FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2173193594> ?p ?o ?g. }

• W2173193594 endingPage "192" @default.
• W2173193594 startingPage "178" @default.
• W2173193594 abstract "Mesenchymal stem cells (MSCs)-based therapy provides a promising therapy for the ischemic heart disease (IHD). However, engrafted MSCs are subjected to acute cell death in the ischemic microenvironment, characterized by excessive inflammation and oxidative stress in the host's infarcted myocardium. Melatonin, an indole, which is produced by many organs including pineal gland, has been shown to protect bone marrow MSCs against apoptosis although the mechanism of action remains elusive. Using a murine model of myocardial infarction (MI), this study was designed to evaluate the impact of melatonin on adipose-derived mesenchymal stem cells (AD-MSCs)-based therapy for MI and the underlying mechanism involved with a focus on silent information regulator 1(SIRT1) signaling. Our results demonstrated that melatonin promoted functional survival of AD-MSCs in infarcted heart and provoked a synergetic effect with AD-MSCs to restore heart function. This in vivo effect of melatonin was associated with alleviated inflammation, apoptosis, and oxidative stress in infarcted heart. In vitro studies revealed that melatonin exert cytoprotective effects on AD-MSCs against hypoxia/serum deprivation (H/SD) injury via attenuating inflammation, apoptosis, and oxidative stress. Mechanistically, melatonin enhanced SIRT1 signaling, which was accompanied with the increased expression of anti-apoptotic protein Bcl2, and decreased the expression of Ac-FoxO1, Ac-p53, Ac-NF-ΚB, and Bax. Taken together, our findings indicated that melatonin facilitated AD-MSCs-based therapy in MI, possibly through promoting survival of AD-MSCs via SIRT1 signaling. Our data support the promise of melatonin as a novel strategy to improve MSC-based therapy for IHD, possibly through SIRT1 signaling evocation." @default.
• W2173193594 created "2016-06-24" @default.
• W2173193594 creator A5002459398 @default.
• W2173193594 creator A5007592619 @default.
• W2173193594 creator A5019256596 @default.
• W2173193594 creator A5019266355 @default.
• W2173193594 creator A5028238350 @default.
• W2173193594 creator A5036269926 @default.
• W2173193594 creator A5044556689 @default.
• W2173193594 creator A5050707734 @default.
• W2173193594 creator A5051863134 @default.
• W2173193594 creator A5061066610 @default.
• W2173193594 creator A5066599687 @default.
• W2173193594 creator A5082278334 @default.
• W2173193594 date "2015-12-17" @default.
• W2173193594 modified "2023-10-14" @default.
• W2173193594 title "Melatonin facilitates adipose-derived mesenchymal stem cells to repair the murine infarcted heart <i>via</i> the SIRT1 signaling pathway" @default.
• W2173193594 cites W1566998770 @default.
• W2173193594 cites W1583940256 @default.
• W2173193594 cites W1754595315 @default.
• W2173193594 cites W1859112706 @default.
• W2173193594 cites W1926960484 @default.
• W2173193594 cites W1934204403 @default.
• W2173193594 cites W1943985293 @default.
• W2173193594 cites W1954154747 @default.
• W2173193594 cites W1973935082 @default.
• W2173193594 cites W1975364680 @default.
• W2173193594 cites W1984663488 @default.
• W2173193594 cites W1998650056 @default.
• W2173193594 cites W2000599108 @default.
• W2173193594 cites W2003523703 @default.
• W2173193594 cites W2006022385 @default.
• W2173193594 cites W2011176180 @default.
• W2173193594 cites W2015063933 @default.
• W2173193594 cites W2018491379 @default.
• W2173193594 cites W2019922945 @default.
• W2173193594 cites W2021110745 @default.
• W2173193594 cites W2029716822 @default.
• W2173193594 cites W2031142646 @default.
• W2173193594 cites W2031661979 @default.
• W2173193594 cites W2031812866 @default.
• W2173193594 cites W2033548502 @default.
• W2173193594 cites W2035000104 @default.
• W2173193594 cites W2039601697 @default.
• W2173193594 cites W2041379622 @default.
• W2173193594 cites W2045282478 @default.
• W2173193594 cites W2049994495 @default.
• W2173193594 cites W2050544896 @default.
• W2173193594 cites W2053134443 @default.
• W2173193594 cites W2060309907 @default.
• W2173193594 cites W2066035077 @default.
• W2173193594 cites W2067591094 @default.
• W2173193594 cites W2075888096 @default.
• W2173193594 cites W2081707922 @default.
• W2173193594 cites W2082967353 @default.
• W2173193594 cites W2084806669 @default.
• W2173193594 cites W2085287764 @default.
• W2173193594 cites W2098076364 @default.
• W2173193594 cites W2102085357 @default.
• W2173193594 cites W2105368168 @default.
• W2173193594 cites W2111178335 @default.
• W2173193594 cites W2114102299 @default.
• W2173193594 cites W2117205119 @default.
• W2173193594 cites W2118995107 @default.
• W2173193594 cites W2125065061 @default.
• W2173193594 cites W2138386511 @default.
• W2173193594 cites W2153570744 @default.
• W2173193594 cites W2166040185 @default.
• W2173193594 cites W4231050902 @default.
• W2173193594 doi "https://doi.org/10.1111/jpi.12299" @default.
• W2173193594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26607398" @default.
• W2173193594 hasPublicationYear "2015" @default.
• W2173193594 type Work @default.
• W2173193594 sameAs 2173193594 @default.
• W2173193594 citedByCount "96" @default.
• W2173193594 countsByYear W21731935942016 @default.
• W2173193594 countsByYear W21731935942017 @default.
• W2173193594 countsByYear W21731935942018 @default.
• W2173193594 countsByYear W21731935942019 @default.
• W2173193594 countsByYear W21731935942020 @default.
• W2173193594 countsByYear W21731935942021 @default.
• W2173193594 countsByYear W21731935942022 @default.
• W2173193594 countsByYear W21731935942023 @default.
• W2173193594 crossrefType "journal-article" @default.
• W2173193594 hasAuthorship W2173193594A5002459398 @default.
• W2173193594 hasAuthorship W2173193594A5007592619 @default.
• W2173193594 hasAuthorship W2173193594A5019256596 @default.
• W2173193594 hasAuthorship W2173193594A5019266355 @default.
• W2173193594 hasAuthorship W2173193594A5028238350 @default.
• W2173193594 hasAuthorship W2173193594A5036269926 @default.
• W2173193594 hasAuthorship W2173193594A5044556689 @default.
• W2173193594 hasAuthorship W2173193594A5050707734 @default.
• W2173193594 hasAuthorship W2173193594A5051863134 @default.
• W2173193594 hasAuthorship W2173193594A5061066610 @default.
• W2173193594 hasAuthorship W2173193594A5066599687 @default.
• W2173193594 hasAuthorship W2173193594A5082278334 @default.
• W2173193594 hasConcept C134018914 @default.
• W2173193594 hasConcept C190283241 @default.

• next