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- W2292100077 endingPage "711" @default.
- W2292100077 startingPage "696" @default.
- W2292100077 abstract "The circadian clock is a biological timekeeping system that provides organisms with the ability to adapt to day-night cycles. Timing of the expression of four members of the Arabidopsis thaliana PSEUDO-RESPONSE REGULATOR(PRR) family is crucial for proper clock function, and transcriptional control of PRRs remains incompletely defined. Here, we demonstrate that direct regulation of PRR5 by CIRCADIAN CLOCK-ASSOCIATED1 (CCA1) determines the repression state of PRR5 in the morning. Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) analyses indicated that CCA1 associates with three separate regions upstream of PRR5 CCA1 and its homolog LATE ELONGATED HYPOCOTYL (LHY) suppressed PRR5 promoter activity in a transient assay. The regions bound by CCA1 in the PRR5 promoter gave rhythmic patterns with troughs in the morning, when CCA1 and LHY are at high levels. Furthermore,ChIP-seq revealed that CCA1 associates with at least 449 loci with 863 adjacent genes. Importantly, this gene set contains genes that are repressed but upregulated incca1 lhy double mutants in the morning. This study shows that direct binding by CCA1 in the morning provides strong repression of PRR5, and repression by CCA1 also temporally regulates an evening-expressed gene set that includes PRR5." @default.
- W2292100077 created "2016-06-24" @default.
- W2292100077 creator A5005278924 @default.
- W2292100077 creator A5008724205 @default.
- W2292100077 creator A5008893064 @default.
- W2292100077 creator A5012187265 @default.
- W2292100077 creator A5012949298 @default.
- W2292100077 creator A5013995574 @default.
- W2292100077 creator A5048592550 @default.
- W2292100077 date "2016-03-01" @default.
- W2292100077 modified "2023-10-17" @default.
- W2292100077 title "Direct Repression of Evening Genes by CIRCADIAN CLOCK-ASSOCIATED1 in the Arabidopsis Circadian Clock" @default.
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