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• W2182705280 abstract "The present study aimed to investigate the acute antihyperglycemic effects of four different solvent extracts (Petroleum ether, acetone, absolute ethanol and water) of two plants: <em>Cleome rutidosperma</em> (leaves) and <em>Senecio biafrae</em> (root) in STZ-induced diabetic mice and their <em>in vitro</em> antioxidant activities as well as their phytoconstituents. A single administration of the extracts at a dose of 500mg/kg body weight was done. All extracts as well as the standard drug, glibenclamide (at 600 μg/kg body weight) significantly lowered blood glucose level (p<0.05) of the diabetic mice by 28.784±15.46- 40.866±15.61% for <em>Cleome rutidosperma</em> and 10.652±6.36- 19.858±7.65% for <em>Senecio biafrae</em> within 6 hrs of extracts administration. The effect was more pronounced in the aqueous extracts of both plants. The median lethal dose (LD₅₀) of the extracts in rats was found to be > 5000 mg/kg body weight. The tested plant extracts displayed appreciable level of antioxidant activities by different assay methods: the ferric thiocyanate (FTC) method (26.42±1.75-56.46±2.83%), the thiobarbituric acid (TBA) method (18.43±1.67- 48.17±2.19%), reducing power method (22.76±1.87-68.45±1.07%) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method (26.23±0.94-66.12±1.41% inhibition). Quantitative phytochemical analysis of the extracts revealed the presence of Alkaloids (0.11±0.02-0.34±0.05%), Saponins (0.18±0.02-6.01±0.88%), Tannins (0.04±0.01-14.15±0.73%), Glycosides (0.002±0.001-0.113±0.040%), Phenols (0.02±0.01-0.21±0.02%), Flavonoids (0.012±0.003-0.433±0.170%) and Steroids (0.003±0.001-0.011±0.003%). Therefore, the results indicate that extracts of <em>Cleome rutidosperma</em> and <em>Senecio biafrae</em> possess significant antidiabetic and <em>in vitro</em> antioxidant activities. They are also rich in phytochemicals." @default.
• W2182705280 created "2016-06-24" @default.
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• W2182705280 date "2014-06-20" @default.
• W2182705280 modified "2023-09-25" @default.
• W2182705280 title "Comparative Antihyperglycemic Effect of Petroleum Ether, Acetone, Ethanol and Aqueous Extracts of <em>Cleome rutidosperma</em> DC and <em>Senecio biafrae</em> (Oliv. and Hiern) in Streptozotocin-induced Diabetic Mice" @default.
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• W2182705280 doi "https://doi.org/10.19026/bjpt.5.5445" @default.
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