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• W2221167212 endingPage "1387" @default.
• W2221167212 startingPage "1373" @default.
• W2221167212 abstract "The major site of lymphoid cells in the healthy liver is the portal area, which has a predominance of CD3 + T lymphocytes. Primary biliary cirrhosis (PBC) is a chronic cholestatic (impaired excretion of bile acids) disease. The fundamental pathologic process is the—T cell–mediated inflammation and destruction of interlobular and septal bile ducts, a process referred to as nonsuppurative destructive cholangitis. Evidence suggests that PBC is a generalized mucosal disease, which provides a basis for considering whether its etiology involves enterohepatic circulation of toxins and/or infectious agents. A distinctive feature of PBC is a marked polyclonal hyper-gammaglobulinemia. Serum IgM, IgG, and IgA levels all are elevated, but the most striking elevation is in the IgM level, which may be greater than five times normal. The concept of molecular mimicry of autoepitopes by peptides of microorganisms is particularly important for PBC because of the propensity of several viruses to specifically target the liver." @default.
• W2221167212 created "2016-06-24" @default.
• W2221167212 creator A5083139340 @default.
• W2221167212 date "2005-01-01" @default.
• W2221167212 modified "2023-10-17" @default.
• W2221167212 title "Liver and Biliary Tract" @default.
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