FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2187440040> ?p ?o ?g. }

• W2187440040 abstract "Past analyses examining the relationship between genetic variation in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene and psychiatric disorders have provided mixed and largely inconclusive findings. MTHFR is involved in the one-carbon metabolic pathway which is essential for DNA biosynthesis and the epigenetic process of DNA methylation. We conducted a meta-analysis of all published case-control studies investigating associations between two common MTHFR single nucleotide polymorphisms (SNPs), MTHFR C677T (sample size 29,502) and A1298C (sample size 7934), and the major psychiatric disorders (i) schizophrenia (SZ), (ii) bipolar disorder (BPD), and (iii) unipolar depressive disorder (UDD). In order to examine possible shared genetic vulnerability, we also tested for associations between MTHFR and all of these major psychiatric disorders (SZ, BPD and UDD) combined. MTHFR C677T was significantly associated with all of the combined psychiatric disorders (SZ, BPD and UDD); random effects odds ratio (OR) = 1.26 for TT versus CC genotype carriers; confidence interval (CI) 1.09–1.46); meta-regression did not suggest moderating effects of psychiatric diagnosis, sex, ethnic group or year of publication. Although MTHFR A1298C was not significantly associated with the combination of major psychiatric disorders, nor with SZ, there was evidence for diagnostic moderation indicating a significant association with BPD (random effects OR = 2.03 for AA versus CC genotype carriers, CI: 1.07–3.86). Meta-analysis on UDD was not possible due to the small number of studies available. This study provides evidence for shared genetic vulnerability for SZ, BPD and UDD mediated by MTHFR 677TT genotype, which is in line with epigenetic involvement in the pathophysiology of these psychiatric disorders." @default.
• W2187440040 created "2016-06-24" @default.
• W2187440040 creator A5024806733 @default.
• W2187440040 creator A5030732556 @default.
• W2187440040 creator A5032232964 @default.
• W2187440040 creator A5044865126 @default.
• W2187440040 creator A5058087764 @default.
• W2187440040 creator A5058668657 @default.
• W2187440040 creator A5066037857 @default.
• W2187440040 creator A5087422318 @default.
• W2187440040 date "2011-01-01" @default.
• W2187440040 modified "2023-09-25" @default.
• W2187440040 title "Named Series: Epigenetics, Brain, Behavior, and Immunity Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: Evidence for a common genetic vulnerability?" @default.
• W2187440040 cites W171580799 @default.
• W2187440040 cites W1725224875 @default.
• W2187440040 cites W1817730472 @default.
• W2187440040 cites W1963697946 @default.
• W2187440040 cites W1971603181 @default.
• W2187440040 cites W1974945462 @default.
• W2187440040 cites W1976555550 @default.
• W2187440040 cites W1976839366 @default.
• W2187440040 cites W1980413042 @default.
• W2187440040 cites W1982342644 @default.
• W2187440040 cites W1990269273 @default.
• W2187440040 cites W1990848345 @default.
• W2187440040 cites W1993240716 @default.
• W2187440040 cites W1994335030 @default.
• W2187440040 cites W1994387786 @default.
• W2187440040 cites W1996409240 @default.
• W2187440040 cites W1999137631 @default.
• W2187440040 cites W2001125515 @default.
• W2187440040 cites W2004168520 @default.
• W2187440040 cites W2014659685 @default.
• W2187440040 cites W2015048034 @default.
• W2187440040 cites W2016093991 @default.
• W2187440040 cites W2016548228 @default.
• W2187440040 cites W2017101987 @default.
• W2187440040 cites W2019465651 @default.
• W2187440040 cites W2019813370 @default.
• W2187440040 cites W2021684461 @default.
• W2187440040 cites W2026787173 @default.
• W2187440040 cites W2026795359 @default.
• W2187440040 cites W2026963278 @default.
• W2187440040 cites W2027639190 @default.
• W2187440040 cites W2031262735 @default.
• W2187440040 cites W2031831813 @default.
• W2187440040 cites W2034443606 @default.
• W2187440040 cites W2037110628 @default.
• W2187440040 cites W2039997546 @default.
• W2187440040 cites W2044026946 @default.
• W2187440040 cites W2046692714 @default.
• W2187440040 cites W2052931289 @default.
• W2187440040 cites W2056641564 @default.
• W2187440040 cites W2064554173 @default.
• W2187440040 cites W2069070351 @default.
• W2187440040 cites W2073544062 @default.
• W2187440040 cites W2073868696 @default.
• W2187440040 cites W2076074655 @default.
• W2187440040 cites W2084980911 @default.
• W2187440040 cites W2086068891 @default.
• W2187440040 cites W2094078622 @default.
• W2187440040 cites W2096036780 @default.
• W2187440040 cites W2098529556 @default.
• W2187440040 cites W2098597355 @default.
• W2187440040 cites W2099228155 @default.
• W2187440040 cites W2099449031 @default.
• W2187440040 cites W2099615872 @default.
• W2187440040 cites W2103274613 @default.
• W2187440040 cites W2103555119 @default.
• W2187440040 cites W2105239414 @default.
• W2187440040 cites W2110267211 @default.
• W2187440040 cites W2110361971 @default.
• W2187440040 cites W2111221620 @default.
• W2187440040 cites W2112341251 @default.
• W2187440040 cites W2116713707 @default.
• W2187440040 cites W2120626403 @default.
• W2187440040 cites W2121379565 @default.
• W2187440040 cites W2125718465 @default.
• W2187440040 cites W2127205775 @default.
• W2187440040 cites W2127266406 @default.
• W2187440040 cites W2127521106 @default.
• W2187440040 cites W2133530258 @default.
• W2187440040 cites W2135149178 @default.
• W2187440040 cites W2140719667 @default.
• W2187440040 cites W2142862972 @default.
• W2187440040 cites W2149384322 @default.
• W2187440040 cites W2152482512 @default.
• W2187440040 cites W2152600990 @default.
• W2187440040 cites W2153606794 @default.
• W2187440040 cites W2155364553 @default.
• W2187440040 cites W2162876599 @default.
• W2187440040 cites W2164911583 @default.
• W2187440040 cites W2169728426 @default.
• W2187440040 cites W2288147205 @default.
• W2187440040 cites W2314289570 @default.
• W2187440040 cites W2465212687 @default.
• W2187440040 hasPublicationYear "2011" @default.
• W2187440040 type Work @default.
• W2187440040 sameAs 2187440040 @default.
• W2187440040 citedByCount "0" @default.

• next