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• W2186702986 abstract "Oral squamous cell carcinoma is one of the most common cancers in the world. Novel treatment is best studied in animal models that mimic the same clinical features as human squamous cell carcinomas. For this end, 48 male Wistar rats were randomly allocated into four groups of 12 animals each. Group 1 served as control and was given the basal diet and tap water without 4-NQO. Rats from Groups 2 to 4 assigned to receive 30 ppm 4-NQO in drinking water for 12 weeks. When the feeding of 4-NQO was started the rats of groups 3 and 4, received broccoli extract at a dose of 200 and 300 mg/kg respectively, 3 times per week. At the end of experiment, the rats were euthanized and the tongue was removed. Tissue specimens collected from tongues and 5 μm thick microscopic sections were prepared through hematoxylin-eosin staining method. Histological evaluations for carcinogenesis were performed for tongues epithelial tissue. The incidences of tongue lesions were compared among the groups. There were no pathological alterations in control rats. Premalignant lesions appeared after 12 weeks of the last application of 4NQO. Administration of broccoli extract at both doses during the experiment caused a significant reduction in the frequency of tongue preneoplasms. The incidences of tongue severe dysplasia in the high dose group was significantly smaller than the low dose group (p<0.05). These findings suggest that broccoli, is effective in inhibiting the development of oral mucosa neoplasms induced by 4-NQO." @default.
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• W2186702986 date "2013-01-01" @default.
• W2186702986 modified "2023-09-26" @default.
• W2186702986 title "Histopathological study on Inhibitory effects of Brassica oleracea L. Var. Italica (Broccoli) Ethanolic extract on 4-Nitroquinoline-1- oxid -induced Pre-neoplastic changes in the Rat" @default.
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