore W2171915544C2780829032 @default.
- W2171915544 hasConceptScore W2171915544C54355233 @default.
- W2171915544 hasConceptScore W2171915544C57089818 @default.
- W2171915544 hasConceptScore W2171915544C62746215 @default.
- W2171915544 hasConceptScore W2171915544C71924100 @default.
- W2171915544 hasConceptScore W2171915544C86803240 @default.
- W2171915544 hasIssue "4" @default.
- W2171915544 hasLocation W21719155441 @default.
- W2171915544 hasLocation W21719155442 @default.
- W2171915544 hasOpenAccess W2171915544 @default.
- W2171915544 hasPrimaryLocation W21719155441 @default.
- W2171915544 hasRelatedWork W2003553246 @default.
- W2171915544 hasRelatedWork W2014928985 @default.
- W2171915544 hasRelatedWork W2019231080 @default.
- W2171915544 hasRelatedWork W2087988951 @default.