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- W2289724404 endingPage "20150122" @default.
- W2289724404 startingPage "20150122" @default.
- W2289724404 abstract "In recent years, the bidirectional communication between the gut microbiome and the brain has emerged as a factor that influences immunity, metabolism, neurodevelopment and behaviour. Cross-talk between the gut and brain begins early in life immediately following the transition from a sterile in utero environment to one that is exposed to a changing and complex microbial milieu over a lifetime. Once established, communication between the gut and brain integrates information from the autonomic and enteric nervous systems, neuroendocrine and neuroimmune signals, and peripheral immune and metabolic signals. Importantly, the composition and functional potential of the gut microbiome undergoes many transitions that parallel dynamic periods of brain development and maturation for which distinct sex differences have been identified. Here, we discuss the sexually dimorphic development, maturation and maintenance of the gut microbiome–brain axis, and the sex differences therein important in disease risk and resilience throughout the lifespan." @default.
- W2289724404 created "2016-06-24" @default.
- W2289724404 creator A5051876711 @default.
- W2289724404 creator A5057744124 @default.
- W2289724404 creator A5066980572 @default.
- W2289724404 date "2016-02-19" @default.
- W2289724404 modified "2023-10-15" @default.
- W2289724404 title "Sex differences in the gut microbiome–brain axis across the lifespan" @default.
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