FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2231866504> ?p ?o ?g. }

• W2231866504 endingPage "4156" @default.
• W2231866504 startingPage "4151" @default.
• W2231866504 abstract "Primary human bone marrow megakaryocytes were studied for their ability to express and release cytokines potentially relevant to their proliferation and/or differentiation. The purity of the bone marrow megakaryocytes was assessed by morphologic and immunocytochemical criteria. Unstimulated marrow megakaryocytes constitutively expressed genes for interleukin-1 beta (IL-1 beta), IL-6, granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor-alpha (TNF-alpha), by the polymerase chain reaction (PCR) and Northern blot analysis. At the protein level, megakaryocytes secreted significant amounts of IL-1 beta (53.6 +/- 3.6 pg/mL), IL-6 (57.6 +/- 15.6 pg/mL), and GM-CSF (24 +/- 4 pg/mL) but not TNF-alpha. Exposure of human marrow megakaryocytes to IL-1 beta increased the levels of IL-6 (87.3 +/- 2.3 pg/mL) detected in the culture supernatants. Transforming growth factor- beta was also able to stimulate IL-6, IL-1 beta, and GM-CSF secretion, but was less potent than stimulation with phorbol-12-myristate-13- acetate (PMA). The secreted cytokines acted additively to maintain and increase the number of colony-forming unit-megakaryocytes colonies (approximately 35%). These studies demonstrate the production of multiple cytokines by isolated human bone marrow megakaryocytes constitutively or stimulated in vitro. The capacity of human megakaryocytes to synthesize several cytokines known to modulate hematopoietic cells supports the concept that there may be an autocrine mechanism operative in the regulation of megakaryocytopoiesis." @default.
• W2231866504 created "2016-06-24" @default.
• W2231866504 creator A5014319544 @default.
• W2231866504 creator A5037532465 @default.
• W2231866504 creator A5046788511 @default.
• W2231866504 creator A5049975962 @default.
• W2231866504 creator A5071368144 @default.
• W2231866504 creator A5073353369 @default.
• W2231866504 creator A5087194419 @default.
• W2231866504 date "1994-12-15" @default.
• W2231866504 modified "2023-09-30" @default.
• W2231866504 title "Cytokine production by primary bone marrow megakaryocytes" @default.
• W2231866504 cites W1488601882 @default.
• W2231866504 cites W1493122314 @default.
• W2231866504 cites W1742452979 @default.
• W2231866504 cites W1991230880 @default.
• W2231866504 cites W2022977480 @default.
• W2231866504 cites W2025466093 @default.
• W2231866504 cites W2033093905 @default.
• W2231866504 cites W2110673870 @default.
• W2231866504 cites W2140922568 @default.
• W2231866504 cites W2149604229 @default.
• W2231866504 cites W2168146165 @default.
• W2231866504 cites W2253467765 @default.
• W2231866504 cites W2253716135 @default.
• W2231866504 cites W2269012571 @default.
• W2231866504 cites W2289970674 @default.
• W2231866504 cites W2339498071 @default.
• W2231866504 cites W2374798852 @default.
• W2231866504 cites W2415098890 @default.
• W2231866504 cites W2422717905 @default.
• W2231866504 cites W2428930535 @default.
• W2231866504 cites W244034654 @default.
• W2231866504 cites W336773932 @default.
• W2231866504 doi "https://doi.org/10.1182/blood.v84.12.4151.bloodjournal84124151" @default.
• W2231866504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7527669" @default.
• W2231866504 hasPublicationYear "1994" @default.
• W2231866504 type Work @default.
• W2231866504 sameAs 2231866504 @default.
• W2231866504 citedByCount "84" @default.
• W2231866504 countsByYear W22318665042012 @default.
• W2231866504 countsByYear W22318665042013 @default.
• W2231866504 countsByYear W22318665042014 @default.
• W2231866504 countsByYear W22318665042015 @default.
• W2231866504 countsByYear W22318665042016 @default.
• W2231866504 countsByYear W22318665042017 @default.
• W2231866504 countsByYear W22318665042018 @default.
• W2231866504 countsByYear W22318665042019 @default.
• W2231866504 countsByYear W22318665042021 @default.
• W2231866504 countsByYear W22318665042022 @default.
• W2231866504 countsByYear W22318665042023 @default.
• W2231866504 crossrefType "journal-article" @default.
• W2231866504 hasAuthorship W2231866504A5014319544 @default.
• W2231866504 hasAuthorship W2231866504A5037532465 @default.
• W2231866504 hasAuthorship W2231866504A5046788511 @default.
• W2231866504 hasAuthorship W2231866504A5049975962 @default.
• W2231866504 hasAuthorship W2231866504A5071368144 @default.
• W2231866504 hasAuthorship W2231866504A5073353369 @default.
• W2231866504 hasAuthorship W2231866504A5087194419 @default.
• W2231866504 hasBestOaLocation W22318665041 @default.
• W2231866504 hasConcept C109159458 @default.
• W2231866504 hasConcept C126322002 @default.
• W2231866504 hasConcept C128240485 @default.
• W2231866504 hasConcept C134018914 @default.
• W2231866504 hasConcept C153911025 @default.
• W2231866504 hasConcept C170493617 @default.
• W2231866504 hasConcept C17991360 @default.
• W2231866504 hasConcept C203014093 @default.
• W2231866504 hasConcept C2775960820 @default.
• W2231866504 hasConcept C2777918643 @default.
• W2231866504 hasConcept C2778690821 @default.
• W2231866504 hasConcept C2779705218 @default.
• W2231866504 hasConcept C2780007613 @default.
• W2231866504 hasConcept C28328180 @default.
• W2231866504 hasConcept C54355233 @default.
• W2231866504 hasConcept C55493867 @default.
• W2231866504 hasConcept C71924100 @default.
• W2231866504 hasConcept C81885089 @default.
• W2231866504 hasConcept C86803240 @default.
• W2231866504 hasConcept C95444343 @default.
• W2231866504 hasConceptScore W2231866504C109159458 @default.
• W2231866504 hasConceptScore W2231866504C126322002 @default.
• W2231866504 hasConceptScore W2231866504C128240485 @default.
• W2231866504 hasConceptScore W2231866504C134018914 @default.
• W2231866504 hasConceptScore W2231866504C153911025 @default.
• W2231866504 hasConceptScore W2231866504C170493617 @default.
• W2231866504 hasConceptScore W2231866504C17991360 @default.
• W2231866504 hasConceptScore W2231866504C203014093 @default.
• W2231866504 hasConceptScore W2231866504C2775960820 @default.
• W2231866504 hasConceptScore W2231866504C2777918643 @default.
• W2231866504 hasConceptScore W2231866504C2778690821 @default.
• W2231866504 hasConceptScore W2231866504C2779705218 @default.
• W2231866504 hasConceptScore W2231866504C2780007613 @default.
• W2231866504 hasConceptScore W2231866504C28328180 @default.
• W2231866504 hasConceptScore W2231866504C54355233 @default.
• W2231866504 hasConceptScore W2231866504C55493867 @default.
• W2231866504 hasConceptScore W2231866504C71924100 @default.
• W2231866504 hasConceptScore W2231866504C81885089 @default.

• next