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- W2191554571 abstract "Nucleocytoplasmic trafficking of proteins/RNAs is essential to normal cellular function. Indeed, accumulating evidence suggests that cancer cells escape anti-neoplastic mechanisms and benefit from pro-survival signals via the dysregulation of this system. The nuclear exporter chromosome region maintenance 1 (CRM1) protein is the only protein in the karyopherin-β protein family that contributes to the trafficking of numerous proteins and RNAs from the nucleus. It is considered to be an oncogenic, anti-apoptotic protein in transformed cells, since it reportedly functions as a gatekeeper for cell survival, including affecting p53 function, and ribosomal biogenesis. Furthermore, abnormally high expression of CRM1 is correlated with poor patient prognosis in various malignancies. Therapeutic targeting of CRM1 has emerged as a novel cancer treatment strategy, starting with a clinical trial with leptomycin B, the original specific inhibitor of CRM1, followed by development of several next-generation small molecules. KPT-330, a novel member of the CRM1-selective inhibitors of nuclear export (SINE) class of compounds, is currently undergoing clinical evaluation for the therapy of various malignancies. Results from these trials suggest that SINE compounds may be particularly useful against hematological malignancies, which often become refractory to standard chemotherapeutic agents." @default.
- W2191554571 created "2016-06-24" @default.
- W2191554571 creator A5039058444 @default.
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- W2191554571 creator A5049134775 @default.
- W2191554571 creator A5071506976 @default.
- W2191554571 creator A5079262854 @default.
- W2191554571 date "2015-09-01" @default.
- W2191554571 modified "2023-10-10" @default.
- W2191554571 title "Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein" @default.
- W2191554571 cites W1562998360 @default.
- W2191554571 cites W1926593386 @default.
- W2191554571 cites W1963705823 @default.
- W2191554571 cites W1964824076 @default.
- W2191554571 cites W1968110789 @default.
- W2191554571 cites W1971292362 @default.
- W2191554571 cites W1971961101 @default.
- W2191554571 cites W1976913465 @default.
- W2191554571 cites W1979070712 @default.
- W2191554571 cites W1981083415 @default.
- W2191554571 cites W1982727560 @default.
- W2191554571 cites W1985510335 @default.
- W2191554571 cites W1986955775 @default.
- W2191554571 cites W1988100051 @default.
- W2191554571 cites W1993287040 @default.
- W2191554571 cites W1993355130 @default.
- W2191554571 cites W1996313023 @default.
- W2191554571 cites W1996451804 @default.
- W2191554571 cites W1996523330 @default.
- W2191554571 cites W1999199777 @default.
- W2191554571 cites W2001956327 @default.
- W2191554571 cites W2002927399 @default.
- W2191554571 cites W2007755820 @default.
- W2191554571 cites W2008317297 @default.
- W2191554571 cites W2008511202 @default.
- W2191554571 cites W2009386327 @default.
- W2191554571 cites W2010552629 @default.
- W2191554571 cites W2012076841 @default.
- W2191554571 cites W2015158831 @default.
- W2191554571 cites W2016153572 @default.
- W2191554571 cites W2021491682 @default.
- W2191554571 cites W2021764678 @default.
- W2191554571 cites W2021789806 @default.
- W2191554571 cites W2025658684 @default.
- W2191554571 cites W2028885314 @default.
- W2191554571 cites W2033004457 @default.
- W2191554571 cites W2035296409 @default.
- W2191554571 cites W2038256325 @default.
- W2191554571 cites W2038260677 @default.
- W2191554571 cites W2039204173 @default.
- W2191554571 cites W2039212900 @default.
- W2191554571 cites W2039260633 @default.
- W2191554571 cites W2040802938 @default.
- W2191554571 cites W2045332195 @default.
- W2191554571 cites W2046497407 @default.
- W2191554571 cites W2046697661 @default.
- W2191554571 cites W2047102193 @default.
- W2191554571 cites W2047222465 @default.
- W2191554571 cites W2048647140 @default.
- W2191554571 cites W2049776490 @default.
- W2191554571 cites W2050931918 @default.
- W2191554571 cites W2051644137 @default.
- W2191554571 cites W2058710858 @default.
- W2191554571 cites W2061782012 @default.
- W2191554571 cites W2061981026 @default.
- W2191554571 cites W2064370962 @default.
- W2191554571 cites W2065677302 @default.
- W2191554571 cites W2072582894 @default.
- W2191554571 cites W2073109412 @default.
- W2191554571 cites W2077416416 @default.
- W2191554571 cites W2077682572 @default.
- W2191554571 cites W2079716952 @default.
- W2191554571 cites W2082739624 @default.
- W2191554571 cites W2087050697 @default.
- W2191554571 cites W2088909998 @default.
- W2191554571 cites W2094088075 @default.
- W2191554571 cites W2099655761 @default.
- W2191554571 cites W2103687753 @default.
- W2191554571 cites W2104537625 @default.
- W2191554571 cites W2109882555 @default.
- W2191554571 cites W2114915170 @default.
- W2191554571 cites W2115943711 @default.
- W2191554571 cites W2119483030 @default.
- W2191554571 cites W2122263758 @default.
- W2191554571 cites W2133590393 @default.
- W2191554571 cites W2134967635 @default.
- W2191554571 cites W2142496066 @default.
- W2191554571 cites W2156025284 @default.
- W2191554571 cites W2159089429 @default.
- W2191554571 cites W2168670380 @default.
- W2191554571 cites W2170515966 @default.
- W2191554571 cites W2171258458 @default.
- W2191554571 cites W2323598028 @default.
- W2191554571 cites W2367648972 @default.
- W2191554571 cites W2400794200 @default.
- W2191554571 cites W2952711392 @default.
- W2191554571 cites W324951808 @default.
- W2191554571 cites W4245546812 @default.