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• W2218218446 endingPage "1153" @default.
• W2218218446 startingPage "1145" @default.
• W2218218446 abstract "Vitamin D deficiency may cause muscular impairment even before adverse effects on bone occur. Vitamin D is essential for bone growth and preservation, and higher 25(OH)D levels are associated with higher bone density in younger and older adults. Vitamin D deficiency may cause muscular impairment even before adverse effects on bone occur. Mechanistically, fractures at later age are closely linked to muscle weakness and falling. Several recent meta-analyses of randomized, controlled trials have addressed the benefit of vitamin D on fracture risk reduction with conflicting findings. Different findings and conclusions may be explained by differences in the selection of trials included in the meta-analysis, with respect to design. Also, in double-blind RCTs, vitamin D supplementation increase bone density and reduce bone loss. Based on evidence from RCTs, oral vitamin D supplementation reduces both falls and non-vertebral fractures, including those at the hip. However, this benefit is dose-dependent and a dose of 700–1000 IU vitamin D per day is required to assure both fall and fracture prevention. For optimal fall and fracture reduction a serum 25(OH)D concentration of at least 75 nmol/l is required. This threshold may be reached with 800 to 1000 IU vitamin D in 50% of adults, whereas higher doses of vitamin D would be required to shift all adults to this threshold." @default.
• W2218218446 created "2016-06-24" @default.
• W2218218446 creator A5024962441 @default.
• W2218218446 creator A5090709918 @default.
• W2218218446 date "2011-01-01" @default.
• W2218218446 modified "2023-09-23" @default.
• W2218218446 title "Relevance of Vitamin D Deficiency in Adult Fracture and Fall Prevention" @default.
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• W2218218446 doi "https://doi.org/10.1016/b978-0-12-381978-9.10062-9" @default.
• W2218218446 hasPublicationYear "2011" @default.
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