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- W2201118654 abstract "Pancreatic cancer is a highly lethal malignancy and a fourth leading cause of cancer-related death in the United States. Poor survival of pancreatic cancer patients is largely because of its asymptomatic progression to advanced stage against which no effective therapy is currently available. Over the years, we have developed significant knowledge of molecular progression of pancreatic cancer and identified several genetic and epigenetic aberrations to be involved in its etiology and aggressive behavior. In that regard, recent lines of evidence have suggested important roles of microRNAs (miRNAs/miRs) in pancreatic cancer pathogenesis. microRNAs belonging to a family of small, noncoding RNAs are able to control diverse biological processes due to their ability to regulate gene expression at the posttranscriptional level. Accordingly, dysregulation of miRNAs can lead to several disease conditions, including cancer. There is a long list of microRNAs that exhibit aberrant expression in pancreatic cancer and serve as key microplayers in its initiation, progression, metastasis, and chemoresistance. These findings have suggested that microRNAs could be exploited as novel biomarkers for diagnostic and prognostic assessments of pancreatic cancer and as targets for therapy. This book chapter describes clinical problems associated with pancreatic cancer, roles that microRNAs play in various aspects of pancreatic cancer pathogenesis, and envision opportunities for potential use of microRNAs in pancreatic cancer management." @default.
- W2201118654 created "2016-06-24" @default.
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- W2201118654 date "2015-01-01" @default.
- W2201118654 modified "2023-09-30" @default.
- W2201118654 title "Insights into the Role of microRNAs in Pancreatic Cancer Pathogenesis: Potential for Diagnosis, Prognosis, and Therapy" @default.
- W2201118654 cites W1510389712 @default.
- W2201118654 cites W1530269273 @default.
- W2201118654 cites W1594221952 @default.
- W2201118654 cites W162922609 @default.
- W2201118654 cites W1712437357 @default.
- W2201118654 cites W1964813626 @default.
- W2201118654 cites W1968741529 @default.
- W2201118654 cites W1968812902 @default.
- W2201118654 cites W1969192247 @default.
- W2201118654 cites W1975412433 @default.
- W2201118654 cites W1976057417 @default.
- W2201118654 cites W1976549493 @default.
- W2201118654 cites W1976971569 @default.
- W2201118654 cites W1983720493 @default.
- W2201118654 cites W1985988050 @default.
- W2201118654 cites W1986110037 @default.
- W2201118654 cites W1989199090 @default.
- W2201118654 cites W1995399248 @default.
- W2201118654 cites W2004671522 @default.
- W2201118654 cites W2006478411 @default.
- W2201118654 cites W2008099498 @default.
- W2201118654 cites W2012940015 @default.
- W2201118654 cites W2014200421 @default.
- W2201118654 cites W2014442719 @default.
- W2201118654 cites W2014783179 @default.
- W2201118654 cites W2015447772 @default.
- W2201118654 cites W2015751470 @default.
- W2201118654 cites W2020080445 @default.
- W2201118654 cites W2021251343 @default.
- W2201118654 cites W2022896276 @default.
- W2201118654 cites W2023987874 @default.
- W2201118654 cites W2026468262 @default.
- W2201118654 cites W2029614054 @default.
- W2201118654 cites W2031731215 @default.
- W2201118654 cites W2032076922 @default.
- W2201118654 cites W2035987476 @default.
- W2201118654 cites W2037044064 @default.
- W2201118654 cites W2038167014 @default.
- W2201118654 cites W2041095872 @default.
- W2201118654 cites W2043510501 @default.
- W2201118654 cites W2045021672 @default.
- W2201118654 cites W2045857417 @default.
- W2201118654 cites W2051227958 @default.
- W2201118654 cites W2051244930 @default.
- W2201118654 cites W2052064592 @default.
- W2201118654 cites W2052783034 @default.
- W2201118654 cites W2054665580 @default.
- W2201118654 cites W2056424427 @default.
- W2201118654 cites W2056494524 @default.
- W2201118654 cites W2059304543 @default.
- W2201118654 cites W2061174980 @default.
- W2201118654 cites W2066868410 @default.
- W2201118654 cites W2067708466 @default.
- W2201118654 cites W2068588364 @default.
- W2201118654 cites W2073816554 @default.
- W2201118654 cites W2076060004 @default.
- W2201118654 cites W2079251691 @default.
- W2201118654 cites W2085636773 @default.
- W2201118654 cites W2088110734 @default.
- W2201118654 cites W2088832018 @default.
- W2201118654 cites W2090268947 @default.
- W2201118654 cites W2098267886 @default.
- W2201118654 cites W2098653030 @default.
- W2201118654 cites W2106278870 @default.
- W2201118654 cites W2107441200 @default.
- W2201118654 cites W2111471857 @default.
- W2201118654 cites W2112087504 @default.
- W2201118654 cites W2112417639 @default.
- W2201118654 cites W2113311589 @default.
- W2201118654 cites W2116865990 @default.
- W2201118654 cites W2119492915 @default.
- W2201118654 cites W2121091450 @default.
- W2201118654 cites W2123746627 @default.
- W2201118654 cites W2123962115 @default.
- W2201118654 cites W2124488916 @default.
- W2201118654 cites W2126879824 @default.
- W2201118654 cites W2129615821 @default.
- W2201118654 cites W2131104906 @default.
- W2201118654 cites W2135613885 @default.
- W2201118654 cites W2138799354 @default.
- W2201118654 cites W2139471389 @default.
- W2201118654 cites W2142801414 @default.
- W2201118654 cites W2145403987 @default.
- W2201118654 cites W2146331115 @default.
- W2201118654 cites W2152036735 @default.
- W2201118654 cites W2152184695 @default.
- W2201118654 cites W2153661308 @default.
- W2201118654 cites W2157615672 @default.