FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2182711704> ?p ?o ?g. }

• W2182711704 endingPage "10" @default.
• W2182711704 startingPage "1605" @default.
• W2182711704 abstract "To identify tissue biomarkers that might be used to assess an individual's cancer risk and response to chemoprevention, we studied in dysplastic lesions of the larynx and the p.o. cavity, a series of biomarkers extensively used in previous chemoprevention trials, including chromosome polysomy (CP), proliferative status, p53 expression and gene mutations, and loss of heterozygosity at 9p, 3p, and 17p.Biopsies from 32 participants in a prospective chemoprevention trial using 13-cis-retinoic acid, IFN-alpha, and alpha-tocopherol for 12 months (20 with vocal cord and 12 with p.o. cavity lesions) were analyzed for p53 and Ki-67 expression by immunohistochemistry, loss of heterozygosity by PCR amplification, p53 mutations by PCR-based direct sequencing, and CP by in situ hybridization.High CP (> or =4% cells with more than three chromosome copies per nucleus) was more common in p.o. (8 of 10) than laryngeal lesions (4 of 16; P = 0.01), and so was a combination of CP > or = 4% and parabasal layer p53 labeling index > or = 0.2 (P = 0.02). Low CP was a significant predictor of complete histological response (8 of 14 cases with low versus 1 of 12 cases with high CP; P = 0.01). A trend for histological progression or cancer development was observed in cases with high CP and parabasal layer p53 labeling index.Low CP, more frequently observed in laryngeal lesions, appears to be a predictor of response to chemoprevention and could be used as a screening tool to identify suitable candidates for such approaches. Further investigation of biological parameters of response and cancer risk is warranted." @default.
• W2182711704 created "2016-06-24" @default.
• W2182711704 creator A5008790176 @default.
• W2182711704 creator A5010399375 @default.
• W2182711704 creator A5023135321 @default.
• W2182711704 creator A5041570474 @default.
• W2182711704 creator A5073876235 @default.
• W2182711704 creator A5078173230 @default.
• W2182711704 creator A5080439835 @default.
• W2182711704 creator A5085188591 @default.
• W2182711704 creator A5088436268 @default.
• W2182711704 date "2002-12-01" @default.
• W2182711704 modified "2023-10-18" @default.
• W2182711704 title "Biologic correlates of a biochemoprevention trial in advanced upper aerodigestive tract premalignant lesions." @default.
• W2182711704 cites W1514293516 @default.
• W2182711704 cites W1536591123 @default.
• W2182711704 cites W1544851750 @default.
• W2182711704 cites W1669804188 @default.
• W2182711704 cites W1899184211 @default.
• W2182711704 cites W1966165057 @default.
• W2182711704 cites W1994250758 @default.
• W2182711704 cites W2010854729 @default.
• W2182711704 cites W2086698289 @default.
• W2182711704 cites W2091867952 @default.
• W2182711704 cites W2102714041 @default.
• W2182711704 cites W2106975992 @default.
• W2182711704 cites W2107145416 @default.
• W2182711704 cites W2114576623 @default.
• W2182711704 cites W2126268703 @default.
• W2182711704 cites W2144377209 @default.
• W2182711704 cites W2164202739 @default.
• W2182711704 cites W2164584016 @default.
• W2182711704 cites W2171018079 @default.
• W2182711704 cites W2176891727 @default.
• W2182711704 cites W2183980279 @default.
• W2182711704 cites W2231620971 @default.
• W2182711704 cites W2327972628 @default.
• W2182711704 cites W2339318589 @default.
• W2182711704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12496051" @default.
• W2182711704 hasPublicationYear "2002" @default.
• W2182711704 type Work @default.
• W2182711704 sameAs 2182711704 @default.
• W2182711704 citedByCount "4" @default.
• W2182711704 crossrefType "journal-article" @default.
• W2182711704 hasAuthorship W2182711704A5008790176 @default.
• W2182711704 hasAuthorship W2182711704A5010399375 @default.
• W2182711704 hasAuthorship W2182711704A5023135321 @default.
• W2182711704 hasAuthorship W2182711704A5041570474 @default.
• W2182711704 hasAuthorship W2182711704A5073876235 @default.
• W2182711704 hasAuthorship W2182711704A5078173230 @default.
• W2182711704 hasAuthorship W2182711704A5080439835 @default.
• W2182711704 hasAuthorship W2182711704A5085188591 @default.
• W2182711704 hasAuthorship W2182711704A5088436268 @default.
• W2182711704 hasConcept C104317684 @default.
• W2182711704 hasConcept C105702510 @default.
• W2182711704 hasConcept C121608353 @default.
• W2182711704 hasConcept C126322002 @default.
• W2182711704 hasConcept C142724271 @default.
• W2182711704 hasConcept C143589142 @default.
• W2182711704 hasConcept C180754005 @default.
• W2182711704 hasConcept C204232928 @default.
• W2182711704 hasConcept C2777542201 @default.
• W2182711704 hasConcept C2780474809 @default.
• W2182711704 hasConcept C2781303241 @default.
• W2182711704 hasConcept C30481170 @default.
• W2182711704 hasConcept C54355233 @default.
• W2182711704 hasConcept C71924100 @default.
• W2182711704 hasConcept C86803240 @default.
• W2182711704 hasConceptScore W2182711704C104317684 @default.
• W2182711704 hasConceptScore W2182711704C105702510 @default.
• W2182711704 hasConceptScore W2182711704C121608353 @default.
• W2182711704 hasConceptScore W2182711704C126322002 @default.
• W2182711704 hasConceptScore W2182711704C142724271 @default.
• W2182711704 hasConceptScore W2182711704C143589142 @default.
• W2182711704 hasConceptScore W2182711704C180754005 @default.
• W2182711704 hasConceptScore W2182711704C204232928 @default.
• W2182711704 hasConceptScore W2182711704C2777542201 @default.
• W2182711704 hasConceptScore W2182711704C2780474809 @default.
• W2182711704 hasConceptScore W2182711704C2781303241 @default.
• W2182711704 hasConceptScore W2182711704C30481170 @default.
• W2182711704 hasConceptScore W2182711704C54355233 @default.
• W2182711704 hasConceptScore W2182711704C71924100 @default.
• W2182711704 hasConceptScore W2182711704C86803240 @default.
• W2182711704 hasIssue "12" @default.
• W2182711704 hasLocation W21827117041 @default.
• W2182711704 hasOpenAccess W2182711704 @default.
• W2182711704 hasPrimaryLocation W21827117041 @default.
• W2182711704 hasRelatedWork W140295764 @default.
• W2182711704 hasRelatedWork W2000739454 @default.
• W2182711704 hasRelatedWork W2030925676 @default.
• W2182711704 hasRelatedWork W2090809674 @default.
• W2182711704 hasRelatedWork W2352030788 @default.
• W2182711704 hasRelatedWork W2353044109 @default.
• W2182711704 hasRelatedWork W2388939818 @default.
• W2182711704 hasRelatedWork W2412028290 @default.
• W2182711704 hasRelatedWork W2465468598 @default.
• W2182711704 hasRelatedWork W2530457102 @default.
• W2182711704 hasVolume "11" @default.

• next