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• W2174239302 startingPage "269" @default.
• W2174239302 abstract "By studying literature data and having performed an in silico analysis, the circulating microRNA expression profiles of healthy individuals appear to show an abundance of microRNAs with predominant tumor suppressor activity. We hypothesize that circulating tumor suppressor microRNAs might constitute a sort of continuous tumor surveillance, whereby circulating microRNAs delivering gene expression modulating epigenetic information might halt cell transformation and tumorigenesis. This mechanism might complement the well-known cancer immune surveillance. A further hypothesis is also discussed, supposing that the tissue specific action of microRNAs might represent a putative defense mechanism against the potential tumor-promoting actions of secreted miRNA." @default.
• W2174239302 created "2016-06-24" @default.
• W2174239302 creator A5046373494 @default.
• W2174239302 creator A5055346687 @default.
• W2174239302 date "2015-01-01" @default.
• W2174239302 modified "2023-10-17" @default.
• W2174239302 title "Are Circulating microRNAs Involved in Tumor Surveillance?" @default.
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• W2174239302 doi "https://doi.org/10.1007/978-3-0348-0955-9_13" @default.
• W2174239302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26608209" @default.
• W2174239302 hasPublicationYear "2015" @default.
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